Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data abnormal lymph node morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Lymph node UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_020_002 spina bifida Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 spina bifida UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_043_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_043_002&phenotyping_center=UC Davis abnormal liver morphology Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Liver UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_010_002 hydrometra Rbm22 heterozygote female Early adult Gross Pathology and Tissue Collection Uterus UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_029_002 preweaning lethality, complete penetrance Rbm22 homozygote female Early adult Viability Primary Screen Homozygous females viability UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=homozygote¶meter_stable_id=IMPC_VIA_064_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_064_001&phenotyping_center=UC Davis abnormal epididymis morphology Rbm22 heterozygote male Early adult Gross Pathology and Tissue Collection Epididymis UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_025_002 abnormal skin morphology Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Skin UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_021_002 enlarged epididymis Rbm22 heterozygote male Early adult Gross Pathology and Tissue Collection Epididymis UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_025_002 preweaning lethality, complete penetrance Rbm22 homozygote male Early adult Viability Primary Screen Homozygous males viability UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=homozygote¶meter_stable_id=IMPC_VIA_063_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_063_001&phenotyping_center=UC Davis abnormal testis morphology Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Testes UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_024_002 preweaning lethality, complete penetrance Rbm22 homozygote not_considered Early adult Viability Primary Screen Viability Outcome JAX IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:5750474&zygosity=homozygote¶meter_stable_id=IMPC_VIA_001_001&pipeline_stable_id=JAX_001&procedure_stable_id=IMPC_VIA_001¶meter_stable_id=IMPC_VIA_001_001&phenotyping_center=JAX abnormal uterus morphology Rbm22 heterozygote female Early adult Gross Pathology and Tissue Collection Uterus UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_029_002 anophthalmia Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Anophthalmia UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_048_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_048_002&phenotyping_center=UC Davis abnormal liver morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Liver UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_010_002 syndactyly Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Syndactyly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_067_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_067_001&phenotyping_center=UC Davis polydactyly Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Polydactyly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_034_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_034_002&phenotyping_center=UC Davis abnormal eye morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Eye with optic nerve UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_002_002 hemorrhage Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Hemorrhage UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_009_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_009_002&phenotyping_center=UC Davis microcephaly Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Microcephaly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_066_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_066_001&phenotyping_center=UC Davis prenatal lethality prior to heart atrial septation Rbm22 homozygote not_considered E15.5 Viability E14.5-E15.5 Secondary Screen Outcome UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=homozygote¶meter_stable_id=IMPC_EVO_001_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_EVO_001¶meter_stable_id=IMPC_EVO_001_001&phenotyping_center=UC Davis preweaning lethality, complete penetrance Rbm22 homozygote not_considered Early adult Viability Primary Screen Homozygous animals viability UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=homozygote¶meter_stable_id=IMPC_VIA_067_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_067_001&phenotyping_center=UC Davis abnormal duodenum morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Small intestine UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_013_002 microphthalmia Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Microphthalmia UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_047_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_047_002&phenotyping_center=UC Davis abnormal heart morphology Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Heart UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_006_002 abnormal lymph node morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Lymph node UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_020_002 enlarged heart Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Heart UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_006_002 anophthalmia Rbm22 heterozygote female Early adult Gross Pathology and Tissue Collection Eye with optic nerve UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_002_002 abnormal ovary morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Ovary UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_028_002 enlarged lymph nodes Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Lymph node UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_020_002 abnormal uterus morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Uterus UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_029_002 small testis Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Testes UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_024_002 abnormal spleen morphology Rbm22 heterozygote male Late adult Gross Pathology and Tissue Collection Spleen UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_016_002 polydactyly Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Polydactyly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_034_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_034_002&phenotyping_center=UC Davis abnormal eye morphology Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Eye with optic nerve UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_002_002 anophthalmia Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Anophthalmia UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_048_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_048_002&phenotyping_center=UC Davis hemorrhage Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Hemorrhage UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_009_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_009_002&phenotyping_center=UC Davis syndactyly Rbm22 heterozygote female E15.5 Gross Morphology Embryo E14.5-E15.5 Syndactyly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_067_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_067_001&phenotyping_center=UC Davis embryonic lethality prior to organogenesis Rbm22 homozygote not_considered E9.5 Viability E9.5 Secondary Screen Outcome UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=homozygote¶meter_stable_id=IMPC_EVL_001_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_EVL_001¶meter_stable_id=IMPC_EVL_001_001&phenotyping_center=UC Davis microphthalmia Rbm22 heterozygote female Late adult Gross Pathology and Tissue Collection Eye with optic nerve UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/UCDLA_PAT_002_002 microcephaly Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Microcephaly UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_066_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_066_001&phenotyping_center=UC Davis spina bifida Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 spina bifida UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_043_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_043_002&phenotyping_center=UC Davis abnormal eye morphology Rbm22 heterozygote female Early adult Gross Pathology and Tissue Collection Eye with optic nerve UC Davis IMPC 0.0 //www.mousephenotype.org/data/grosspath/MGI:1914060/IMPC_PAT_002_002 embryonic lethality prior to organogenesis Rbm22 homozygote not_considered E9.5 Viability E9.5 Secondary Screen Outcome JAX IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:5750474&zygosity=homozygote¶meter_stable_id=IMPC_EVL_001_001&pipeline_stable_id=JAX_001&procedure_stable_id=IMPC_EVL_001¶meter_stable_id=IMPC_EVL_001_001&phenotyping_center=JAX microphthalmia Rbm22 heterozygote male E15.5 Gross Morphology Embryo E14.5-E15.5 Microphthalmia UC Davis IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_GEO_047_002&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_GEO_003¶meter_stable_id=IMPC_GEO_047_002&phenotyping_center=UC Davis abnormal lumbar vertebrae morphology Rbm22 heterozygote not_considered Early adult X-ray Number of lumbar vertebrae UC Davis IMPC 2.9E-12 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_XRY_015_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_XRY_001¶meter_stable_id=IMPC_XRY_015_001&phenotyping_center=UC Davis abnormal sacral vertebrae morphology Rbm22 heterozygote not_considered Early adult X-ray Number of pelvic vertebrae UC Davis IMPC 2.9E-12 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_XRY_016_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_XRY_001¶meter_stable_id=IMPC_XRY_016_001&phenotyping_center=UC Davis increased heart weight Rbm22 heterozygote male Late adult Heart Weight Heart weight UC Davis IMPC 6.13E-9 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=UCDLA_HWT_008_001&pipeline_stable_id=UCDLA_001&procedure_stable_id=UCDLA_HWT_001¶meter_stable_id=UCDLA_HWT_008_001&phenotyping_center=UC Davis increased bone mineral content Rbm22 heterozygote female Early adult Body Composition (DEXA lean/fat) BMC/Body weight UC Davis IMPC 8.91E-8 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_007_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_007_001&phenotyping_center=UC Davis increased heart weight Rbm22 heterozygote male Early adult Heart Weight Heart weight UC Davis IMPC 7.95E-6 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=IMPC_HWT_008_001&pipeline_stable_id=UCD_001&procedure_stable_id=IMPC_HWT_001¶meter_stable_id=IMPC_HWT_008_001&phenotyping_center=UC Davis increased heart weight Rbm22 heterozygote male Early adult Organ Weight Heart weight UC Davis IMPC 8.08E-6 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=UCD_OWT_002_001&pipeline_stable_id=UCD_001&procedure_stable_id=UCD_OWT_001¶meter_stable_id=UCD_OWT_002_001&phenotyping_center=UC Davis decreased startle reflex Rbm22 heterozygote male Early adult Acoustic Startle and Pre-pulse Inhibition (PPI) Response amplitude - S JAX IMPC 1.86E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:5750474&zygosity=heterozygote¶meter_stable_id=IMPC_ACS_006_001&pipeline_stable_id=JAX_001&procedure_stable_id=IMPC_ACS_003¶meter_stable_id=IMPC_ACS_006_001&phenotyping_center=JAX abnormal retina morphology Rbm22 heterozygote not_considered Late adult Eye Morphology Retina (combined) UC Davis IMPC 3.03E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=UCDLA_EYE_092_002&pipeline_stable_id=UCDLA_001&procedure_stable_id=UCDLA_EYE_003¶meter_stable_id=UCDLA_EYE_092_002&phenotyping_center=UC Davis increased bone mineral density Rbm22 heterozygote male Early adult Body Composition (DEXA lean/fat) Bone Mineral Density (excluding skull) JAX IMPC 3.59E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:5750474&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_004_001&pipeline_stable_id=JAX_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_004_001&phenotyping_center=JAX increased mean corpuscular hemoglobin concentration Rbm22 heterozygote female Late adult Hematology Mean cell hemoglobin concentration UC Davis IMPC 4.88E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=UCDLA_HEM_007_001&pipeline_stable_id=UCDLA_001&procedure_stable_id=UCDLA_HEM_002¶meter_stable_id=UCDLA_HEM_007_001&phenotyping_center=UC Davis abnormal vitreous body morphology Rbm22 heterozygote not_considered Late adult Eye Morphology Vitreous UC Davis IMPC 6.23E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:6152623&zygosity=heterozygote¶meter_stable_id=UCDLA_EYE_083_001&pipeline_stable_id=UCDLA_001&procedure_stable_id=UCDLA_EYE_003¶meter_stable_id=UCDLA_EYE_083_001&phenotyping_center=UC Davis increased lean body mass Rbm22 heterozygote not_considered Early adult Body Composition (DEXA lean/fat) Lean/Body weight JAX IMPC 8.4E-5 //www.mousephenotype.org/data/charts?accession=MGI:1914060&allele_accession_id=MGI:5750474&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_008_001&pipeline_stable_id=JAX_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_008_001&phenotyping_center=JAX