Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data abnormal placenta size Mthfd2 homozygote male E12.5 Gross Morphology Placenta E12.5 Placenta Size BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GPM_004_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GPM_001¶meter_stable_id=IMPC_GPM_004_001&phenotyping_center=BCM abnormal embryo development Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Severely Dysmorphic BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_060_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_060_001&phenotyping_center=BCM preweaning lethality, complete penetrance Mthfd2 homozygote male Early adult Viability Primary Screen Homozygous males viability BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_VIA_063_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_063_001&phenotyping_center=BCM abnormal embryo size Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Embryo Size BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_019_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_019_001&phenotyping_center=BCM abnormal umbilical cord morphology Mthfd2 homozygote female E12.5 Gross Morphology Placenta E12.5 Umbilical cord morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GPM_005_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GPM_001¶meter_stable_id=IMPC_GPM_005_001&phenotyping_center=BCM pale yolk sac Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Pale yolk sac BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_016_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_016_002&phenotyping_center=BCM abnormal craniofacial morphology Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Craniofacial morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_062_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_062_001&phenotyping_center=BCM pallor Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Pallor BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_025_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_025_002&phenotyping_center=BCM abnormal facial morphology Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Facial hypoplasia BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_064_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_064_001&phenotyping_center=BCM abnormal placenta size Mthfd2 homozygote female E12.5 Gross Morphology Placenta E12.5 Placenta Size BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GPM_004_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GPM_001¶meter_stable_id=IMPC_GPM_004_001&phenotyping_center=BCM abnormal eye morphology Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Eye Morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_041_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_041_001&phenotyping_center=BCM abnormal facial morphology Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Facial hypoplasia BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_064_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_064_001&phenotyping_center=BCM pallor Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Pallor BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_025_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_025_002&phenotyping_center=BCM pale liver Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Pale Liver BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_033_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_033_002&phenotyping_center=BCM pale liver Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Pale Liver BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_033_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_033_002&phenotyping_center=BCM prenatal lethality prior to heart atrial septation Mthfd2 homozygote not_considered E15.5 Viability E14.5-E15.5 Secondary Screen Outcome BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_EVO_001_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_EVO_001¶meter_stable_id=IMPC_EVO_001_001&phenotyping_center=BCM embryonic growth retardation Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Delayed embryonic development BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_075_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_075_001&phenotyping_center=BCM abnormal umbilical cord morphology Mthfd2 homozygote male E12.5 Gross Morphology Placenta E12.5 Umbilical cord morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GPM_005_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GPM_001¶meter_stable_id=IMPC_GPM_005_001&phenotyping_center=BCM pale yolk sac Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Pale yolk sac BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_016_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_016_002&phenotyping_center=BCM abnormal cranium morphology Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Head shape BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_047_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_047_001&phenotyping_center=BCM abnormal cranium morphology Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Head shape BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_047_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_047_001&phenotyping_center=BCM abnormal eye morphology Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Eye Morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_041_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_041_001&phenotyping_center=BCM preweaning lethality, incomplete penetrance Mthfd2 homozygote not_considered Early adult Viability Primary Screen Homozygous animals viability BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_VIA_067_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_067_001&phenotyping_center=BCM abnormal embryo development Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Severely Dysmorphic BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_060_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_060_001&phenotyping_center=BCM microphthalmia Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Microphthalmia BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_043_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_043_002&phenotyping_center=BCM abnormal craniofacial morphology Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Craniofacial morphology BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_062_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_062_001&phenotyping_center=BCM abnormal embryo size Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Embryo Size BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_019_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_019_001&phenotyping_center=BCM embryonic growth retardation Mthfd2 homozygote male E12.5 Gross Morphology Embryo E12.5 Delayed embryonic development BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_075_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_075_001&phenotyping_center=BCM microphthalmia Mthfd2 homozygote female E12.5 Gross Morphology Embryo E12.5 Microphthalmia BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_GEM_043_002&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GEM_003¶meter_stable_id=IMPC_GEM_043_002&phenotyping_center=BCM preweaning lethality, incomplete penetrance Mthfd2 homozygote female Early adult Viability Primary Screen Homozygous females viability BCM IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=homozygote¶meter_stable_id=IMPC_VIA_064_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_VIA_002¶meter_stable_id=IMPC_VIA_064_001&phenotyping_center=BCM increased cornea thickness Mthfd2 heterozygote female Early adult Eye Morphology Right corneal thickness BCM IMPC 4.2E-7 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_060_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_060_001&phenotyping_center=BCM increased heart left ventricle size Mthfd2 heterozygote not_considered Early adult Echo LVAWd BCM IMPC 5.75E-6 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=heterozygote¶meter_stable_id=IMPC_ECH_007_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_ECH_001¶meter_stable_id=IMPC_ECH_007_001&phenotyping_center=BCM thick ventricular wall Mthfd2 heterozygote not_considered Early adult Echo LVAWs BCM IMPC 9.77E-6 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=heterozygote¶meter_stable_id=IMPC_ECH_010_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_ECH_001¶meter_stable_id=IMPC_ECH_010_001&phenotyping_center=BCM increased heart rate Mthfd2 heterozygote not_considered Early adult Echo HR BCM IMPC 2.63E-5 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=heterozygote¶meter_stable_id=IMPC_ECH_013_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_ECH_001¶meter_stable_id=IMPC_ECH_013_001&phenotyping_center=BCM increased grip strength Mthfd2 heterozygote female Early adult Grip Strength Forelimb grip strength normalised against body weight BCM IMPC 4.86E-5 //www.mousephenotype.org/data/charts?accession=MGI:1338850&allele_accession_id=MGI:6120705&zygosity=heterozygote¶meter_stable_id=IMPC_GRS_010_001&pipeline_stable_id=BCM_001&procedure_stable_id=IMPC_GRS_001¶meter_stable_id=IMPC_GRS_010_001&phenotyping_center=BCM