Phenotype: increased fasted circulating glucose level

Definition increase in the amount of glucose in the blood at some defined time point after eating compared to controls

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Phenotype associations stats

2.18% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased fasted circulating glucose level (82/3753)

1.54% females (57/3706) 1.69% males (63/3733)



Gene variants with increased fasted circulating glucose level

Total number of significant genotype-phenotype associations: 121

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.8E-29
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.05E-14
Sptssb
Sptssbtm1b(KOMP)Mbp
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.09E-14
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.34E-12
Cinp
Cinptm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 6.33E-12
Syce1
Syce1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.07E-11
Bach1
Bach1tm1.1(KOMP)Vlcg
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.87E-11
Ube2w
Ube2wtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 5.78E-11
Phf5a
Phf5aem2(IMPC)Marc
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.34E-9
Dlgap2
Dlgap2em1(IMPC)Mhzh
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 3.88E-9
Rilpl1
Rilpl1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.23E-8
Xkr5
Xkr5tm1b(KOMP)Mbp
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.39E-8
Ccnd2
Ccnd2tm1b(KOMP)Mbp
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.2E-8
Mrpl3
Mrpl3em1(IMPC)J
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 8.45E-8
H1foo
H1footm1b(KOMP)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration UC Davis | IMPC 1.49E-7
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.76E-7
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 2.12E-7
Pip4k2c
Pip4k2ctm1b(KOMP)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.46E-7
Cpe
Cpetm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 4.28E-7
Loxl1
Loxl1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.46E-7
Pitx3
Pitx3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 5.35E-7
Rin3
Rin3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 5.74E-7
Ap3s1
Ap3s1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 6.93E-7
Zgpat
Zgpattm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 7.13E-7
Prpf31
Prpf31tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 7.7E-7
Efna5
Efna5tm1b(EUCOMM)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.14E-6
Stim2
Stim2tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.16E-6
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.16E-6
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.24E-6
Mcu
Mcutm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.53E-6
Vwa8
Vwa8tm1b(EUCOMM)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.89E-6
Fbf1
Fbf1tm1a(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 1.95E-6
Gdpd2
Gdpd2tm1a(KOMP)Wtsi
HEM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 1.96E-6
Trim39
Trim39tm1b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.49E-6
Tsg101
Tsg101tm1b(EUCOMM)Hmgu
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 3.05E-6
Dnajb7
Dnajb7tm1.1(KOMP)Vlcg
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.94E-6
Daam1
Daam1tm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 3.98E-6
Chrdl1
Chrdl1em1(IMPC)H
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.13E-6
Clcc1
Clcc1tm1b(KOMP)Mbp
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.21E-6
Ptch2
Ptch2tm3b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.89E-6
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration ICS | IMPC 5.58E-6
Gigyf2
Gigyf2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 5.86E-6
Alg10b
Alg10btm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration BCM | IMPC 6.19E-6
Adora2b
Adora2btm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 6.83E-6
Bcl11b
Bcl11btm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 8.87E-6
Atp5g2
Atp5g2tm2b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 9.78E-6
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.01E-5
Ctsm
Ctsmtm1(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 1.06E-5
Rnf183
Rnf183tm1b(KOMP)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.26E-5
C1qtnf5
C1qtnf5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.37E-5
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.54E-5
Cyb561a3
Cyb561a3tm2b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 1.56E-5
Med11
Med11tm1.1(KOMP)Vlcg
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.58E-5
Ogn
Ogntm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.66E-5
Atp5l
Atp5ltm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.81E-5
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 1.88E-5
Abca7
Abca7tm2b(EUCOMM)Hmgu
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 1.97E-5
Sorl1
Sorl1tm1b(EUCOMM)Wtsi
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.09E-5
Nbas
Nbastm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 2.56E-5
Mmachc
Mmachctm1.1(NCOM)Mfgc
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 2.64E-5
Nagk
Nagktm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 2.73E-5
Nrcam
Nrcamtm2e.1(KOMP)Wtsi
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 2.93E-5
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 3.28E-5
Lcp1
Lcp1tm1e.1(KOMP)Wtsi
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.55E-5
Kntc1
Kntc1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.76E-5
Mtnr1b
Mtnr1btm1.1(KOMP)Vlcg
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration UC Davis | IMPC 3.9E-5
Ccdc120
Ccdc120tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 3.92E-5
Kars
Karstm2b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration BCM | IMPC 4.32E-5
Eif4g2
Eif4g2tm1b(KOMP)Wtsi
HET Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 4.34E-5
Ankib1
Ankib1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 4.57E-5
Cenpe
Cenpetm1b(EUCOMM)Hmgu
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 4.73E-5
Aspg
Aspgem1(IMPC)Tcp
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 4.96E-5
Cdk5rap3
Cdk5rap3tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration HMGU | IMPC 5.04E-5
Zfp763
Zfp763em1(IMPC)Wtsi
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration WTSI | IMPC 5.27E-5
Cox7c
Cox7ctm1b(KOMP)Mbp
HET Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 5.46E-5
Lbp
Lbptm1b(EUCOMM)Hmgu
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 6.57E-5
Col18a1
Col18a1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 6.67E-5
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MRC Harwell | IMPC 7.27E-5
D630045J12Rik
D630045J12Riktm1b(KOMP)Wtsi
HOM Female Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 7.43E-5
Nrsn1
Nrsn1tm1.1(KOMP)Vlcg
HOM Female postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 7.63E-5
Dhx30
Dhx30tm1.1(KOMP)Vlcg
HET Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration JAX | IMPC 8.68E-5
Upf3b
Upf3bem1(IMPC)Tcp
HEM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration TCP | IMPC 9.09E-5
Ppp2r3a
Ppp2r3atm1(KOMP)Mbp
HOM Male postnatal increased fasted circulating glucose level Intraperitoneal glucose tolerance test (IPGTT) | Fasted blood glucose concentration MARC | IMPC 9.14E-5

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