Agap1 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | International Mouse Phenotyping Consortium

Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Synonyms

Viability Homozygous - Subviable

Phenotype associations for Agap1

Significant Not Significant Not tested

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Agap1 data for that phenotype.

All Data: Body Weight Data Agap1 Measurements Heatmap / Table

Phenotype	Allele	Zyg	Life Stage	P Value
increased anti-nuclear antigen antibody level	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	0.0
preweaning lethality, incomplete penetrance	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	n/a	0.0
persistence of hyaloid vascular system	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	6.69E-15
fused cornea and lens	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.32E-9
corneal opacity	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	7.88E-9
decreased circulating insulin level	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.4E-6
abnormal cornea morphology	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	2.58E-6
abnormal lens morphology	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	4.54E-6
cataract	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	4.54E-6
abnormal iris morphology	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	4.78E-6
abnormal cranium morphology	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	2.48E-5
decreased caudal vertebrae number	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	3.19E-5
absent pinna reflex	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	3.43E-5
increased circulating potassium level	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	3.84E-5
increased erythrocyte cell number	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	4.33E-5
increased hematocrit	Agap1^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	5.55E-5

Download data as: TSV XLS

Expression data not available

Xray (124)

Eye Morphology (30)

Agap1^{tm1a(EUCOMM)Wtsi}
Fused cornea and lens, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
corneal opacity, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
corneal opacity, HOM, Male, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
persistence of hyaloid vascular system, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
cataracts, HOM, Male, WTSI

Dysmorphology (7)

Agap1^{tm1a(EUCOMM)Wtsi}
asymmetric snout, abnormal snout morphology, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
malocclusion, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
abnormal snout morphology, short snout, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
abnormal snout morphology, asymmetric snout, HOM, Female, WTSI
Agap1^{tm1a(EUCOMM)Wtsi}
upturned snout, short snout, abnormal snout morphology, HOM, Female, WTSI