Histopathology data for Hook1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #4 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #2 Mammary gland [MA:0000145] Not applicable
HOM F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #2 Tooth [MA:0000348] normal [MPATH:458] 0 0
HOM F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #1 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #3 Tooth [MA:0000348] normal [MPATH:458] 0 0
HOM F #1 Seminal vesicle [MA:0000410] Not applicable
HOM F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM M #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Thyroid normal [MPATH:458] 0 0
HOM F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #4 Tooth [MA:0000348] normal [MPATH:458] 0 0
HOM M #3 Testes 3 1 bilateral chronic Abnormal spermatogenesis
HOM F #1 Prostate Not applicable
HOM F #1 Tongue [MA:0000347] normal [MPATH:458] 0 0
HOM M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #4 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #1 Eye with optic nerve normal [MPATH:458] 0 0
HOM M #3 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #3 Nasal cavity [MA:0000284] normal [MPATH:458] 0 0
HOM M #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Thyroid normal [MPATH:458] 0 0
HOM M #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM M #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #3 Ear [MA:0000236] normal [MPATH:458] 0 0
HOM F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Ear [MA:0000236] normal [MPATH:458] 0 0
HOM F #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #3 Tongue [MA:0000347] normal [MPATH:458] 0 0
HOM M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #4 Prostate Not applicable
HOM F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #4 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #4 Tongue [MA:0000347] normal [MPATH:458] 0 0
HOM M #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM M #2
HOM M #2 Ovary [MA:0000384] Not applicable
HOM M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Nasal cavity [MA:0000284] normal [MPATH:458] 0 0
HOM M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Uterus [MA:0000389] Not applicable
HOM M #3 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Testes Not applicable
HOM M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Prostate normal [MPATH:458] 0 0
HOM F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #2 Tongue [MA:0000347] normal [MPATH:458] 0 0
HOM M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #3
HOM F #4 Ear [MA:0000236] normal [MPATH:458] 0 0
HOM F #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #4 Epididymis [MA:0000397] Not applicable
HOM M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Ovary [MA:0000384] Not applicable
HOM M #2 Uterus [MA:0000389] Not applicable
HOM M #2 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #4 Thyroid normal [MPATH:458] 0 0
HOM M #2 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM M #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM F #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Tooth [MA:0000348] normal [MPATH:458] 0 0
HOM M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #3 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458]
HOM F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #4 Nasal cavity [MA:0000284] normal [MPATH:458] 0 0
HOM F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #4 Testes Not applicable
HOM F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #1 Ear [MA:0000236] normal [MPATH:458] 0 0
HOM F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM F #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM M #3 Sternum [MA:0001331] 0 0
HOM M #3 Sternum [MA:0001331] 0 0
HOM M #3 Thyroid normal [MPATH:458] 0 0
HOM M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM F #4 Seminal vesicle [MA:0000410] Not applicable
HOM M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #3 Prostate normal [MPATH:458] 0 0
HOM M #3 Stomach [MA:0000353] inflammation [MPATH:212] 1 0 acute Suppurative gastritis
HOM M #2 Nasal cavity [MA:0000284] normal [MPATH:458] 0 0
HOM F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Testes 3 1 chronic bilateral Abnormal spermatogenesis
HOM F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #1 Epididymis [MA:0000397] Not applicable

Associated histopathology images

Hook1
homozygote
Stomach MA:0000353
MA:0000353 stomach
Hook1em1(IMPC)Tcp
experimental
Hook1
homozygote
Testes MA:0000411
MA:0000411 testis
Hook1em1(IMPC)Tcp
experimental
Hook1
homozygote
Testes MA:0000411
MA:0000411 testis
Hook1em1(IMPC)Tcp
experimental

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