Cardiovascular System

This page introduces cardiovascular related phenotypes present in mouse lines produced by the IMPC. The cardiovascular system refers to the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan.

Current Total Number of Genes Tested: 5684

Approach

In order to identify the function of genes, the consortium uses a series of standardised protocols as described in IMPReSS (International Mouse Phenotyping Resource of Standardised Screens).

Heart and vascular function/physiology are measured through several procedures like echocardiography and electrocardiogram and non-invasive blood pressure. Cardiovascular system morphology is assessed through macroscopic and microscopic measurements, like heart weight, gross pathology and gross morphology in both embryo and adult animals. A complete list of protocols and related phenotypes are presented in the table below. Links to impress are provided for more details on the procedure.

Procedures that can lead to relevant phenotype associations

Young Adult:

Embryo:

Phenotypes distribution

This graph shows genes with a significant effect on at least one cardiovascular system phenotype.

The following diagram represents the various biological system phenotypes associations for genes linked to cardiovascular system phenotypes. The line thickness is correlated with the strength of the association.

Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.

Gene KO effect comparator for cardiovascular system continuous parameters

The parallel coordinates viewer allows to compare variation across parameters for a particular mouse line, as well as across lines, for continous parameters.

The values displayed are the genotype effect. The measurement values are corrected to account for batch effects to represent the true genotype effect, thus allowing a side-by-side comparison.

Use this interactive graph and table:

  • Drag your mouse pointer on any parameter axis to select a region of interest and highlight the relevant mouse lines in the chart. The associated gene/s will be automatically filtered for in the gene table below.
  • You can click on a line to highlight it. The associated gene will be automatically filtered for in the gene table below.
  • You can filter by procedure. You can learn more about the parameters by searching for them in IMPReSS
  • Click on any row in the gene table to highlight the corresponding values in the graph above. Clicking on the gene name will open the associated gene page.
  • When you select a gene row, the parameter name in the graph will change to bold if genotype is significant.
  • Reload page to return to the default view.

cardiovascular system IKMC/IMPC related publications

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