Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data Eye with optic nerve - developmental and structural abnormality Spns2 homozygote female Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:2384936?anatomy="Eye with optic nerve" Eye with optic nerve - inflammation Spns2 homozygote female Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:2384936?anatomy="Eye with optic nerve" Eye with optic nerve - developmental and structural abnormality Spns2 homozygote female Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:2384936?anatomy="Eye with optic nerve" Eye with optic nerve - inflammation Spns2 homozygote female Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:2384936?anatomy="Eye with optic nerve" decreased leukocyte cell number Spns2 homozygote male Early adult Hematology White blood cell count WTSI IMPC 4.08E-39 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_HEM_001_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_001_001&phenotyping_center=WTSI absent pinna reflex Spns2 homozygote female Early adult Modified SHIRPA Startle Response WTSI EuroPhenome 5.54E-30 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_008_001_013&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_008_001¶meter_stable_id=M-G-P_008_001_013&phenotyping_center=WTSI decreased leukocyte cell number Spns2 homozygote female Early adult Hematology White blood cell count WTSI IMPC 2.11E-29 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_HEM_001_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_001_001&phenotyping_center=WTSI abnormal eye pigmentation Spns2 homozygote female Early adult Dysmorphology Eye colouration WTSI EuroPhenome 4.04E-25 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_026_001_019&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_026_001¶meter_stable_id=M-G-P_026_001_019&phenotyping_center=WTSI increased circulating bilirubin level Spns2 homozygote male Early adult Clinical Chemistry Total bilirubin WTSI EuroPhenome 5.29E-24 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_022&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_022&phenotyping_center=WTSI corneal opacity Spns2 homozygote female Early adult Slit Lamp cornea opacity WTSI EuroPhenome 1.34E-21 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_007&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_007&phenotyping_center=WTSI corneal vascularization Spns2 homozygote female Early adult Slit Lamp cornea vascularisation WTSI EuroPhenome 4.21E-21 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_008&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_008&phenotyping_center=WTSI abnormal cornea morphology Spns2 homozygote female Early adult Slit Lamp cornea WTSI EuroPhenome 1.24E-20 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_006&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_006&phenotyping_center=WTSI decreased leukocyte cell number Spns2 homozygote female Early adult Haematology test White blood cell-count WTSI EuroPhenome 1.89E-17 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_016_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_016_001¶meter_stable_id=M-G-P_016_001_001&phenotyping_center=WTSI corneal vascularization Spns2 homozygote male Early adult Slit Lamp cornea vascularisation WTSI EuroPhenome 7.49E-17 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_008&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_008&phenotyping_center=WTSI absent pinna reflex Spns2 homozygote male Early adult Modified SHIRPA Startle Response WTSI EuroPhenome 2.23E-16 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_008_001_013&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_008_001¶meter_stable_id=M-G-P_008_001_013&phenotyping_center=WTSI corneal opacity Spns2 homozygote male Early adult Slit Lamp cornea opacity WTSI EuroPhenome 3.42E-14 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_007&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_007&phenotyping_center=WTSI abnormal cornea morphology Spns2 homozygote male Early adult Slit Lamp cornea WTSI EuroPhenome 2.33E-13 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_006&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_006&phenotyping_center=WTSI corneal opacity Spns2 homozygote female Early adult Eye Morphology Corneal opacity WTSI IMPC 5.05E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_008_001&phenotyping_center=WTSI corneal vascularization Spns2 homozygote female Early adult Eye Morphology Corneal vascularization WTSI IMPC 5.05E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_009_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_009_001&phenotyping_center=WTSI corneal opacity Spns2 homozygote male Early adult Eye Morphology Corneal opacity WTSI IMPC 9.77E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_008_001&phenotyping_center=WTSI abnormal cornea morphology Spns2 homozygote male Early adult Eye Morphology Cornea WTSI IMPC 9.77E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_007_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_007_001&phenotyping_center=WTSI corneal vascularization Spns2 homozygote male Early adult Eye Morphology Corneal vascularization WTSI IMPC 9.77E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_009_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_009_001&phenotyping_center=WTSI absent pinna reflex Spns2 homozygote male Early adult Combined SHIRPA and Dysmorphology Startle response WTSI IMPC 9.77E-11 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=MGP_CSD_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=MGP_CSD_001¶meter_stable_id=MGP_CSD_008_001&phenotyping_center=WTSI abnormal cornea morphology Spns2 homozygote female Early adult Eye Morphology Cornea WTSI IMPC 8.08E-10 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_007_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_007_001&phenotyping_center=WTSI abnormal eye pigmentation Spns2 homozygote male Early adult Dysmorphology Eye colouration WTSI EuroPhenome 1.06E-9 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_026_001_019&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_026_001¶meter_stable_id=M-G-P_026_001_019&phenotyping_center=WTSI decreased leukocyte cell number Spns2 homozygote male Early adult Haematology test White blood cell-count WTSI EuroPhenome 1.3E-9 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_016_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_016_001¶meter_stable_id=M-G-P_016_001_001&phenotyping_center=WTSI abnormal eye morphology Spns2 homozygote female Early adult Slit Lamp Eye WTSI EuroPhenome 6.79E-9 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_001&phenotyping_center=WTSI narrow eye opening Spns2 homozygote male Early adult Eye Morphology Narrow eye opening WTSI IMPC 8.6E-9 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_006_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_006_001&phenotyping_center=WTSI trunk curl Spns2 homozygote male Early adult Combined SHIRPA and Dysmorphology Trunk curl WTSI IMPC 8.6E-9 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=MGP_CSD_003_001&pipeline_stable_id=MGP_001&procedure_stable_id=MGP_CSD_001¶meter_stable_id=MGP_CSD_003_001&phenotyping_center=WTSI abnormal eye size Spns2 homozygote male Early adult Dysmorphology Eye size WTSI EuroPhenome 3.31E-8 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_026_001_018&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_026_001¶meter_stable_id=M-G-P_026_001_018&phenotyping_center=WTSI absent pinna reflex Spns2 homozygote female Early adult Combined SHIRPA and Dysmorphology Startle response WTSI IMPC 2.64E-7 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=MGP_CSD_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=MGP_CSD_001¶meter_stable_id=MGP_CSD_008_001&phenotyping_center=WTSI decreased circulating HDL cholesterol level Spns2 homozygote male Early adult Clinical Chemistry HDL-cholesterol WTSI EuroPhenome 4.12E-7 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_023&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_023&phenotyping_center=WTSI abnormal eye size Spns2 homozygote female Early adult Dysmorphology Eye size WTSI EuroPhenome 7.11E-7 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_026_001_018&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_026_001¶meter_stable_id=M-G-P_026_001_018&phenotyping_center=WTSI decreased circulating cholesterol level Spns2 homozygote male Early adult Clinical Chemistry Total cholesterol WTSI EuroPhenome 7.41E-7 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_017&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_017&phenotyping_center=WTSI increased circulating creatine kinase level Spns2 homozygote female Early adult Clinical Chemistry Creatine kinase WTSI EuroPhenome 1.68E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_020&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_020&phenotyping_center=WTSI increased bone mineral density Spns2 homozygote not_considered Early adult Dexa-scan analysis Bone Mineral Density (excluding skull) WTSI EuroPhenome 1.71E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_005_001_004&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_005_001¶meter_stable_id=M-G-P_005_001_004&phenotyping_center=WTSI excessive tearing Spns2 homozygote female Early adult Modified SHIRPA Lacrimation WTSI EuroPhenome 5.58E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_008_001_006&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_008_001¶meter_stable_id=M-G-P_008_001_006&phenotyping_center=WTSI abnormal iris morphology Spns2 homozygote male Early adult Slit Lamp Iris/Pupil WTSI EuroPhenome 6.88E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_011&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_011&phenotyping_center=WTSI abnormal eyelid aperture Spns2 homozygote male Early adult Slit Lamp Eyelid closure WTSI EuroPhenome 7.24E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_005&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_005&phenotyping_center=WTSI trunk curl Spns2 homozygote female Early adult Combined SHIRPA and Dysmorphology Trunk curl WTSI IMPC 7.92E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=MGP_CSD_003_001&pipeline_stable_id=MGP_001&procedure_stable_id=MGP_CSD_001¶meter_stable_id=MGP_CSD_003_001&phenotyping_center=WTSI decreased circulating LDL cholesterol level Spns2 homozygote male Early adult Clinical Chemistry LDL-cholesterol WTSI EuroPhenome 8.86E-6 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_024&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_024&phenotyping_center=WTSI increased mean corpuscular hemoglobin Spns2 homozygote female Early adult Hematology Mean corpuscular hemoglobin WTSI IMPC 1.22E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_HEM_006_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_006_001&phenotyping_center=WTSI decreased circulating glucose level Spns2 homozygote male Early adult Clinical Chemistry Glucose WTSI EuroPhenome 1.45E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_001&phenotyping_center=WTSI abnormal eye morphology Spns2 homozygote male Early adult Slit Lamp Eye WTSI EuroPhenome 1.46E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_001&phenotyping_center=WTSI abnormal pupil morphology Spns2 homozygote not_considered Early adult Slit Lamp Iris/Pupil shape WTSI EuroPhenome 1.75E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_013&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_013&phenotyping_center=WTSI decreased bone mineral content Spns2 homozygote male Early adult Body Composition (DEXA lean/fat) Bone Mineral Content (excluding skull) WTSI IMPC 3.36E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_DXA_005_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_005_001&phenotyping_center=WTSI abnormal eyelid aperture Spns2 homozygote female Early adult Slit Lamp Eyelid closure WTSI EuroPhenome 3.43E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_014_001_005&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_014_001¶meter_stable_id=M-G-P_014_001_005&phenotyping_center=WTSI abnormal rib morphology Spns2 homozygote female Early adult X-ray Shape of ribs WTSI EuroPhenome 3.83E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_006_001_017&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_006_001¶meter_stable_id=M-G-P_006_001_017&phenotyping_center=WTSI narrow eye opening Spns2 homozygote female Early adult Eye Morphology Narrow eye opening WTSI IMPC 3.86E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_006_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_006_001&phenotyping_center=WTSI decreased circulating serum albumin level Spns2 homozygote female Early adult Clinical Chemistry Albumin WTSI EuroPhenome 7.48E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_025_001_008&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_025_001¶meter_stable_id=M-G-P_025_001_008&phenotyping_center=WTSI increased thermal nociceptive threshold Spns2 homozygote female Early adult Hot Plate Time of first response WTSI EuroPhenome 8.65E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:4460276&zygosity=homozygote¶meter_stable_id=M-G-P_012_001_001&pipeline_stable_id=M-G-P_001&procedure_stable_id=M-G-P_012_001¶meter_stable_id=M-G-P_012_001_001&phenotyping_center=WTSI abnormal iris morphology Spns2 homozygote female Early adult Eye Morphology Iris/Pupil WTSI IMPC 9.7E-5 //www.mousephenotype.org/data/charts?accession=MGI:2384936&allele_accession_id=MGI:5442804&zygosity=homozygote¶meter_stable_id=IMPC_EYE_010_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_EYE_001¶meter_stable_id=IMPC_EYE_010_001&phenotyping_center=WTSI