Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data preweaning lethality, complete penetrance Dyrk1b homozygote not_considered Early adult Viability Primary Screen Viability Outcome ICS IMPC 0.0 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=homozygote¶meter_stable_id=IMPC_VIA_001_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_VIA_001¶meter_stable_id=IMPC_VIA_001_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote male Late adult Eye Morphology Right total retinal thickness ICS IMPC 6.85E-15 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_062_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_062_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote male Late adult Eye Morphology Left total retinal thickness ICS IMPC 7.66E-15 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_068_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_068_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote female Late adult Eye Morphology Left total retinal thickness ICS IMPC 6.94E-13 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_068_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_068_001&phenotyping_center=ICS abnormal retina inner nuclear layer morphology Dyrk1b heterozygote female Late adult Eye Morphology Left inner nuclear layer ICS IMPC 6.5E-12 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_069_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_069_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote female Late adult Eye Morphology Right total retinal thickness ICS IMPC 3.82E-11 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_062_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_062_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote female Early adult Eye Morphology Right total retinal thickness ICS IMPC 3.3E-10 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_062_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_062_001&phenotyping_center=ICS abnormal retina inner nuclear layer morphology Dyrk1b heterozygote female Late adult Eye Morphology Right inner nuclear layer ICS IMPC 1.04E-9 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_EYE_063_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_EYE_003¶meter_stable_id=ICSLA_EYE_063_001&phenotyping_center=ICS abnormal retina inner nuclear layer morphology Dyrk1b heterozygote female Early adult Eye Morphology Right inner nuclear layer ICS IMPC 1.21E-9 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_063_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_063_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote male Early adult Eye Morphology Right total retinal thickness ICS IMPC 1.39E-9 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_062_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_062_001&phenotyping_center=ICS abnormal retina inner nuclear layer morphology Dyrk1b heterozygote female Early adult Eye Morphology Left inner nuclear layer ICS IMPC 6.62E-8 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_069_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_069_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote female Early adult Eye Morphology Left total retinal thickness ICS IMPC 8.35E-8 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_068_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_068_001&phenotyping_center=ICS abnormal auditory brainstem response Dyrk1b heterozygote not_considered Early adult Auditory Brain Stem Response 30kHz-evoked ABR Threshold ICS IMPC 8.84E-8 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_ABR_012_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ABR_002¶meter_stable_id=IMPC_ABR_012_001&phenotyping_center=ICS decreased total retina thickness Dyrk1b heterozygote male Early adult Eye Morphology Left total retinal thickness ICS IMPC 1.5E-7 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_068_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_068_001&phenotyping_center=ICS decreased large unstained cell number Dyrk1b heterozygote male Early adult Hematology Large Unstained Cell (LUC) differential count ICS IMPC 7.55E-7 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_HEM_040_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HEM_002¶meter_stable_id=IMPC_HEM_040_001&phenotyping_center=ICS decreased large unstained cell number Dyrk1b heterozygote female Early adult Hematology Large Unstained Cell (LUC) differential count ICS IMPC 9.05E-7 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_HEM_040_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HEM_002¶meter_stable_id=IMPC_HEM_040_001&phenotyping_center=ICS decreased large unstained cell number Dyrk1b heterozygote not_considered Early adult Hematology Large Unstained Cell (LUC) count ICS IMPC 1.2E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_HEM_039_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HEM_002¶meter_stable_id=IMPC_HEM_039_001&phenotyping_center=ICS decreased locomotor activity Dyrk1b heterozygote female Late adult Open Field Number of center entries ICS IMPC 1.75E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_OFD_019_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_OFD_001¶meter_stable_id=ICSLA_OFD_019_001&phenotyping_center=ICS increased prepulse inhibition Dyrk1b heterozygote not_considered Early adult Acoustic Startle and Pre-pulse Inhibition (PPI) % Pre-pulse inhibition - PPI2 ICS IMPC 2.14E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_ACS_034_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ACS_003¶meter_stable_id=IMPC_ACS_034_001&phenotyping_center=ICS decreased blood urea nitrogen level Dyrk1b heterozygote not_considered Early adult Clinical Chemistry Urea (Blood Urea Nitrogen - BUN) ICS IMPC 2.88E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_CBC_004_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_004_001&phenotyping_center=ICS abnormal retina morphology Dyrk1b heterozygote male Early adult Eye Morphology Retina (combined) ICS IMPC 3.25E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_092_002&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_092_002&phenotyping_center=ICS decreased locomotor activity Dyrk1b heterozygote not_considered Late adult Open Field Center distance travelled ICS IMPC 3.27E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_OFD_014_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_OFD_001¶meter_stable_id=ICSLA_OFD_014_001&phenotyping_center=ICS abnormal retina morphology Dyrk1b heterozygote female Early adult Eye Morphology Retina (combined) ICS IMPC 4.11E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_EYE_092_002&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_092_002&phenotyping_center=ICS decreased bone mineral density Dyrk1b heterozygote male Late adult Body Composition (DEXA lean/fat) Bone Mineral Density (excluding skull) ICS IMPC 4.14E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=ICSLA_DXA_004_001&pipeline_stable_id=ICSLA_001&procedure_stable_id=ICSLA_DXA_001¶meter_stable_id=ICSLA_DXA_004_001&phenotyping_center=ICS decreased startle reflex Dyrk1b heterozygote male Early adult Acoustic Startle and Pre-pulse Inhibition (PPI) Response amplitude - S ICS IMPC 6.32E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_ACS_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ACS_003¶meter_stable_id=IMPC_ACS_006_001&phenotyping_center=ICS decreased lymphocyte cell number Dyrk1b heterozygote not_considered Early adult Hematology Lymphocyte cell count ICS IMPC 9.12E-5 //www.mousephenotype.org/data/charts?accession=MGI:1330302&allele_accession_id=MGI:5548430&zygosity=heterozygote¶meter_stable_id=IMPC_HEM_032_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HEM_002¶meter_stable_id=IMPC_HEM_032_001&phenotyping_center=ICS