Phenotype: increased fasted circulating glucose level

Definition increase in the amount of glucose in the blood at some defined time point after eating compared to controls

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Phenotype associations stats

2.32% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased fasted circulating glucose level (79/3411)

1.69% females (57/3373) 1.83% males (62/3397)



Gene variants with increased fasted circulating glucose level

Total number of significant genotype-phenotype associations: 123

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.8E-29
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.03E-14
Sptssb
Sptssbtm1b(KOMP)Mbp
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.19E-14
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.39E-12
Cinp
Cinptm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.01E-12
Syce1
Syce1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.77E-12
Bach1
Bach1tm1.1(KOMP)Vlcg
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 8.15E-12
Ube2w
Ube2wtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 5.78E-11
Phf5a
Phf5aem2Marc
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.34E-9
Dlgap2
Dlgap2em1Mhzh
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 3.88E-9
Rilpl1
Rilpl1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.3E-8
Xkr5
Xkr5tm1b(KOMP)Mbp
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.32E-8
Mrpl3
Mrpl3em1J
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.63E-8
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.28E-7
Pip4k2c
Pip4k2ctm1b(KOMP)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.43E-7
Pitx3
Pitx3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.68E-7
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 2.0E-7
Stim2
Stim2tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.17E-7
Rin3
Rin3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.44E-7
Loxl1
Loxl1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.77E-7
H1foo
H1footm1b(KOMP)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration UC Davis | IMPC 4.19E-7
Cpe
Cpetm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 4.29E-7
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.76E-7
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 5.12E-7
Alg10b
Alg10btm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration BCM | IMPC 5.75E-7
Ap3s1
Ap3s1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 7.18E-7
Prpf31
Prpf31tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 7.7E-7
Efna5
Efna5tm1b(EUCOMM)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.14E-6
Ccnd2
Ccnd2tm1b(KOMP)Mbp
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.31E-6
Mcu
Mcutm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.6E-6
Fbf1
Fbf1tm1a(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 1.66E-6
Vwa8
Vwa8tm1b(EUCOMM)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.91E-6
Clcc1
Clcc1tm1b(KOMP)Mbp
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.0E-6
Trim39
Trim39tm1b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.04E-6
Dnajb7
Dnajb7tm1.1(KOMP)Vlcg
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.66E-6
Chrdl1
Chrdl1em2H
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.66E-6
Tsg101
Tsg101tm1b(EUCOMM)Hmgu
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 3.05E-6
Adora2b
Adora2btm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.5E-6
Daam1
Daam1tm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.06E-6
Bcl11b
Bcl11btm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.43E-6
Ptch2
Ptch2tm3b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.95E-6
Gigyf2
Gigyf2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 5.64E-6
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 6.13E-6
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration ICS | IMPC 7.07E-6
C1qtnf5
C1qtnf5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 9.1E-6
Zgpat
Zgpattm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 9.59E-6
Atp5g2
Atp5g2tm2b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 9.66E-6
Atp5g2
Atp5g2tm2b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 9.66E-6
Med11
Med11tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.02E-5
Ctsm
Ctsmtm1(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.06E-5
Abca7
Abca7tm2b(EUCOMM)Hmgu
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.45E-5
Rnf183
Rnf183tm1b(KOMP)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.45E-5
Cyb561a3
Cyb561a3tm2b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.57E-5
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.62E-5
Nrcam
Nrcamtm2e.1(KOMP)Wtsi
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.71E-5
Atp5l
Atp5ltm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.83E-5
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.02E-5
Nagk
Nagktm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.19E-5
Ccdc120
Ccdc120tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.25E-5
Sorl1
Sorl1tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.3E-5
Nbas
Nbastm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.44E-5
Kntc1
Kntc1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.61E-5
Kntc1
Kntc1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.61E-5
Lcp1
Lcp1tm1e.1(KOMP)Wtsi
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.19E-5
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 3.36E-5
Cox7c
Cox7ctm1b(KOMP)Mbp
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.62E-5
Kars
Karstm2b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration BCM | IMPC 4.01E-5
Mtnr1b
Mtnr1btm1.1(KOMP)Vlcg
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration UC Davis | IMPC 4.16E-5
Col18a1
Col18a1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.22E-5
Ankib1
Ankib1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.52E-5
Cdk5rap3
Cdk5rap3tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 4.72E-5
Cenpe
Cenpetm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 4.77E-5
Nrsn1
Nrsn1tm1.1(KOMP)Vlcg
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 5.61E-5
Lbp
Lbptm1b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 6.01E-5
Mmachc
Mmachctm1.1(NCOM)Mfgc
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 6.8E-5
Toe1
Toe1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 7.63E-5
Dhx30
Dhx30tm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 7.94E-5
Rxfp4
Rxfp4tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 8.47E-5
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 8.5E-5
Ppp2r3a
Ppp2r3atm1(KOMP)Mbp
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 9.14E-5
Spag4
Spag4tm1.1(KOMP)Mbp
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 9.33E-5
Cpsf3
Cpsf3tm1b(EUCOMM)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 9.35E-5

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