Histopathology data for Lamtor5

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #3 Thyroid normal [MPATH:458] 0 0
HET F #2 Thyroid normal [MPATH:458] 0 0
HET F #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Ovary [MA:0000384] Not applicable
HET M #1 Eye with optic nerve normal [MPATH:458] 0 0
HET M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3
HET F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #4 Testes Not applicable
HET F #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Uterus [MA:0000389] Not applicable
HET M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #4 Seminal vesicle [MA:0000410] Not applicable
HET F #2 Epididymis [MA:0000397] Not applicable
HET F #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #4
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #2 Testes Not applicable
HET M #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] 0 0
HET F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #3 Eye with optic nerve normal [MPATH:458] 0 0
HET M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #2 Prostate Not applicable
HET M #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #3 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Testes normal [MPATH:458] 0 0
HET M #3 Mammary gland [MA:0000145] Not applicable
HET F #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #4 Epididymis [MA:0000397] Not applicable
HET F #2
HET M #1 Prostate normal [MPATH:458] 0 0
HET M #1 Thyroid normal [MPATH:458] 0 0
HET F #4 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #4 Eye with optic nerve normal [MPATH:458] 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #1 Mammary gland [MA:0000145] Not applicable
HET F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #2 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #4 Kidney [MA:0000368] inflammation [MPATH:212] 1 0 chronic multi-localised Pericalyceal and focal interstitial nephritis.
HET F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #1 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Spleen [MA:0000141] hyperplasia [MPATH:134] 2 0 multi-localised chronic Lymphocyte hyperplasia. Spleen.
HET F #4 Prostate Not applicable
HET M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #4 Thyroid normal [MPATH:458] 0 0
HET M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #4 Liver [MA:0000358] inflammation [MPATH:212] 1 0 multi-localised chronic Multifocal mononuclear inflammatory cell aggregates and focal necrosis.
HET F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HET M #3 Uterus [MA:0000389] Not applicable
HET M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #2 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #3 Ovary [MA:0000384] Not applicable
HET M #1 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #3 Testes normal [MPATH:458] 0 0
HET M #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #2 Seminal vesicle [MA:0000410] Not applicable
HET M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #3 Prostate normal [MPATH:458] 0 0
HET F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HET M #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #3 Lymph node [MA:0000139] neoplasm [MPATH:218] 3 0 lymphoid neoplasms MPATH:513 chronic distributed Lymphoma, cervical lymph node.
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #3 Spleen [MA:0000141] hyperplasia [MPATH:134] 2 0 multi-localised chronic Lymphocyte hyperplasia. Spleen.
HET F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0

Associated histopathology images

Lamtor5
heterozygote
Lymph node MA:0000736
MA:0000139 lymph node
Lamtor5tm1b(EUCOMM)Hmgu
experimental
Lamtor5
heterozygote
Spleen MA:0000141
MA:0000141 spleen
Lamtor5tm1b(EUCOMM)Hmgu
experimental
Lamtor5
heterozygote
Liver MA:0000358
MA:0000358 liver
Lamtor5tm1b(EUCOMM)Hmgu
experimental
Lamtor5
heterozygote
Kidney MA:0000368
MA:0000368 kidney
Lamtor5tm1b(EUCOMM)Hmgu
experimental
Lamtor5
heterozygote
Spleen MA:0000141
MA:0000141 spleen
Lamtor5tm1b(EUCOMM)Hmgu
experimental
Lamtor5
heterozygote
Kidney MA:0000368
MA:0000368 kidney
Lamtor5tm1b(EUCOMM)Hmgu
experimental

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter