IMPC Lethal Lines

This page temporarily provides Viability information for IMPC lines until the data can be incorporated into the portal. This page is aimed at those who have requested this information for planning a submission to PAR-13-231. For each center currently generating mice, each line is listed that has been identified either as lethal (no HOM pups at ~P14) or subviable (<12.5% Hom pups at ~P14), along with when the last update was received. Some centers have provided equivalent viability information for the E12.5 screen.

This list is very much a work in progress and new lines will be added at least once a month as centers identify new lethal lines. Some of these strains are already very well characterised and are included on this list for completeness.

The Europhenome calls have been updated to take some lines out that were non-single knockout mouse lines.

List last updated 13/09/13 with updates from ICS, DTCC, TCP

Center Gene Description Date Updated

JAX

Slc1a3

Subviable

20/08/13

JAX

Resp18

Subviable

-

JAX

Hsf1

Lethal

-

BCM

Akt1s1

Lethal

06/08/13

BCM

Alg10b

Lethal & Lethal E12.5

-

BCM

Mogs

Lethal & Lethal E12.5

-

BCM

Nxn

Lethal & Perinatal lethal tm1a

-

BCM

Mapkap1

Lethal

-

DTCC

Satb2

Lethal & Perinatal Lethal

5/9/2013

DTCC

Tox3

Subviable

-

DTCC

Skida1

Subviable

-

DTCC

Rsad1

Subviable

-

DTCC

Ampd1

Subviable & Perinatal Lethal

-

DTCC

Gtpbp2

Subviable

-

DTCC

Kctd15

Lethal & Perinatal Lethal

-

DTCC

Rnf20

Lethal

-

DTCC

Ddost

Lethal & Lethal at E12.5 & Lethal at E9.5

-

DTCC

Slc52a2

Lethal & Subviable at E12.5 & Viable at E9.5

-

DTCC

Acvr1b

Lethal & Lethal at E12.5 & Lethal at E9.5

-

DTCC

Cox4i1

Lethal

-

DTCC

Fus

Lethal & Viable at E12.5

-

NorCOMM2

Spop

Lethal & Viable at E12.5

5/9/2013

NorCOMM2

Atp6v1b2

Lethal

-

NorCOMM2

Coa5

Lethal

-

NorCOMM2

Gnpda1

Lethal

-

WTSI

Smpd4

Subviable

19/08/13

WTSI

Dbn1

Lethal

-

WTSI

Ap2a2

Subviable

-

WTSI

Exoc3l2

Lethal

-

WTSI

Rundc1

Lethal

-

WTSI

Zkscan17

Lethal

-

WTSI

Mybphl

Lethal

-

WTSI

Cpsf3

Lethal

-

WTSI

Mkrn2

Subviable

-

WTSI

Zfp616

Subviable

-

Harwell

JMJD5

Lethal

29/08/13

Harwell

SCL40A1

Lethal

-

Harwell

RSBN1

Lethal

-

Harwell

FURIN

Lethal

-

Harwell

XBP1

Lethal

-

Harwell

CBX2

Lethal

-

Harwell

HIPK2

Lethal

-

Harwell

EAF1

Lethal

-

Harwell

RHBDL3

Subviable

-

Harwell

AGL

Subviable

-

GMC

Mybbp1a

Lethal

09/08/13

GMC

Mocs2

Lethal

-

GMC

Dpp9

Lethal

-

ICS

Klhl29

Subviable

04/09/13

ICS

Kctd15

Lethal

-

ICS

Nol8

Subviable

-

ICS

Ino80

Subviable

-

ICS

Timm50

Lethal

-

ICS

Ppp6c

Lethal

-

ICS

Atp6v1d

Lethal

-

ICS

Prdm10

Lethal

-

ICS

Nae1

Lethal

-

ICS

Yipf5

Lethal

-

ICS

Tmem63b

Lethal

-

ICS

Chrna1

Lethal

-

ICS

Pigu

Lethal

-

ICS

Otub1

Lethal

-

ICS

Cdc26

Lethal

-

Europhenome 2310067B10Rik Lethal

29/08/13

Europhenome Adar Lethal

-

Europhenome Arpc4 Lethal

-

Europhenome Ascc3 Lethal

-

Europhenome Asxl1 Lethal

-

Europhenome B9d1 Lethal

-

Europhenome BC055324 Lethal

-

Europhenome Bloc1s1 Lethal

-

Europhenome Brd8 Lethal

-

Europhenome C1qbp Lethal

-

Europhenome Cdh1 Lethal

-

Europhenome Cds2 Lethal

-

Europhenome Chd7 Lethal

-

Europhenome Cit Lethal

-

Europhenome Cntfr Lethal

-

Europhenome Col5a1 Lethal

-

Europhenome Cops4 Lethal

-

Europhenome Cpeb4 Lethal

-

Europhenome Crtc1 Lethal

-

Europhenome Cul7 Lethal

-

Europhenome Ddx27 Lethal

-

Europhenome Ddx52 Lethal

-

Europhenome Dhcr24 Lethal

-

Europhenome Dnajc17 Lethal

-

Europhenome Dot1l Lethal

-

Europhenome Elk4 Lethal

-

Europhenome Epc2 Lethal

-

Europhenome Ercc2 Lethal

-

Europhenome Fam110b Lethal

-

Europhenome Fpgs Lethal

-

Europhenome Gap43 Lethal

-

Europhenome Gar1 Lethal

-

Europhenome Gbe1 Lethal

-

Europhenome Gmnn Lethal

-

Europhenome Grhl3 Lethal

-

Europhenome Gsta3 Lethal

-

Europhenome Hcn4 Lethal

-

Europhenome Hdac1 Lethal

-

Europhenome Hdac3 Lethal

-

Europhenome Hgs Lethal

-

Europhenome Hspb11 Lethal

-

Europhenome Ift122 Lethal

-

Europhenome Ift20 Lethal

-

Europhenome Ikbkap Lethal

-

Europhenome Impad1 Lethal

-

Europhenome Ino80e Lethal

-

Europhenome Ints12 Lethal

-

Europhenome Jmjd5 Lethal

-

Europhenome Jmjd6 Lethal

-

Europhenome Ldha Lethal

-

Europhenome Mapk1 Lethal

-

Europhenome Mecr Lethal

-

Europhenome Med18 Lethal

-

Europhenome Mis18bp1 Lethal

-

Europhenome Mks1 Lethal

-

Europhenome Mpi Lethal

-

Europhenome Mrpl10 Lethal

-

Europhenome Mrpl54 Lethal

-

Europhenome Mrps35 Lethal

-

Europhenome Mthfd1l Lethal

-

Europhenome Myh9 Lethal

-

Europhenome Ncaph2 Lethal

-

Europhenome Ndufs3 Lethal

-

Europhenome Nf1 Lethal

-

Europhenome Nfkbid Lethal

-

Europhenome Pa2g4 Lethal

-

Europhenome Pex16 Lethal

-

Europhenome Pik3c3 Lethal

-

Europhenome Pnpt1 Lethal

-

Europhenome Prmt1 Lethal

-

Europhenome Prmt5 Lethal

-

Europhenome Rars2 Lethal

-

Europhenome Rhot1 Lethal

-

Europhenome Rnaseh2b Lethal

-

Europhenome Rnf7 Lethal

-

Europhenome Ruvbl1 Lethal

-

Europhenome Secisbp2 Lethal

-

Europhenome Sgol1 Lethal

-

Europhenome Slc25a38 Lethal

-

Europhenome Snf8 Lethal

-

Europhenome Snip1 Lethal

-

Europhenome Spns1 Lethal

-

Europhenome Sympk Lethal

-

Europhenome Tcf7l2 Lethal

-

Europhenome Tmem167 Lethal

-

Europhenome Tpm1 Lethal

-

Europhenome Trim45 Lethal

-

Europhenome Ube2b Lethal

-

Europhenome Uhrf1 Lethal

-

Europhenome Wbscr16 Lethal

-

Europhenome Xbp1 Lethal

-

Europhenome Zranb2 Lethal

-

Europhenome Adam17 Subviable

-

Europhenome Baz1b Subviable

-

Europhenome Brd7 Subviable

-

Europhenome Brpf3 Subviable

-

Europhenome Csrp2bp Subviable

-

Europhenome Drg2 Subviable

-

Europhenome E430025E21Rik Subviable

-

Europhenome Epc1 Subviable

-

Europhenome Fabp3 Subviable

-

Europhenome Frmd5 Subviable

-

Europhenome Ikbkb Subviable

-

Europhenome Jarid2 Subviable

-

Europhenome Limk2 Subviable

-

Europhenome Mapre3 Subviable

-

Europhenome Mbtd1 Subviable

-

Europhenome Mmp11 Subviable

-

Europhenome Mtmr4 Subviable

-

Europhenome Mysm1 Subviable

-

Europhenome Ngfr Subviable

-

Europhenome Nsun2 Subviable

-

Europhenome Parl Subviable

-

Europhenome Pik3c3 Subviable

-

Europhenome Pla2g10 Subviable

-

Europhenome Rc3h1 Subviable

-

Europhenome Rc3h2 Subviable

-

Europhenome Slx4 Subviable

-

Europhenome Srsf4 Subviable

-

Europhenome Stx8 Subviable

-

Europhenome Trpc4ap Subviable

-

Europhenome Ttll1 Subviable

-

Europhenome Uros Subviable

-