Histopathology data for Aldh18a1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET M #2 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET M #1 Thyroid normal [MPATH:458] 0 0
HET F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #3 Thyroid normal [MPATH:458] 0 0
HET M #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET F #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #2 Testes normal [MPATH:458] 0 0
HET M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #4 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #3 Liver [MA:0000358] lipid deposition [MPATH:42] 1 0 multi-localised minimal hepatic steatosis
HET M #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #1 Salivary gland [MA:0000346] inflammation [MPATH:212] 1 0 multi-localised Interstitial inflammatory aggregates
HET M #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #1 Prostate normal [MPATH:458] 0 0
HET F #4 Adrenal gland [MA:0000116] developmental and structural abnormality [MPATH:55] Not applicable 0 localized accessory adrenal cortical tissue
HET M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #4 Liver [MA:0000358] lipid deposition [MPATH:42] 2 0 multi-localised moderate hepatic steatosis
HET M #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #2 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #3 Adrenal gland [MA:0000116] developmental and structural abnormality [MPATH:55] Not applicable 0 localized accessory adrenal cortical tissue
HET M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #2 Eye with optic nerve normal [MPATH:458] 0 0
HET M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #2 Thyroid normal [MPATH:458] 0 0
HET M #2 Prostate normal [MPATH:458] 0 0
HET M #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #1 Testes normal [MPATH:458] 0 0
HET F #4 Eye with optic nerve normal [MPATH:458] 0 0
HET M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #1 Eye with optic nerve normal [MPATH:458] 0 0
HET F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Brain [MA:0000168] process of degenerative change [MPATH:14] 1 0 bilateral Dilation of the brain ventricles
HET F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #3 Eye with optic nerve normal [MPATH:458] 0 0
HET M #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #1 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #4 Thyroid normal [MPATH:458] 0 0
HET F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0

Associated histopathology images

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