Phenotype: decreased threshold for auditory brainstem response

Definition reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system

MP browserMP:0011968

Phenotype associations stats

0.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased threshold for auditory brainstem response (26/3937)

0.20% females (7/3576) 0.11% males (4/3709)

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Gene variants with decreased threshold for auditory brainstem response

Total number of significant genotype-phenotype associations: 29

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Bzw1
Bzw1em1(IMPC)J
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 1.86E-9
Romo1
Romo1em1(IMPC)KMPC
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 24kHz-evoked ABR Threshold KMPC | IMPC 2.48E-8
Med10
Med10em1(IMPC)J
HET Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 3.46E-8
Dlec1
Dlec1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 2.0E-7
Gm12258
Gm12258tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold ICS | IMPC 3.0E-7
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 12kHz-evoked ABR Threshold MARC | IMPC 5.0E-7
Ofcc1
Ofcc1em1(IMPC)J
HOM Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 1.63E-6
Dnajc17
Dnajc17tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 4.2E-6
Frs2
Frs2tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold MRC Harwell | IMPC 5.9E-6
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 6.6E-6
Adamts14
Adamts14em1(IMPC)J
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 8.98E-6
Zdhhc11
Zdhhc11tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold JAX | IMPC 9.9E-6
Iqgap2
Iqgap2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 1.0E-5
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 1.08E-5
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold JAX | IMPC 1.6E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold HMGU | IMPC 1.82E-5
Prpf40a
Prpf40aem1(IMPC)J
HET Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 4.55E-5
Efhd1
Efhd1em1(IMPC)J
HOM Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 4.87E-5
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.13E-5
Aldh1l1
Aldh1l1tm1b(KOMP)Wtsi
HOM Female postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.33E-5
Dok7
Dok7tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Hmx2
Hmx2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Plod3
Plod3tm1.1(KOMP)Wtsi
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Reg2
Reg2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11E-5
Stim2
Stim2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 8.55E-5
Fyb
Fybtm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 9.38E-5

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