Histopathology data for Map3k1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET F #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #1 Eye with optic nerve normal [MPATH:458] 0 0
HET F #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET F #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #3 Eye with optic nerve normal [MPATH:458] developmental and structural abnormality [MPATH:55] multi-localised
HET F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HET M #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Prostate normal [MPATH:458] 0 0
HET F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #3
HET M #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #4 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #3 Prostate normal [MPATH:458] 0 0
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #4 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 distributed Lymphoid hyperplasia
HET F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET M #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #3 Testes normal [MPATH:458] 0 0
HET F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #1 Thyroid normal [MPATH:458] 0 0
HET M #1 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #3 Skin [MA:0000151] inflammation [MPATH:212] 1 0 multi-localised Epidermitis, multifocal
HET M #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #2 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Testes normal [MPATH:458] 0 0
HET M #3 Thyroid normal [MPATH:458] 0 0
HET M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #4 Eye with optic nerve normal [MPATH:458] 0 0
HET M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #3 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 Dilation of the brain ventricles
HET M #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #4 Thyroid normal [MPATH:458] 0 0
HET F #2 Thyroid normal [MPATH:458] 0 0
HET F #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HET M #3 Eye with optic nerve 0 0
HET M #3 Thymus [MA:0000142] developmental and structural abnormality [MPATH:55] 1 0 cyst MPATH:62 multi-localised Epithelial cyst
HET M #3 Eye with optic nerve 1 0 Retinal dysplasia
HET F #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] 0 0
HET M #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0

Associated histopathology images

Map3k1
heterozygote
Map3k1tm1a(KOMP)Wtsi
experimental
Map3k1
heterozygote
Map3k1tm1a(KOMP)Wtsi
experimental
Map3k1
heterozygote
Map3k1tm1a(KOMP)Wtsi
experimental
Map3k1
heterozygote
Eye with optic nerve MA:0000276
MA:0000261 eye
Map3k1tm1a(KOMP)Wtsi
experimental

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