Histopathology data for Mtor

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #1 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed Moderate hepatic steatosis
HET M #4 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #3 Thyroid normal [MPATH:458] 0 0
HET F #1 Eye with optic nerve normal [MPATH:458] 0 0
HET F #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #4 Testes normal [MPATH:458] 0 0
HET M #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET M #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #1 Thyroid normal [MPATH:458] 0 0
HET F #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #1 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 lymphoid hyperplasia MPATH:147 distributed subacute Lymphoid hyperplasia.
HET F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #2 Thymus [MA:0000142] developmental and structural abnormality [MPATH:55] 1 0 cyst MPATH:62 localized Epithelial cyst
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #2 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 lymphoid hyperplasia MPATH:147 distributed subacute Lymphoid hyperplasia.
HET M #3 Prostate normal [MPATH:458] 0 0
HET F #2 Thyroid normal [MPATH:458] 0 0
HET M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #3 Testes normal [MPATH:458] 0 0
HET M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #3 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 lymphoid hyperplasia MPATH:147 subacute distributed Lymphoid hyperplasia.
HET F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #1 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #1 Thymus [MA:0000142] developmental and structural abnormality [MPATH:55] 1 0 cyst MPATH:62 localized Epithelial cyst
HET M #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 lymphoid hyperplasia MPATH:147 subacute distributed Lymphoid hyperplasia.
HET M #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #4 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed Moderate hepatic steatosis
HET F #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #4 Thyroid normal [MPATH:458] 0 0
HET M #3 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #2 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET M #4 Prostate normal [MPATH:458] 0 0
HET M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #3 Thymus [MA:0000142] developmental and structural abnormality [MPATH:55] 1 0 cyst MPATH:62 localized Epithelial cyst
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #3 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #3 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed Moderate hepatic steatosis
HET M #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #4 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #4 Eye with optic nerve normal [MPATH:458] 0 0
HET M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #2 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed Moderate hepatic steatosis
HET F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #4 Thymus [MA:0000142] normal [MPATH:458] 0 0

Associated histopathology images

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