Gene: Alpk3

Order

Name alpha-kinase 3

Synonyms Midori

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2151224    Ensembl Gene    Ensembl Orthologs    My Genes    IDG   

Viability Homozygous - Subviable

Phenotype associations for Alpk3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Alpk3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
enlarged heart Alpk3tm1b(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased heart weight Alpk3tm1b(EUCOMM)Hmgu HOM Female postnatal 0.0
preweaning lethality, incomplete penetrance Alpk3tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
dilated heart left ventricle Alpk3tm1b(EUCOMM)Hmgu HOM Female postnatal 3.15E-21
thick ventricular wall Alpk3tm1b(EUCOMM)Hmgu HOM Female postnatal 3.5E-15
decreased cardiac muscle contractility Alpk3tm1b(EUCOMM)Hmgu HOM Female postnatal 5.28E-8
increased heart left ventricle size Alpk3tm1b(EUCOMM)Hmgu HOM Female postnatal 8.71E-8

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    set of connective tissues
    reproductive system
    musculoskeletal system
    integumental system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Ear 2 (1/482)
Embryo 2 (1/482) (4/4)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482) (2/4)
Hand 2 (1/482)
Head 2 (5/482) (3/4)
Heart 2 (1/482) (2/4)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482) (2/4)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Tail 2 (1/482) (3/4)
Tail somite 2 (1/482) (1/4)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    7 Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Dorso Ventral
    7 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    7 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    2 Images
  • Adult LacZ: LacZ Images Wholemount
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Alpk3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Alpk3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene