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Gene: Agap1

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Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Synonyms
  • Ggap1
  • Centg2

Status Mice
tm1aphenotype data available

Links MGI:2653690   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Agap1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Agap1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased anti-nuclear antigen antibody level Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
preweaning lethality, incomplete penetrance Agap1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
persistence of hyaloid vascular system Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 6.69E-15
fused cornea and lens Agap1tm1a(EUCOMM)Wtsi HOM Male postnatal 1.32E-9
corneal opacity Agap1tm1a(EUCOMM)Wtsi HOM Male postnatal 7.88E-9
decreased circulating insulin level Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.4E-6
abnormal cornea morphology Agap1tm1a(EUCOMM)Wtsi HOM Male postnatal 2.58E-6
abnormal lens morphology Agap1tm1a(EUCOMM)Wtsi HOM Female postnatal 4.54E-6
cataract Agap1tm1a(EUCOMM)Wtsi HOM Female postnatal 4.54E-6
abnormal iris morphology Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.78E-6
abnormal cranium morphology Agap1tm1a(EUCOMM)Wtsi HOM Female postnatal 2.48E-5
decreased caudal vertebrae number Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.19E-5
absent pinna reflex Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.43E-5
increased circulating potassium level Agap1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.84E-5
increased erythrocyte cell number Agap1tm1a(EUCOMM)Wtsi HOM Female postnatal 4.33E-5
increased hematocrit Agap1tm1a(EUCOMM)Wtsi HOM Female postnatal 5.55E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • Anti-nuclear antibody assay
    6 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • X-ray: XRay Images Dorso Ventral
    42 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • Eye Morphology: Images Slit Lamp
    18 Images
  • Eye Morphology: Images Ophthalmoscopy
    12 Images
Legacy Phenotype Associated Images
Xray (124)
  • Agap1tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    WT, Female, WTSI

show all 124 images

Eye Morphology (30)
  • Agap1tm1a(EUCOMM)Wtsi
    fused cornea and lens, HOM, Male, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    Fused cornea and lens, HOM, Male, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    corneal opacity, HOM, Male, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    corneal opacity, HOM, Male, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    Fused cornea and lens, HOM, Male, WTSI

show all 30 images

Dysmorphology (7)
  • Agap1tm1a(EUCOMM)Wtsi
    upturned snout, short snout, abnormal snout morphology, HOM, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    asymmetric snout, abnormal snout morphology, HOM, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    abnormal snout morphology, upturned snout, HOM, Male, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    asymmetric snout, abnormal snout morphology, HOM, Female, WTSI
  • Agap1tm1a(EUCOMM)Wtsi
    malocclusion, HOM, Female, WTSI

show all 7 images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Agap1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Agap1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene