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Gene: Mir124a-2 MGI:3618700

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Gene Summary

Name:
microRNA 124a-2
Synonyms:
mir-124a-2,  mmu-mir-124-2,  mmu-mir-124a-2,  Mirn124a-2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Mir124a-2tm1b(mirKO)Wtsi HOM   Early adult 0.00
decreased locomotor activity Mir124a-2tm1b(mirKO)Wtsi HET   Early adult 3.11×10-05
abnormal contextual conditioning behavior Mir124a-2tm1b(mirKO)Wtsi HET   Early adult 5.88×10-06
decreased total retina thickness Mir124a-2tm1b(mirKO)Wtsi HET Early adult 4.85×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Mir124a-2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mir124a-2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mir124a-2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mir124a-2.

No publications found that use IMPC mice or data for Mir124a-2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mir124a-2tm1(mirKO)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Mir124a-2tm1b(mirKO)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Mir124a-2tm1d(mirKO)Wtsi Deletion allele (post-Flp and Cre with no reporter) Mice

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