Histopathology data for Egfr

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET M #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #1 Prostate normal [MPATH:458] 0 0
HET M #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #2 Spleen [MA:0000141] hyperplasia [MPATH:134] 2 0 extramedullary hemopoiesis MPATH:595 multifocal to coalescing mild erythropoiesis
HET F #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #1 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Testes normal [MPATH:458] 0 0
HET M #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #4 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET F #3 Thyroid normal [MPATH:458] 0 0
HET M #4 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #1 Lymph node [MA:0000139] neoplasm [MPATH:218] Not applicable 0 lymphoid neoplasms MPATH:513 Lymphoma
HET F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #3 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 distributed Lymphoid hyperplasia
HET M #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #4 Eye with optic nerve 1 0 Retinal folding (dysplasia)
HET M #4 Eye with optic nerve normal [MPATH:458] developmental and structural abnormality [MPATH:55] multi-localised
HET F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #4 Eye with optic nerve 0 0
HET M #1 Thyroid normal [MPATH:458] 0 0
HET F #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #2 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #1 Testes normal [MPATH:458] 0 0
HET F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #2 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 distributed Lymphoid hyperplasia
HET F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #4 Lymph node [MA:0000139] hyperplasia [MPATH:134] 2 0 distributed Lymphoid hyperplasia
HET M #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #1 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #4 Thyroid normal [MPATH:458] 0 0
HET F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #2 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET M #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] 0 0
HET M #1 Thymus [MA:0000142] developmental and structural abnormality [MPATH:55] 1 0 cyst MPATH:62 localized Epithelial cyst
HET M #1 Stomach [MA:0000353] inflammation [MPATH:212] 2 0 multi-localised Moderate neutrophilic gastritis with epithelial proteinosis
HET M #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #1 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #4 Prostate normal [MPATH:458] 0 0
HET F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #3 Liver [MA:0000358] lipid deposition [MPATH:42] 2 0 steatosis MPATH:622 multifocal to coalescing hepatic steatosis
HET F #2 Thyroid normal [MPATH:458] 0 0
HET F #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0

Associated histopathology images

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