Phenotype: increased Ly6C low monocyte number

Definition increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes

MP browserMP:0013025

Phenotype associations stats

1.69% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased Ly6C low monocyte number (13/770)

0.00% females (0/753) 0.00% males (0/744)

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Gene variants with increased Ly6C low monocyte number

Total number of significant genotype-phenotype associations: 13

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 0.0
Tmem127
Tmem127tm1(KOMP)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte percentage WTSI | 3i 0.0
Arhgap30
Arhgap30tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte percentage WTSI | 3i 6.0E-7
Bap1
Bap1tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 9.0E-7
Spink14
Spink14tm1e(KOMP)Wtsi
HOM Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 9.0E-7
Wac
Wactm2b(EUCOMM)Wtsi
HET Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 2.3E-6
Crls1
Crls1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased Ly6C low monocyte number Whole blood peripheral blood leukocyte immunophenotyping | Ly6Clow monocyte number WTSI | 3i 2.12E-5

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