IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|decreased total retina thickness||Mir124a-2tm1b(mirKO)Wtsi||HET||Early adult||4.85×10-05|
|preweaning lethality, complete penetrance||Mir124a-2tm1b(mirKO)Wtsi||HOM||Early adult||0.00|
|abnormal contextual conditioning behavior||Mir124a-2tm1b(mirKO)Wtsi||HET||Early adult||5.88×10-06|
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Mir124a-2 by phenotypic similarity.
|Retinal Dysplasia, Primary||
||Retinal dysplasia, Falciform retinal fold||OMIM:312550|
|Stargardt Disease 1||
||Retinitis pigmentosa inversa, Macular degeneration, Bull's eye maculopathy||OMIM:248200|
|Exudative Vitreoretinopathy 7||
||Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal degeneration, Retinal detachment||OMIM:617572|
|Exudative Vitreoretinopathy 3||
||Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal exudate, Retinal detachment||OMIM:605750|
|Retinoschisis 1, X-Linked, Juvenile||
||Retinal pigment epithelial atrophy, Vitreous hemorrhage, Retinal atrophy, Retinal degeneration, M...||OMIM:312700|
|Reese Retinal Dysplasia||
||Retinal dysplasia, Remnants of the hyaloid vascular system||OMIM:266400|
|Coloboma Of Optic Nerve||
||Retinal detachment, Optic disc coloboma||OMIM:120430|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
|MGI Allele||Allele Type||Produced|
|Mir124a-2tm1(mirKO)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Mir124a-2tm1b(mirKO)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Mice|
|Mir124a-2tm1d(mirKO)Wtsi||Deletion allele (post-Flp and Cre with no reporter)||Mice|
Get highlights of the most important data releases, news and events, delivered straight to your email inboxSubscribe to newsletter