Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data Spleen - MPATH pathological process term hyperplasia Cyrib heterozygote male Early adult Histopathology Spleen - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Spleen" Brain - MPATH pathological entity term hydrocephalus Cyrib heterozygote female Early adult Histopathology Brain - MPATH pathological entity term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Brain" Brain - MPATH pathological entity term hydrocephalus Cyrib heterozygote male Early adult Histopathology Brain - MPATH pathological entity term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Brain" preweaning lethality, incomplete penetrance Cyrib homozygote not_considered Early adult Viability Primary Screen Homozygous animals viability TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_VIA_067_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_067_001&phenotyping_center=TCP Testis - MPATH pathological process term hypospermia Cyrib homozygote male Early adult Histopathology Testis - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Testis" male infertility Cyrib homozygote male Early adult Fertility of Homozygous Knock-out Mice Gross Findings Male TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_FER_001_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_FER_001¶meter_stable_id=IMPC_FER_001_001&phenotyping_center=TCP edema Cyrib homozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Edema TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_GEO_064_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_064_001&phenotyping_center=TCP preweaning lethality, incomplete penetrance Cyrib homozygote male Early adult Viability Primary Screen Homozygous males viability TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_VIA_063_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_063_001&phenotyping_center=TCP Brain - MPATH pathological process term developmental dysplasia Cyrib heterozygote female Early adult Histopathology Brain - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Brain" edema Cyrib homozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Edema TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_GEO_064_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_064_001&phenotyping_center=TCP Eye - MPATH pathological process term developmental dysplasia Cyrib homozygote female Early adult Histopathology Eye - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Eye" preweaning lethality, incomplete penetrance Cyrib homozygote female Early adult Viability Primary Screen Homozygous females viability TCP IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_VIA_064_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_064_001&phenotyping_center=TCP Brain - MPATH pathological process term developmental dysplasia Cyrib heterozygote male Early adult Histopathology Brain - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Brain" Spleen - MPATH pathological process term hyperplasia Cyrib homozygote female Early adult Histopathology Spleen - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Spleen" Eye - MPATH pathological process term dysplasia Cyrib heterozygote male Early adult Histopathology Eye - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Eye" Testis - MPATH pathological entity term germ cell defect Cyrib homozygote male Early adult Histopathology Testis - MPATH pathological entity term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Testis" Testis - MPATH pathological process term spermatogenesis defect Cyrib homozygote male Early adult Histopathology Testis - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Testis" Spleen - MPATH pathological process term hyperplasia Cyrib homozygote male Early adult Histopathology Spleen - MPATH pathological process term TCP IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1923520?anatomy="Spleen" abnormal retina morphology Cyrib heterozygote female Early adult Eye Morphology Retina (combined) TCP IMPC 5.8E-10 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_092_002&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_092_002&phenotyping_center=TCP abnormal retina morphology Cyrib heterozygote male Early adult Eye Morphology Retina (combined) TCP IMPC 2.01E-8 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_092_002&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_092_002&phenotyping_center=TCP decreased circulating sodium level Cyrib heterozygote male Early adult Clinical Chemistry Sodium TCP IMPC 5.79E-6 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=heterozygote¶meter_stable_id=IMPC_CBC_001_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_001_001&phenotyping_center=TCP decreased exploration in new environment Cyrib heterozygote female Early adult Combined SHIRPA and Dysmorphology Locomotor activity TCP IMPC 3.04E-5 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=heterozygote¶meter_stable_id=IMPC_CSD_032_001&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_CSD_003¶meter_stable_id=IMPC_CSD_032_001&phenotyping_center=TCP abnormal retina morphology Cyrib homozygote not_considered Early adult Eye Morphology Retina (combined) TCP IMPC 4.8E-5 //www.mousephenotype.org/data/charts?accession=MGI:1923520&allele_accession_id=MGI:5605796&zygosity=homozygote¶meter_stable_id=IMPC_EYE_092_002&pipeline_stable_id=TCP_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_092_002&phenotyping_center=TCP