Cardiovascular System

This page introduces cardiovascular related phenotypes present in mouse lines produced by the IMPC. The cardiovascular system refers to the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan.


Current Total Number of Genes Tested: 9234

Approach

In order to identify the function of genes, the consortium uses a series of standardised protocols as described in IMPReSS (International Mouse Phenotyping Resource of Standardised Screens).

Heart and vascular function/physiology are measured through several procedures like echocardiography and electrocardiogram and non-invasive blood pressure. Cardiovascular system morphology is assessed through macroscopic and microscopic measurements, like heart weight, gross pathology and gross morphology in both embryo and adult animals. A complete list of protocols and related phenotypes are presented in the table below. Links to impress are provided for more details on the procedure.

Procedures that can lead to relevant phenotype associations

Young Adult:

Embryo:

Phenotypes distribution

This graph shows genes with a significant effect on at least one cardiovascular system phenotype.

The following diagram represents the various biological system phenotypes associations for genes linked to cardiovascular system phenotypes. The line thickness is correlated with the strength of the association.

Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.

Cardiovascular system IKMC/IMPC related publications

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