Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data preweaning lethality, complete penetrance Timm50 homozygote not_considered Early adult Viability Primary Screen Viability Outcome ICS IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=homozygote¶meter_stable_id=IMPC_VIA_001_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_VIA_001¶meter_stable_id=IMPC_VIA_001_001&phenotyping_center=ICS embryonic lethality prior to tooth bud stage Timm50 homozygote not_considered E12.5 Viability E12.5 Secondary Screen Outcome ICS IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=homozygote¶meter_stable_id=IMPC_EVM_001_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EVM_001¶meter_stable_id=IMPC_EVM_001_001&phenotyping_center=ICS increased circulating alanine transaminase level Timm50 heterozygote male Early adult Clinical Chemistry Alanine aminotransferase ICS IMPC 3.89E-13 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_CBC_013_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_013_001&phenotyping_center=ICS decreased bone mineral content Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Bone Mineral Content (excluding skull) ICS IMPC 5.64E-8 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_005_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_005_001&phenotyping_center=ICS decreased bone mineral content Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) BMC/Body weight ICS IMPC 9.74E-8 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_007_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_007_001&phenotyping_center=ICS increased bone mineral density Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Bone Mineral Density (excluding skull) ICS IMPC 1.05E-7 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_004_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_004_001&phenotyping_center=ICS increased lean body mass Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Lean mass ICS IMPC 8.47E-7 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_003_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_003_001&phenotyping_center=ICS decreased total body fat amount Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Fat mass ICS IMPC 9.44E-7 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_002_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_002_001&phenotyping_center=ICS decreased body length Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Body length ICS IMPC 1.88E-6 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_006_001&phenotyping_center=ICS increased lean body mass Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Lean/Body weight ICS IMPC 6.64E-6 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_008_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_008_001&phenotyping_center=ICS decreased total body fat amount Timm50 heterozygote male Early adult Body Composition (DEXA lean/fat) Fat/Body weight ICS IMPC 8.47E-6 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_DXA_009_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_009_001&phenotyping_center=ICS abnormal retina outer nuclear layer morphology Timm50 heterozygote not_considered Early adult Eye Morphology Right outer nuclear layer ICS IMPC 1.94E-5 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_064_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_064_001&phenotyping_center=ICS decreased total retina thickness Timm50 heterozygote not_considered Early adult Eye Morphology Right total retinal thickness ICS IMPC 6.38E-5 //www.mousephenotype.org/data/charts?accession=MGI:1913775&allele_accession_id=MGI:5548523&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_062_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_062_001&phenotyping_center=ICS