Histopathology data for Ifi44

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #3 Skeletal muscle [MA:0003148] 0 0
HOM F #4 Salivary gland [MA:0000346] normal [MPATH:458]
HOM F #4 Kidney [MA:0000368] 0 0
HOM F #4 Sternum [MA:0001331] 0 0
HOM F #2 Heart [MA:0000072] normal [MPATH:458]
HOM F #4 Spleen [MA:0000141] 0 0
HOM M #3 Eye with optic nerve developmental and structural abnormality [MPATH:55] multi-localised
HOM F #4 Ovary [MA:0000384] 0 0
HOM F #2 Salivary gland [MA:0000346] 0 0
HOM F #2 Trachea [MA:0000441] 0 0
HOM M #3 Bone marrow [MA:0000134] 0 0
HOM F #2 Lymph node [MA:0000139] 0 0
HOM F #2 Nasal cavity [MA:0000284] 0 0
HOM F #2 Gall bladder [MA:0000356] 0 0
HOM M #3 Skin [MA:0000151] 0 0
HOM M #1 Adrenal gland [MA:0000116] 0 0
HOM M #3 Salivary gland [MA:0000346] normal [MPATH:458]
HOM M #1 Large intestine [MA:0000333] 0 0
HOM F #4 Lung [MA:0000415] 0 0
HOM F #4 Mammary gland [MA:0000145] normal [MPATH:458]
HOM M #3 Thyroid 0 0
HOM F #4 Tongue [MA:0000347] 0 0
HOM F #2 Spleen [MA:0000141] normal [MPATH:458]
HOM M #3 Ear [MA:0000236] 0 0
HOM F #4 Stomach [MA:0000353] 0 0
HOM M #3 Large intestine [MA:0000333] 0 0
HOM F #4 Brain [MA:0000168] 0 0
HOM M #3 Liver [MA:0000358] normal [MPATH:458]
HOM F #2 Gall bladder [MA:0000356] normal [MPATH:458]
HOM M #1 Esophagus [MA:0000352] normal [MPATH:458]
HOM M #1 Stomach [MA:0000353] normal [MPATH:458]
HOM M #1 Sciatic nerve [MA:0001172] normal [MPATH:458]
HOM F #2 Tongue [MA:0000347] 0 0
HOM M #3 Urinary bladder [MA:0000380] 0 0
HOM M #1 Lung [MA:0000415] inflammation [MPATH:212] focally extensive
HOM M #3 Seminal vesicle [MA:0000410] 0 0
HOM M #1 Ear [MA:0000236] 0 0
HOM F #4 Esophagus [MA:0000352] 0 0
HOM F #2 Lymph node [MA:0000139] normal [MPATH:458]
HOM F #2 Brain [MA:0000168] 0 0
HOM F #2 Lung [MA:0000415] normal [MPATH:458]
HOM M #3 Adrenal gland [MA:0000116] 0 0
HOM F #4 Spinal cord [MA:0000216] normal [MPATH:458]
HOM M #1 Small intestine [MA:0000337] 0 0
HOM F #2 Adrenal gland [MA:0000116] normal [MPATH:458]
HOM F #4 Sciatic nerve [MA:0001172] 0 0
HOM F #2 Small intestine [MA:0000337] 0 0
HOM M #1 Skeletal muscle [MA:0003148] normal [MPATH:458]
HOM M #1 Sternum [MA:0001331] normal [MPATH:458]
HOM M #3 Ear [MA:0000236] normal [MPATH:458]
HOM F #4 Urinary bladder [MA:0000380] normal [MPATH:458]
HOM M #1 Testes normal [MPATH:458]
HOM M #3 Kidney [MA:0000368] normal [MPATH:458]
HOM F #4 Heart [MA:0000072] 0 0
HOM F #4 Tooth [MA:0000348] normal [MPATH:458]
HOM F #2 Esophagus [MA:0000352] 0 0
HOM F #2 Sciatic nerve [MA:0001172] 0 0
HOM M #1 Pancreas [MA:0000120] normal [MPATH:458]
HOM M #1 Bone marrow [MA:0000134] 0 0
HOM M #1 Seminal vesicle [MA:0000410] 0 0
HOM M #1 Urinary bladder [MA:0000380] 0 0
HOM M #1 Nasal cavity [MA:0000284] normal [MPATH:458]
HOM M #3 Tooth [MA:0000348] normal [MPATH:458]
HOM M #1 Tongue [MA:0000347] normal [MPATH:458]
HOM M #1 Trachea [MA:0000441] normal [MPATH:458]
HOM F #4 Tooth [MA:0000348] 0 0
HOM M #3 Thymus [MA:0000142] 0 0
HOM F #2 Ovary [MA:0000384] 0 0
HOM M #1 Lymph node [MA:0000139] 0 0
HOM M #1 Seminal vesicle [MA:0000410] normal [MPATH:458]
HOM M #1 Trachea [MA:0000441] 0 0
HOM M #3 Spinal cord [MA:0000216] normal [MPATH:458]
HOM M #3 Seminal vesicle [MA:0000410] normal [MPATH:458]
HOM M #1 Nasal cavity [MA:0000284] 0 0
HOM F #2 Kidney [MA:0000368] normal [MPATH:458]
HOM F #2 Skin [MA:0000151] normal [MPATH:458]
HOM F #2 Spleen [MA:0000141] 0 0
HOM F #4 Ear [MA:0000236] normal [MPATH:458]
HOM M #3 Spleen [MA:0000141] normal [MPATH:458]
HOM F #4 Femur [MA:0001359] normal [MPATH:458]
HOM F #2 Large intestine [MA:0000333] 0 0
HOM F #4 Thyroid normal [MPATH:458]
HOM F #2 Thymus [MA:0000142] normal [MPATH:458]
HOM F #2 Liver [MA:0000358] normal [MPATH:458]
HOM M #1 Prostate normal [MPATH:458]
HOM F #4 Lymph node [MA:0000139] Not applicable 0 Lymphoma
HOM F #4 Spleen [MA:0000141] normal [MPATH:458]
HOM F #4 Nasal cavity [MA:0000284] 0 0
HOM M #1 Epididymis [MA:0000397] normal [MPATH:458]
HOM F #4 Trachea [MA:0000441] 0 0
HOM F #4 Small intestine [MA:0000337] normal [MPATH:458]
HOM M #3 Femur [MA:0001359] normal [MPATH:458]
HOM F #2 Uterus [MA:0000389] normal [MPATH:458]
HOM M #1 Lymph node [MA:0000139] normal [MPATH:458]
HOM M #1 Skin [MA:0000151] 0 0
HOM F #4 Heart [MA:0000072] normal [MPATH:458]
HOM F #2 Skeletal muscle [MA:0003148] normal [MPATH:458]
HOM F #4 Skeletal muscle [MA:0003148] 0 0
HOM F #4 Skin [MA:0000151] 0 0
HOM F #4 Thymus [MA:0000142] 0 0
HOM F #2 Stomach [MA:0000353] 0 0
HOM F #2 Skin [MA:0000151] 0 0
HOM M #1 Thymus [MA:0000142] normal [MPATH:458]
HOM M #1 Skeletal muscle [MA:0003148] 0 0
HOM F #2 Skeletal muscle [MA:0003148] 0 0
HOM M #3 Heart [MA:0000072] normal [MPATH:458]
HOM M #1 Stomach [MA:0000353] 0 0
HOM F #2 Lung [MA:0000415] 0 0
HOM M #1 Lung [MA:0000415] 2 0 Acidophilic macrophage pneumonia
HOM F #4 Ovary [MA:0000384] normal [MPATH:458]
HOM F #2 Stomach [MA:0000353] normal [MPATH:458]
HOM M #3 Trachea [MA:0000441] 0 0
HOM M #1 Kidney [MA:0000368] normal [MPATH:458]
HOM M #3 Stomach [MA:0000353] 0 0
HOM M #3 Lung [MA:0000415] normal [MPATH:458]
HOM M #1 Tooth [MA:0000348] 0 0
HOM F #2 Tooth [MA:0000348] 0 0
HOM M #1 Skin [MA:0000151] normal [MPATH:458]
HOM M #1 Thymus [MA:0000142] 0 0
HOM F #2 Thymus [MA:0000142] 0 0
HOM M #3 Tooth [MA:0000348] 0 0
HOM M #1 Testes 0 0
HOM F #4 Stomach [MA:0000353] normal [MPATH:458]
HOM F #2 Thyroid 0 0
HOM F #4 Lung [MA:0000415] normal [MPATH:458]
HOM F #4 Brain [MA:0000168] normal [MPATH:458]
HOM F #2 Trachea [MA:0000441] normal [MPATH:458]
HOM M #3 Tongue [MA:0000347] normal [MPATH:458]
HOM M #3 Esophagus [MA:0000352] 0 0
HOM M #1 Epididymis [MA:0000397] 0 0
HOM M #3 Nasal cavity [MA:0000284] normal [MPATH:458]
HOM F #4 Skeletal muscle [MA:0003148] normal [MPATH:458]
HOM M #3 Brain [MA:0000168] 0 0
HOM M #3 Heart [MA:0000072] 0 0
HOM F #2 Spinal cord [MA:0000216] normal [MPATH:458]
HOM F #4 Uterus [MA:0000389] normal [MPATH:458]
HOM F #4 Urinary bladder [MA:0000380] 0 0
HOM M #3 Tongue [MA:0000347] 0 0
HOM M #1 Liver [MA:0000358] normal [MPATH:458]
HOM M #3 Skin [MA:0000151] normal [MPATH:458]
HOM M #3 Nasal cavity [MA:0000284] 0 0
HOM M #3 Lung [MA:0000415] 0 0
HOM M #3 Sciatic nerve [MA:0001172] 0 0
HOM M #3 Lymph node [MA:0000139] 0 0
HOM F #2 Urinary bladder [MA:0000380] normal [MPATH:458]
HOM F #2 Ovary [MA:0000384] normal [MPATH:458]
HOM F #4 Tongue [MA:0000347] normal [MPATH:458]
HOM F #2 Mammary gland [MA:0000145] normal [MPATH:458]
HOM M #1 Spleen [MA:0000141] 0 0
HOM M #3 Gall bladder [MA:0000356] 0 0
HOM M #3 Stomach [MA:0000353] normal [MPATH:458]
HOM M #1 Tooth [MA:0000348] normal [MPATH:458]
HOM F #2 Eye with optic nerve 1 0 Persistant hyaloid artery (posterior remnant)
HOM F #4 Nasal cavity [MA:0000284] normal [MPATH:458]
HOM M #1 Kidney [MA:0000368] 0 0
HOM M #3 Spleen [MA:0000141] 0 0
HOM F #4 Skin [MA:0000151] normal [MPATH:458]
HOM F #4 Adrenal gland [MA:0000116] 0 0
HOM F #2 Pancreas [MA:0000120] normal [MPATH:458]
HOM M #1 Eye with optic nerve developmental and structural abnormality [MPATH:55] multi-localised
HOM M #3 Skeletal muscle [MA:0003148] normal [MPATH:458]
HOM M #1 Brain [MA:0000168] 0 0
HOM F #4 Bone marrow [MA:0000134] 0 0
HOM M #3 Thyroid normal [MPATH:458]
HOM F #2 Sciatic nerve [MA:0001172] normal [MPATH:458]
HOM F #2 Ear [MA:0000236] 0 0
HOM M #1 Salivary gland [MA:0000346] normal [MPATH:458]
HOM M #3 Salivary gland [MA:0000346] 0 0
HOM F #2 Eye with optic nerve developmental and structural abnormality [MPATH:55] localized
HOM M #3 Kidney [MA:0000368] 0 0
HOM F #2 Sternum [MA:0001331] normal [MPATH:458]
HOM M #1 Tongue [MA:0000347] 0 0
HOM M #3 Small intestine [MA:0000337] normal [MPATH:458]
HOM F #4 Uterus [MA:0000389] 0 0
HOM M #3 Esophagus [MA:0000352] normal [MPATH:458]
HOM M #1 Adrenal gland [MA:0000116] normal [MPATH:458]
HOM F #4 Liver [MA:0000358] 0 0
HOM M #1 Bone marrow [MA:0000134] normal [MPATH:458]
HOM M #1 Large intestine [MA:0000333] normal [MPATH:458]
HOM M #3 Brain [MA:0000168] normal [MPATH:458]
HOM M #1 Sciatic nerve [MA:0001172] 0 0
HOM F #2 Bone marrow [MA:0000134] 0 0
HOM M #1 Gall bladder [MA:0000356] normal [MPATH:458]
HOM F #2 Urinary bladder [MA:0000380] 0 0
HOM M #1 Esophagus [MA:0000352] 0 0
HOM F #4 Large intestine [MA:0000333] 0 0
HOM F #4 Ear [MA:0000236] 0 0
HOM F #2 Uterus [MA:0000389] 0 0
HOM F #4 Esophagus [MA:0000352] normal [MPATH:458]
HOM M #3 Pancreas [MA:0000120] normal [MPATH:458]
HOM F #4 Lymph node [MA:0000139] neoplasm [MPATH:218] lymphoid neoplasms MPATH:513 multi-localised
HOM M #3 Small intestine [MA:0000337] 0 0
HOM M #1 Spinal cord [MA:0000216] normal [MPATH:458]
HOM F #4 Sciatic nerve [MA:0001172] normal [MPATH:458]
HOM F #2 Femur [MA:0001359] 0 0
HOM M #1 Urinary bladder [MA:0000380] normal [MPATH:458]
HOM M #1 Heart [MA:0000072] normal [MPATH:458]
HOM M #1 Salivary gland [MA:0000346] 0 0
HOM F #4 Eye with optic nerve 0 0
HOM M #1 Spleen [MA:0000141] normal [MPATH:458]
HOM M #1 Eye with optic nerve 1 0 multifocal retinal dysplasia.
HOM F #4 Sternum [MA:0001331] normal [MPATH:458]
HOM M #3 Liver [MA:0000358] 0 0
HOM F #4 Adrenal gland [MA:0000116] normal [MPATH:458]
HOM F #4 Thymus [MA:0000142] normal [MPATH:458]
HOM M #3 Epididymis [MA:0000397] normal [MPATH:458]
HOM F #2 Bone marrow [MA:0000134] normal [MPATH:458]
HOM M #3 Lymph node [MA:0000139] normal [MPATH:458]
HOM M #3 Sciatic nerve [MA:0001172] normal [MPATH:458]
HOM M #1 Thyroid 0 0
HOM M #1 Gall bladder [MA:0000356] 0 0
HOM F #2 Adrenal gland [MA:0000116] 0 0
HOM F #2 Ear [MA:0000236] normal [MPATH:458]
HOM F #2 Tongue [MA:0000347] normal [MPATH:458]
HOM F #4 Pancreas [MA:0000120] normal [MPATH:458]
HOM F #2 Kidney [MA:0000368] 0 0
HOM M #3 Gall bladder [MA:0000356] normal [MPATH:458]
HOM F #2 Thyroid normal [MPATH:458]
HOM F #2 Femur [MA:0001359] normal [MPATH:458]
HOM M #3 Urinary bladder [MA:0000380] normal [MPATH:458]
HOM F #4 Kidney [MA:0000368] normal [MPATH:458]
HOM F #4 Gall bladder [MA:0000356] normal [MPATH:458]
HOM M #3 Large intestine [MA:0000333] normal [MPATH:458]
HOM F #4 Small intestine [MA:0000337] 0 0
HOM F #4 Salivary gland [MA:0000346] 0 0
HOM F #2 Nasal cavity [MA:0000284] normal [MPATH:458]
HOM F #4 Large intestine [MA:0000333] normal [MPATH:458]
HOM F #2 Liver [MA:0000358] 0 0
HOM M #3 Thymus [MA:0000142] normal [MPATH:458]
HOM F #2 Small intestine [MA:0000337] normal [MPATH:458]
HOM F #2 Large intestine [MA:0000333] normal [MPATH:458]
HOM M #1 Heart [MA:0000072] 0 0
HOM F #2 Brain [MA:0000168] normal [MPATH:458]
HOM F #4 Trachea [MA:0000441] normal [MPATH:458]
HOM M #1 Liver [MA:0000358] 0 0
HOM M #3 Eye with optic nerve 1 0 Focal retinal dysplasia.
HOM F #2 Heart [MA:0000072] 0 0
HOM M #3 Epididymis [MA:0000397] 0 0
HOM M #1 Brain [MA:0000168] normal [MPATH:458]
HOM F #2 Pancreas [MA:0000120] 0 0
HOM F #2 Salivary gland [MA:0000346] normal [MPATH:458]
HOM M #3 Bone marrow [MA:0000134] normal [MPATH:458]
HOM F #4 Mammary gland [MA:0000145] 0 0
HOM M #3 Sternum [MA:0001331] 0 0
HOM F #4 Liver [MA:0000358] normal [MPATH:458]
HOM F #4 Spinal cord [MA:0000216] 0 0
HOM M #3 Testes 0 0
HOM F #4 Bone marrow [MA:0000134] normal [MPATH:458]
HOM F #2 Sternum [MA:0001331] 0 0
HOM M #3 Spinal cord [MA:0000216] 0 0
HOM M #1 Thyroid normal [MPATH:458]
HOM M #3 Pancreas [MA:0000120] 0 0
HOM F #4 Femur [MA:0001359] 0 0
HOM M #3 Trachea [MA:0000441] normal [MPATH:458]
HOM F #2 Esophagus [MA:0000352] normal [MPATH:458]
HOM M #1 Femur [MA:0001359] normal [MPATH:458]
HOM M #3 Femur [MA:0001359] 0 0
HOM F #2 Tooth [MA:0000348] normal [MPATH:458]
HOM M #1 Ear [MA:0000236] normal [MPATH:458]
HOM M #1 Sternum [MA:0001331] 0 0
HOM F #4 Pancreas [MA:0000120] 0 0
HOM M #1 Pancreas [MA:0000120] 0 0
HOM M #3 Prostate normal [MPATH:458]
HOM F #2 Spinal cord [MA:0000216] 0 0
HOM M #3 Sternum [MA:0001331] normal [MPATH:458]
HOM M #1 Femur [MA:0001359] 0 0
HOM M #3 Testes normal [MPATH:458]
HOM M #1 Prostate 0 0
HOM F #4 Eye with optic nerve normal [MPATH:458]
HOM M #1 Spinal cord [MA:0000216] 0 0
HOM M #1 Small intestine [MA:0000337] normal [MPATH:458]
HOM M #3 Prostate 0 0
HOM F #2 Mammary gland [MA:0000145] 0 0
HOM M #3 Adrenal gland [MA:0000116] normal [MPATH:458]
HOM F #4 Thyroid 0 0
HOM F #4 Gall bladder [MA:0000356] 0 0

Associated histopathology images

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter