Histopathology data for Greb1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #1
HOM M #2 Testes normal [MPATH:458] 0 0
HOM F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Prostate normal [MPATH:458] 0 0
HOM M #3 Ovary [MA:0000384] Not applicable
HOM M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #3 Uterus [MA:0000389] Not applicable
HOM F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2
HOM F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Epididymis [MA:0000397] Not applicable
HOM F #4 Epididymis [MA:0000397] Not applicable
HOM M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #4
HOM M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #1 Testes Not applicable
HOM F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #2 Mammary gland [MA:0000145] Not applicable
HOM M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #4 Testes Not applicable
HOM M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Thyroid normal [MPATH:458] 0 0
HOM F #4 Thyroid normal [MPATH:458] 0 0
HOM F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #4 Prostate Not applicable
HOM F #1 Prostate Not applicable
HOM M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #2 Eye with optic nerve developmental and structural abnormality [MPATH:55] 3 0 chronic multi-localised Detachment of inner limiting membrane, retina.
HOM F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #1 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM F #1 Eye with optic nerve developmental and structural abnormality [MPATH:55] 0 0 chronic localized Persistent hyaloid artery.
HOM F #4 Eye with optic nerve developmental and structural abnormality [MPATH:55] 3 0 multi-localised chronic Detachment of inner limiting membrane, retina.
HOM M #2 Uterus [MA:0000389] Not applicable
HOM F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM M #2 Ovary [MA:0000384] Not applicable
HOM M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #4 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HOM M #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM M #3 Thyroid normal [MPATH:458] 0 0
HOM F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Thyroid normal [MPATH:458] 0 0
HOM M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #3 Testes normal [MPATH:458] 0 0
HOM F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #4 Seminal vesicle [MA:0000410] Not applicable
HOM M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #2 Prostate normal [MPATH:458] 0 0
HOM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Seminal vesicle [MA:0000410] Not applicable
HOM F #4 Liver [MA:0000358] normal [MPATH:458] 0 0

Associated histopathology images

Greb1
homozygote
Eye with optic nerve MA:0000276
MA:0000261 eye
Greb1tm1b(KOMP)Wtsi
experimental
Greb1
homozygote
Eye with optic nerve MA:0000276
MA:0000261 eye
Greb1tm1b(KOMP)Wtsi
experimental
Greb1
homozygote
Eye with optic nerve MA:0000276
MA:0000261 eye
Greb1tm1b(KOMP)Wtsi
experimental

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