Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data Liver - MPATH diagnostic term extramedullary hemopoiesis Fbxo7 homozygote female Early adult Histopathology Liver - MPATH diagnostic term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Liver" Spleen - hyperplasia Fbxo7 homozygote female Early adult Histopathology Spleen - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Spleen" Spleen - MPATH diagnostic term extramedullary hemopoiesis Fbxo7 homozygote female Early adult Histopathology Spleen - MPATH diagnostic term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Spleen" Spleen - hyperplasia Fbxo7 homozygote male Early adult Histopathology Spleen - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Spleen" male infertility Fbxo7 homozygote male Early adult Fertility of Homozygous Knock-out Mice Gross Findings Male WTSI IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_FER_001_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_FER_001¶meter_stable_id=IMPC_FER_001_001&phenotyping_center=WTSI Testes - process of degenerative change Fbxo7 homozygote male Early adult Histopathology Testes - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Testes" Eye with optic nerve - atrophy Fbxo7 homozygote male Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Eye with optic nerve" Spleen - MPATH diagnostic term extramedullary hemopoiesis Fbxo7 homozygote male Early adult Histopathology Spleen - MPATH diagnostic term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Spleen" Thymus - hypoplasia Fbxo7 homozygote male Early adult Histopathology Thymus - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Thymus" Bone marrow - hyperplasia Fbxo7 homozygote female Early adult Histopathology Bone marrow - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Bone marrow" Liver - hyperplasia Fbxo7 homozygote female Early adult Histopathology Liver - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Liver" Eye with optic nerve - atrophy Fbxo7 homozygote female Early adult Histopathology Eye with optic nerve - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Eye with optic nerve" Bone marrow - hyperplasia Fbxo7 homozygote male Early adult Histopathology Bone marrow - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Bone marrow" Thymus - hypoplasia Fbxo7 homozygote female Early adult Histopathology Thymus - MPATH process term WTSI IMPC 0.0 //www.mousephenotype.org/data/histopath/MGI:1917004?anatomy="Thymus" increased red blood cell distribution width Fbxo7 homozygote male Early adult Hematology Red blood cell distribution width WTSI IMPC 5.74E-40 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_027_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_027_001&phenotyping_center=WTSI increased red blood cell distribution width Fbxo7 homozygote female Early adult Hematology Red blood cell distribution width WTSI IMPC 4.01E-26 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_027_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_027_001&phenotyping_center=WTSI decreased erythrocyte cell number Fbxo7 homozygote male Early adult Hematology Red blood cell count WTSI IMPC 1.69E-20 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_002_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_002_001&phenotyping_center=WTSI decreased hematocrit Fbxo7 homozygote male Early adult Hematology Hematocrit WTSI IMPC 5.01E-16 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_004_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_004_001&phenotyping_center=WTSI decreased hemoglobin content Fbxo7 homozygote male Early adult Hematology Hemoglobin WTSI IMPC 1.23E-14 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_003_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_003_001&phenotyping_center=WTSI decreased circulating iron level Fbxo7 homozygote female Early adult Clinical Chemistry Iron WTSI IMPC 2.35E-13 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_CBC_011_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_CBC_001¶meter_stable_id=IMPC_CBC_011_001&phenotyping_center=WTSI thrombocytosis Fbxo7 homozygote male Early adult Hematology Platelet count WTSI IMPC 3.8E-12 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_008_001&phenotyping_center=WTSI decreased circulating iron level Fbxo7 homozygote male Early adult Clinical Chemistry Iron WTSI IMPC 1.22E-11 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_CBC_011_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_CBC_001¶meter_stable_id=IMPC_CBC_011_001&phenotyping_center=WTSI increased circulating bilirubin level Fbxo7 homozygote male Early adult Clinical Chemistry Total bilirubin WTSI IMPC 4.26E-10 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_CBC_008_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_CBC_001¶meter_stable_id=IMPC_CBC_008_001&phenotyping_center=WTSI increased mean corpuscular hemoglobin Fbxo7 homozygote male Early adult Hematology Mean corpuscular hemoglobin WTSI IMPC 3.56E-9 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_006_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_006_001&phenotyping_center=WTSI decreased circulating fructosamine level Fbxo7 homozygote female Early adult Clinical Chemistry Fructosamine WTSI IMPC 6.07E-8 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_CBC_020_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_CBC_001¶meter_stable_id=IMPC_CBC_020_001&phenotyping_center=WTSI decreased erythrocyte cell number Fbxo7 homozygote female Early adult Hematology Red blood cell count WTSI IMPC 2.03E-7 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_002_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_002_001&phenotyping_center=WTSI decreased hematocrit Fbxo7 homozygote female Early adult Hematology Hematocrit WTSI IMPC 2.77E-7 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_004_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_004_001&phenotyping_center=WTSI decreased hemoglobin content Fbxo7 homozygote female Early adult Hematology Hemoglobin WTSI IMPC 8.18E-7 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_003_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_003_001&phenotyping_center=WTSI decreased leukocyte cell number Fbxo7 homozygote female Early adult Hematology White blood cell count WTSI IMPC 6.13E-6 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_HEM_001_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_HEM_001¶meter_stable_id=IMPC_HEM_001_001&phenotyping_center=WTSI increased circulating sodium level Fbxo7 homozygote not_considered Early adult Clinical Chemistry Sodium WTSI IMPC 3.52E-5 //www.mousephenotype.org/data/charts?accession=MGI:1917004&allele_accession_id=MGI:4842259&zygosity=homozygote¶meter_stable_id=IMPC_CBC_001_001&pipeline_stable_id=MGP_001&procedure_stable_id=IMPC_CBC_001¶meter_stable_id=IMPC_CBC_001_001&phenotyping_center=WTSI