Phenotype: decreased threshold for auditory brainstem response

Definition reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system

MP browserMP:0011968

Phenotype associations stats

0.60% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased threshold for auditory brainstem response (25/4200)

0.13% females (5/3831) 0.08% males (3/3973)

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Gene variants with decreased threshold for auditory brainstem response

Total number of significant genotype-phenotype associations: 29

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Rab10
Rab10em1(IMPC)J
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 3.64E-9
Romo1
Romo1em1(IMPC)KMPC
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 24kHz-evoked ABR Threshold KMPC | IMPC 2.48E-8
Med10
Med10em1(IMPC)J
HET Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 7.0E-8
Dlec1
Dlec1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 2.0E-7
Gm12258
Gm12258tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold ICS | IMPC 2.0E-7
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 12kHz-evoked ABR Threshold MARC | IMPC 5.0E-7
Dnajc17
Dnajc17tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 4.2E-6
Tssk4
Tssk4em1(IMPC)J
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 12kHz-evoked ABR Threshold JAX | IMPC 5.75E-6
Frs2
Frs2tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold MRC Harwell | IMPC 6.0E-6
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 7.6E-6
Zdhhc11
Zdhhc11tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold JAX | IMPC 9.3E-6
Iqgap2
Iqgap2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 9.9E-6
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 1.07E-5
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold JAX | IMPC 1.47E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold HMGU | IMPC 1.8E-5
Bzw1
Bzw1em1(IMPC)J
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 4.23E-5
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.09E-5
Aldh1l1
Aldh1l1tm1b(KOMP)Wtsi
HOM Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.33E-5
Dok7
Dok7tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Hmx2
Hmx2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Plod3
Plod3tm1.1(KOMP)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Reg2
Reg2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Stim2
Stim2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 8.55E-5
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold ICS | IMPC 9.53E-5
Snx29
Snx29tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold ICS | IMPC 9.53E-5

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