Gene: Aff3

Name AF4/FMR2 family, member 3

Synonyms
  • Laf4
  • 3222402O04Rik
  • LAF-4

Status ES CellsMice
tm1a
phenotype data available

Links MGI:106927   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Aff3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Aff3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HET Female Male postnatal 0.0
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HET Male postnatal 7.59E-8
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.6E-7
abnormal incisor morphology Aff3tm1a(EUCOMM)Wtsi HOM Male postnatal 7.8E-7
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 8.0E-7
vertebral transformation Aff3tm1a(EUCOMM)Wtsi HOM Female postnatal 1.9E-6
fusion of vertebral arches Aff3tm1a(EUCOMM)Wtsi HOM Female postnatal 5.1E-6
decreased circulating serum albumin level Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 6.84E-6
decreased grip strength Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 9.24E-6
increased or absent threshold for auditory brainstem response Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.86E-5
decreased circulating fructosamine level Aff3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.74E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/176) (2/2)
Aorta 2 No (2/530)
Blood vessel 2 No
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530) (2/2)
Cerebellum 2 No (6/530)
Cerebral cortex 2 No (6/530)
Eye 2 No (1/530)
Gall bladder 2 No
Heart 2 No (4/530)
Hippocampus 2 No (7/530)
Hypothalamus 2 No (5/529)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530)
Liver 2 No
Lower urinary tract 2 No (3/530) (1/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No (2/176)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530)
Parathyroid gland 2 No (2/516)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/176)
Pituitary gland 2 No (2/530)
Prostate gland 2 No (3/530)
Skeletal muscle tissue 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530)
Striatum 2 No (6/530)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530) (2/2)
Uterus 2 No (1/530)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system nervous system set of connective tissues reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (8)
  • Aff3tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    SPLEEN, HET, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    LUNG, HET, Female, WTSI

show all 8 images

nervous system (4)
  • Aff3tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
reproductive system (2)
  • Aff3tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    OVIDUCT, OVARY, HET, Female, WTSI
respiratory system (2)
  • Aff3tm1a(EUCOMM)Wtsi
    LUNG, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
urinary system (2)
  • Aff3tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    LOWER URINARY TRACT, HET, Female, WTSI
endocrine system (1)
  • Aff3tm1a(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
immune system (1)
  • Aff3tm1a(EUCOMM)Wtsi
    SPLEEN, HET, Male, WTSI
set of connective tissues (1)
  • Aff3tm1a(EUCOMM)Wtsi
    CARTILAGE TISSUE, HET, Female, WTSI

Associated Images

Associated Images
  • Brain Histopathology: Striatal Section
    3 Images
  • Brain Histopathology: Hippocampal section
    1 Images
  • X-ray: XRay Images Dorso Ventral
    77 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    28 Images
  • X-ray: XRay Images Lateral Orientation
    52 Images
  • X-ray: XRay Images Skull Lateral Orientation
    25 Images
  • X-ray: XRay Images Forepaw
    21 Images
Legacy Phenotype Associated Images
Xray (151)
  • Aff3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI

show all 151 images

Brain Histopathology (12)
  • Aff3tm1a(EUCOMM)Wtsi
    HET, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    HET, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    CORPUS CALLOSUM, decreased corpus callosum size, HOM, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    HOM, Male, WTSI

show all 12 images

Eye Morphology (7)
  • Aff3tm1a(EUCOMM)Wtsi
    cornea/lens fusion, HOM, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    corneal opacity, HOM, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    eyelids fail to open, HOM, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    corneal opacity, corneal vascularization, HET, Female, WTSI

show all 7 images

Skin Histopathology (2)
  • Aff3tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Aff3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Aff3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Aff3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene