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IMPC Lethal Lines and Sample OPT/MicroCT images

This page temporarily provides Viability information for IMPC lines until the data can be incorporated into the portal. This page is aimed at those who have requested this information for planning a submission to PAR-13-231. For each center currently generating mice, each line is listed that has been identified either as lethal (no HOM pups at ~P14) or subviable (<12.5% Hom pups at ~P14), along with when the last update was received.

The Europhenome calls have been updated to take some lines out that were non-single knockout mouse lines.

In addition, Mark Henkelman (MICe) has kindly provided a set of stock images for both OPT and MicroCT so that researchers can get a feel for the type of data we will be collecting for IMPC embryonic lethal pipeline.

MICe Embryo Images.pptx

List last updated 02/06/14 with data currently in the live database: 556 lines, 119 lethal, 52 subviable, 384 viable




Center Gene Symbol Description
BCM Ascc2 Lethal
BCM Tmem132a Lethal
BCM Cdipt Lethal
BCM Tfeb Lethal
BCM Mapkap1 Lethal
BCM Alg10b Lethal
GMC Dpp9 Lethal
GMC Pcx Lethal
GMC Dbn1 Lethal
GMC Rest Lethal
GMC Dnajc17 Lethal
GMC Mybbp1a Lethal
GMC Mocs2 Lethal
GMC Ndufa8 Lethal
GMC Ivd Lethal
Harwell Slc39a8 Lethal
Harwell Kdm8 Lethal
Harwell Ric8b Lethal
Harwell Cbx2 Lethal
Harwell Furin Lethal
Harwell Xbp1 Lethal
Harwell Rsbn1 Lethal
Harwell Eaf1 Lethal
Harwell Slc40a1 Lethal
Harwell Tango6 Lethal
Harwell Atg3 Lethal
Harwell BC055324 Lethal
Harwell Bag3 Lethal
Harwell Frs2 Lethal
Harwell Lifr Lethal
Harwell Fgf10 Lethal
Harwell F10 Lethal
Harwell Klhdc2 Lethal
Harwell Usp22 Lethal
Harwell Nxn Lethal
Harwell Gosr2 Lethal
Harwell Mllt3 Lethal
Harwell Klf7 Lethal
Harwell Scnn1b Lethal
Harwell Map3k7 Lethal
Harwell Tulp3 Lethal
Harwell Scn4a Lethal
Harwell Otub1 Lethal
Harwell Mtch2 Lethal
ICS Ino80 Lethal
ICS Timm50 Lethal
ICS Cdk8 Lethal
ICS Pigu Lethal
ICS Pax4 Lethal
ICS Nae1 Lethal
ICS Prdm10 Lethal
ICS Atp6v1d Lethal
ICS Yipf5 Lethal
ICS Cdc26 Lethal
ICS Chrna1 Lethal
ICS Kctd15 Lethal
ICS Synpo2 Lethal
ICS Ppp6c Lethal
JAX Wars2 Lethal
JAX Zmiz2 Lethal
JAX Strn3 Lethal
JAX Nsf Lethal
JAX Cenpo Lethal
JAX Atr Lethal
JAX Sptssa Lethal
JAX Palb2 Lethal
JAX Cdc20 Lethal
JAX Adar Lethal
JAX Rpa1 Lethal
JAX Dnajc9 Lethal
JAX Nemf Lethal
JAX Prep Lethal
JAX Med11 Lethal
JAX Atrip Lethal
JAX Pcsk5 Lethal
JAX Hspa5 Lethal
JAX Dhx30 Lethal
JAX Cr1l Lethal
JAX Rgp1 Lethal
JAX Rint1 Lethal
JAX Pigh Lethal
JAX Lrp1 Lethal
JAX Cox7c Lethal
JAX Dmap1 Lethal
JAX Cacna1s Lethal
JAX Dbn1 Lethal
JAX Arid3a Lethal
JAX Exosc8 Lethal
JAX Wdr12 Lethal
JAX Cinp Lethal
JAX Polr2h Lethal
NorCOMM2 Dhfr Lethal
NorCOMM2 Gnpda1 Lethal
NorCOMM2 Atp5b Lethal
NorCOMM2 Wee1 Lethal
NorCOMM2 Cox19 Lethal
NorCOMM2 Gart Lethal
NorCOMM2 Pik3c2a Lethal
NorCOMM2 Atp6v1d Lethal
NorCOMM2 Myo18a Lethal
NorCOMM2 Atp6v1b2 Lethal
NorCOMM2 Spop Lethal
NorCOMM2 Atp6v0a1 Lethal
NorCOMM2 Chd1 Lethal
NorCOMM2 Yars Lethal
NorCOMM2 Coa5 Lethal
NorCOMM2 Lmbrd1 Lethal
DTCC Clcf1 Lethal
DTCC Tbx4 Lethal
DTCC Pex26 Lethal
DTCC Ptma Lethal
DTCC Ino80b Lethal
DTCC Exoc8 Lethal
DTCC Slc39a7 Lethal
DTCC Med28 Lethal
DTCC Uts2b Lethal
DTCC Flii Lethal
DTCC Nxn Lethal
BCM Fbxw9 Subviable
GMC Car4 Subviable
GMC Rora Subviable
GMC Lsm1 Subviable
GMC Abcb11 Subviable
GMC Cap2 Subviable
Harwell Sirt1 Subviable
Harwell Hipk2 Subviable
Harwell Smoc1 Subviable
Harwell Dbn1 Subviable
Harwell Hace1 Subviable
Harwell Pdpn Subviable
Harwell Rhbdl3 Subviable
Harwell Usp3 Subviable
Harwell Agl Subviable
ICS Klhl29 Subviable
ICS Setbp1 Subviable
ICS Pcsk1 Subviable
ICS Dnal4 Subviable
ICS 5330417C22Rik Subviable
ICS Ncs1 Subviable
JAX Pax7 Subviable
JAX Rdx Subviable
JAX Hsf1 Subviable
JAX Dnaja1 Subviable
JAX Ghr Subviable
JAX Bach1 Subviable
JAX Jam3 Subviable
JAX Rnf10 Subviable
JAX Cwc27 Subviable
JAX Dnajb12 Subviable
JAX Dnmt3a Subviable
JAX Slc1a3 Subviable
JAX Ube2o Subviable
JAX Itga8 Subviable
JAX Prkab1 Subviable
JAX Dnajc16 Subviable
JAX Htr1b Subviable
NorCOMM2 Ggnbp2 Subviable
NorCOMM2 Zfp260 Subviable
DTCC Rnf10 Subviable
DTCC Tox3 Subviable
DTCC Dbn1 Subviable
DTCC Ampd1 Subviable
DTCC Zhx3 Subviable
DTCC Abi3bp Subviable
DTCC Lypd3 Subviable
DTCC Fnbp1l Subviable
DTCC Acvr2a Subviable
DTCC S100a6 Subviable
DTCC Fan1 Subviable
DTCC Unc13b Subviable
Europhenome 2310067B10Rik Lethal
Europhenome Adar Lethal
Europhenome Arpc4 Lethal
Europhenome Ascc3 Lethal
Europhenome Asxl1 Lethal
Europhenome B9d1 Lethal
Europhenome BC055324 Lethal
Europhenome Bloc1s1 Lethal
Europhenome Brd8 Lethal
Europhenome C1qbp Lethal
Europhenome Cdh1 Lethal
Europhenome Cds2 Lethal
Europhenome Chd7 Lethal
Europhenome Cit Lethal
Europhenome Cntfr Lethal
Europhenome Col5a1 Lethal
Europhenome Cops4 Lethal
Europhenome Cpeb4 Lethal
Europhenome Crtc1 Lethal
Europhenome Cul7 Lethal
Europhenome Ddx27 Lethal
Europhenome Ddx52 Lethal
Europhenome Dhcr24 Lethal
Europhenome Dnajc17 Lethal
Europhenome Dot1l Lethal
Europhenome Elk4 Lethal
Europhenome Epc2 Lethal
Europhenome Ercc2 Lethal
Europhenome Fam110b Lethal
Europhenome Fpgs Lethal
Europhenome Gap43 Lethal
Europhenome Gar1 Lethal
Europhenome Gbe1 Lethal
Europhenome Gmnn Lethal
Europhenome Grhl3 Lethal
Europhenome Gsta3 Lethal
Europhenome Hcn4 Lethal
Europhenome Hdac1 Lethal
Europhenome Hdac3 Lethal
Europhenome Hgs Lethal
Europhenome Hspb11 Lethal
Europhenome Ift122 Lethal
Europhenome Ift20 Lethal
Europhenome Ikbkap Lethal
Europhenome Impad1 Lethal
Europhenome Ino80e Lethal
Europhenome Ints12 Lethal
Europhenome Jmjd5 Lethal
Europhenome Jmjd6 Lethal
Europhenome Ldha Lethal
Europhenome Mapk1 Lethal
Europhenome Mecr Lethal
Europhenome Med18 Lethal
Europhenome Mis18bp1 Lethal
Europhenome Mks1 Lethal
Europhenome Mpi Lethal
Europhenome Mrpl10 Lethal
Europhenome Mrpl54 Lethal
Europhenome Mrps35 Lethal
Europhenome Mthfd1l Lethal
Europhenome Myh9 Lethal
Europhenome Ncaph2 Lethal
Europhenome Ndufs3 Lethal
Europhenome Nf1 Lethal
Europhenome Nfkbid Lethal
Europhenome Pa2g4 Lethal
Europhenome Pex16 Lethal
Europhenome Pik3c3 Lethal
Europhenome Pnpt1 Lethal
Europhenome Prmt1 Lethal
Europhenome Prmt5 Lethal
Europhenome Rars2 Lethal
Europhenome Rhot1 Lethal
Europhenome Rnaseh2b Lethal
Europhenome Rnf7 Lethal
Europhenome Ruvbl1 Lethal
Europhenome Secisbp2 Lethal
Europhenome Sgol1 Lethal
Europhenome Slc25a38 Lethal
Europhenome Snf8 Lethal
Europhenome Snip1 Lethal
Europhenome Spns1 Lethal
Europhenome Sympk Lethal
Europhenome Tcf7l2 Lethal
Europhenome Tmem167 Lethal
Europhenome Tpm1 Lethal
Europhenome Trim45 Lethal
Europhenome Ube2b Lethal
Europhenome Uhrf1 Lethal
Europhenome Wbscr16 Lethal
Europhenome Xbp1 Lethal
Europhenome Zranb2 Lethal
Europhenome Adam17 Subviable
Europhenome Baz1b Subviable
Europhenome Brd7 Subviable
Europhenome Brpf3 Subviable
Europhenome Csrp2bp Subviable
Europhenome Drg2 Subviable
Europhenome E430025E21Rik Subviable
Europhenome Epc1 Subviable
Europhenome Fabp3 Subviable
Europhenome Frmd5 Subviable
Europhenome Ikbkb Subviable
Europhenome Jarid2 Subviable
Europhenome Limk2 Subviable
Europhenome Mapre3 Subviable
Europhenome Mbtd1 Subviable
Europhenome Mmp11 Subviable
Europhenome Mtmr4 Subviable
Europhenome Mysm1 Subviable
Europhenome Ngfr Subviable
Europhenome Nsun2 Subviable
Europhenome Parl Subviable
Europhenome Pik3c3 Subviable
Europhenome Pla2g10 Subviable
Europhenome Rc3h1 Subviable
Europhenome Rc3h2 Subviable
Europhenome Slx4 Subviable
Europhenome Srsf4 Subviable
Europhenome Stx8 Subviable
Europhenome Trpc4ap Subviable
Europhenome Ttll1 Subviable
Europhenome Uros Subviable
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