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The Phenotyping Work group consists of 5 to 6 experts from each participating member of the IMPC, along with additional external experts reflecting phenotyping expertise from the wider mouse, clinical, biotech and pharmaceutical communities. The Phenotyping Workgroup will advise the IMPC Steering Committee on the core phenotyping platforms that should be implemented as part of an IMPC primary phenotyping pipeline, taking account of the strategic needs for mouse models and the requirements of the wider biomedical, clinical, biotech and pharmaceutical communities. The work group will consider the development and inclusion of new phenotyping platforms, the timing of tests, test orders and cohort size. In addition they will advise on the statistical issues associated with the use of control cohorts, the identification of phenotypes and provide guidance on the likely costs of a core phenotyping pipeline.
Phenotype Work Group Report
A report from the IMPC Phenotyping workgroup is now available to download, and we welcome your comments and input. The report concludes by presenting a draft IMPC phenotype pipeline. However, note that the draft pipeline is at this stage an amalgam of the key primary tests that following the discussions of the Phenotype Workgroup merited serious consideration for incorporation into a final IMPC pipeline. The draft presented in Fig. 1 and 2 is a starting point for further discussion and design of a final agreed pipeline. The establishment of the final IMPC pipeline will require additional review and iterations, particularly to take account of test density, inter-test perturbations and the minimisation of these effects.
Adult Pipeline information can be found in IMPReSS.