Histopathology data for Hecw1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #2 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #2 Ear [MA:0000236] Not applicable
HOM M #2 Bone [MA:0001459]
HOM F #4 Sternum [MA:0001331] Not applicable 0
HOM F #4 Liver [MA:0000358] Not applicable 0
HOM M #2 Eye with optic nerve Not applicable 0
HOM F #1 Spinal cord [MA:0000216] Not applicable 0
HOM M #2 Salivary gland [MA:0000346] Not applicable 0
HOM F #4 Spinal cord [MA:0000216] Not applicable 0
HOM M #2 Esophagus [MA:0000352] Not applicable 0
HOM M #2 Bone marrow [MA:0000134] Not applicable 0
HOM F #1 Prostate Not applicable 0
HOM F #1 Sternum [MA:0001331] Not applicable 0
HOM M #3 Large intestine [MA:0000333] Not applicable 0
HOM M #2 Uterus [MA:0000389] Not applicable 0
HOM F #4 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #4 Prostate Not applicable 0
HOM F #4 Knee joint [MA:0000471] Not applicable 0
HOM F #1 Epididymis [MA:0000397] Not applicable 0
HOM F #4 Tongue [MA:0000347] Not applicable 0
HOM M #3 Femur [MA:0001359] Not applicable 0
HOM M #2 Adrenal gland [MA:0000116] Not applicable 0
HOM F #4 Skin [MA:0000151] Not applicable 0
HOM F #4 Thyroid Not applicable 0
HOM M #2 Brain [MA:0000168] Not applicable 0
HOM F #4 Brain [MA:0000168] Not applicable 0
HOM F #1 Trigeminal V nerve [MA:0001100] Not applicable
HOM M #2 Skin [MA:0000151] Not applicable 0
HOM F #4 Pancreas [MA:0000120] Not applicable 0
HOM M #2 Large intestine [MA:0000333] Not applicable 0
HOM M #3 Stomach [MA:0000353] Not applicable 0
HOM M #2 Lung [MA:0000415] Not applicable 0
HOM M #3 Eye with optic nerve Not applicable 0
HOM F #1 Mammary gland [MA:0000145] Not applicable
HOM F #1 Liver [MA:0000358] Not applicable 0
HOM F #1 Thymus [MA:0000142] Not applicable 0
HOM F #1 Brain [MA:0000168] Not applicable 0
HOM F #1 Trachea [MA:0000441] Not applicable
HOM F #4 Nasal cavity [MA:0000284] Not applicable 0
HOM M #3 Brown adipose tissue [MA:0000057] Not applicable
HOM M #3 Testes Not applicable 0
HOM F #1 Knee joint [MA:0000471] Not applicable 0
HOM F #1 Uterus [MA:0000389] Not applicable 0
HOM M #3 Urinary bladder [MA:0000380] Not applicable 0
HOM F #4 Lung [MA:0000415] Not applicable 0
HOM F #1 Thyroid Not applicable 0
HOM F #1 Tongue [MA:0000347] Not applicable 0
HOM M #3 Seminal vesicle [MA:0000410] Not applicable 0
HOM F #1 Salivary gland [MA:0000346] Not applicable 0
HOM M #3 Heart [MA:0000072] Not applicable 0
HOM F #4 Trachea [MA:0000441] Not applicable 0
HOM M #2 Prostate Not applicable 0
HOM F #1 Eye with optic nerve Not applicable 0
HOM M #2 Spinal cord [MA:0000216] Not applicable 0
HOM M #3 Esophagus [MA:0000352] Not applicable 0
HOM M #2 Tongue [MA:0000347] Not applicable 0
HOM M #3 Lymph node [MA:0000139] Not applicable
HOM M #3 Spleen [MA:0000141] Not applicable 0
HOM M #3 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #3 Ovary [MA:0000384] Not applicable 0
HOM F #4 Eye with optic nerve Not applicable 0
HOM M #2 Gall bladder [MA:0000356] Not applicable 0
HOM F #4 Bone [MA:0001459]
HOM F #1 Heart [MA:0000072] Not applicable 0
HOM F #1 Spleen [MA:0000141] Not applicable 0
HOM F #4 Uterus [MA:0000389] Not applicable 0
HOM F #1 Ovary [MA:0000384] Not applicable 0
HOM M #2 Liver [MA:0000358] Not applicable 0
HOM F #1 Skeletal muscle [MA:0003148] Not applicable 0
HOM F #4 Small intestine [MA:0000337] Not applicable 0
HOM M #3 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #1 Esophagus [MA:0000352] Not applicable 0
HOM M #2 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #4 Adrenal gland [MA:0000116] Not applicable 0
HOM F #4 Gall bladder [MA:0000356] Not applicable 0
HOM F #4 Kidney [MA:0000368] Not applicable 0
HOM F #1 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #1 Pancreas [MA:0000120] Not applicable 0
HOM M #3 Salivary gland [MA:0000346] Not applicable 0
HOM F #4 Bone marrow [MA:0000134] Not applicable 0
HOM F #4 Ear [MA:0000236] Not applicable
HOM F #4 Epididymis [MA:0000397] Not applicable 0
HOM M #2 Epididymis [MA:0000397] Not applicable 0
HOM M #2 Lymph node [MA:0000139] Not applicable 0
HOM M #3 Pancreas [MA:0000120] Not applicable 0
HOM M #3 Gall bladder [MA:0000356] Not applicable 0
HOM F #1 Urinary bladder [MA:0000380] Not applicable 0
HOM M #3 Epididymis [MA:0000397] Not applicable 0
HOM M #2 Tibia [MA:0001361] Not significant
HOM F #4 Urinary bladder [MA:0000380] Not applicable 0
HOM F #4 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #2 Small intestine [MA:0000337] Not applicable 0
HOM M #2 Trachea [MA:0000441] Not applicable 0
HOM M #3 Prostate Not applicable 0
HOM M #2 Kidney [MA:0000368] Not applicable 0
HOM F #1 Stomach [MA:0000353] Not applicable 0
HOM M #3 Nasal cavity [MA:0000284] Not applicable 0
HOM M #2 Mammary gland [MA:0000145] Not applicable
HOM M #3 Sternum [MA:0001331] Not applicable 0
HOM M #2 Thymus [MA:0000142] Not applicable
HOM M #3 Thymus [MA:0000142] Not applicable 0
HOM M #2 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #1 Large intestine [MA:0000333] Not applicable 0
HOM M #3 Trachea [MA:0000441] Not applicable 0
HOM F #1 Testes Not applicable 0
HOM F #4 Ovary [MA:0000384] Not applicable 0
HOM M #2 Tooth [MA:0000348] Not applicable 0
HOM F #1 Brown adipose tissue [MA:0000057] Not applicable
HOM M #2 Testes Not applicable 0
HOM M #3 Spinal cord [MA:0000216] Not applicable 0
HOM M #3 Tongue [MA:0000347] Not applicable 0
HOM F #1 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Thyroid Not applicable 0
HOM F #4 Testes Not applicable 0
HOM M #2 Ovary [MA:0000384] Not applicable 0
HOM F #4 Tibia [MA:0001361] Not significant
HOM F #1 Femur [MA:0001359] Not applicable 0
HOM M #2 Stomach [MA:0000353] Not applicable 0
HOM F #4 Stomach [MA:0000353] Not applicable 0
HOM F #4 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #3 Knee joint [MA:0000471] Not applicable 0
HOM M #2 Heart [MA:0000072] Not applicable 0
HOM F #1 Lymph node [MA:0000139] Not applicable 0
HOM F #4 Large intestine [MA:0000333] Not applicable 0
HOM F #4 Heart [MA:0000072] Not applicable 0
HOM F #4 Tooth [MA:0000348] Not applicable 0
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM M #3 Liver [MA:0000358] Not applicable 0
HOM M #2 Nasal cavity [MA:0000284] Not applicable 0
HOM F #1 Small intestine [MA:0000337] Not applicable 0
HOM M #3 Small intestine [MA:0000337] Not applicable 0
HOM M #3 Brain [MA:0000168] Not applicable 0
HOM M #2 Knee joint [MA:0000471] Not applicable 0
HOM F #4 Thymus [MA:0000142] Not applicable 0
HOM F #1 Ear [MA:0000236] Not applicable
HOM F #1 Bone [MA:0001459]
HOM M #3 Lung [MA:0000415] Not applicable 0
HOM M #3 Bone marrow [MA:0000134] Not applicable 0
HOM F #4 Mammary gland [MA:0000145] Not applicable
HOM F #1 Tibia [MA:0001361] Not significant
HOM M #2 Pancreas [MA:0000120] Not applicable 0
HOM M #3 Uterus [MA:0000389] Not applicable 0
HOM F #4 Salivary gland [MA:0000346] Not applicable 0
HOM M #3 Trigeminal V nerve [MA:0001100] Not applicable
HOM M #3 Tooth [MA:0000348] Not applicable 0
HOM M #3 Bone [MA:0001459]
HOM F #1 Bone marrow [MA:0000134] Not applicable 0
HOM M #3 Tibia [MA:0001361] Not significant
HOM M #2 Urinary bladder [MA:0000380] Not applicable 0
HOM F #4 Brown adipose tissue [MA:0000057] Not applicable
HOM M #2 Brown adipose tissue [MA:0000057] Not applicable
HOM F #1 Lung [MA:0000415] Not applicable 0
HOM M #2 Seminal vesicle [MA:0000410] Not applicable 0
HOM F #4 Lymph node [MA:0000139] Not applicable 0
HOM F #1 Nasal cavity [MA:0000284] Not applicable 0
HOM F #4 Spleen [MA:0000141] Not applicable 0
HOM F #1 Tooth [MA:0000348] Not applicable 0
HOM M #2 Thyroid Not applicable 0
HOM F #1 Gall bladder [MA:0000356] Not applicable 0
HOM F #4 Femur [MA:0001359] Not applicable 0
HOM F #1 Kidney [MA:0000368] Not applicable 0
HOM M #2 Spleen [MA:0000141] Not applicable 0
HOM F #4 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #3 Ear [MA:0000236] Not applicable
HOM F #1 Adrenal gland [MA:0000116] Not applicable 0
HOM M #2 Femur [MA:0001359] Not applicable
HOM M #3 Skin [MA:0000151] Not applicable 0
HOM F #4 Esophagus [MA:0000352] Not applicable 0
HOM M #3 Kidney [MA:0000368] Not applicable 0
HOM F #1 Skin [MA:0000151] Not applicable 0
HOM M #2 Sternum [MA:0001331] Not applicable 0
HOM M #3 Adrenal gland [MA:0000116] Not applicable 0

Associated histopathology images

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter