Histopathology data for Gprc5b

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Sternum [MA:0001331] displacement and deformity [MPATH:67] Not applicable 0 focally extensive Sternal fissure
HOM M #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Eye with optic nerve normal [MPATH:458] 0 0
HOM M #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #2 Prostate normal [MPATH:458] 0 0
HOM F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #3 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 distributed Lymphoid hyperplasia
HOM M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM M #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #2
HOM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #2 Thyroid normal [MPATH:458] 0 0
HOM F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #2 Brain [MA:0000168] process of degenerative change [MPATH:14] 3 0 hydrocephalus MPATH:639 distributed Dilation of the brain ventricles
HOM M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #4 Skin [MA:0000151] inflammation [MPATH:212] 1 0 multi-localised Epidermitis, focal
HOM F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #4 Testes normal [MPATH:458] 0 0
HOM M #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM M #4 Prostate normal [MPATH:458] 0 0
HOM F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #4 Sternum [MA:0001331] process of degenerative change [MPATH:14] Not applicable 0 chronic focally extensive Sternal dislocation with reparative chondroid hyperplasia ('calus')
HOM M #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #4 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM M #4
HOM F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #2 Testes normal [MPATH:458] 0 0
HOM F #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #3 Sternum [MA:0001331] process of degenerative change [MPATH:14] Not applicable 0 chronic focally extensive Sternal dislocation with reparative chondroid hyperplasia ('calus')
HOM F #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM M #4 Eye with optic nerve normal [MPATH:458] 0 0
HOM M #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #4 Thyroid normal [MPATH:458] 0 0
HOM M #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #4 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM F #3 Heart [MA:0000072] fibrosis [MPATH:181] 1 0 chronic focally extensive Right auricular epicardial fibrosis and mesothelial hyperplasia, focal
HOM F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #3 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Thyroid normal [MPATH:458] 0 0
HOM M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM F #3 Thyroid developmental and structural abnormality [MPATH:55] Not applicable 0 focally extensive Ectopic thymus
HOM F #3

Associated histopathology images

Gprc5b
homozygote
Sternum MA:0001331
MA:0001331 sternum
Gprc5btm1a(EUCOMM)Wtsi
experimental
Gprc5b
homozygote
Sternum MA:0001331
MA:0001331 sternum
Gprc5btm1a(EUCOMM)Wtsi
experimental
Gprc5b
homozygote
Heart MA:0000075
MA:0000072 heart
Gprc5btm1a(EUCOMM)Wtsi
experimental
Gprc5b
homozygote
Sternum MA:0001331
MA:0001331 sternum
Gprc5btm1a(EUCOMM)Wtsi
experimental

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