Phenotype: increased effector memory CD8-positive, alpha-beta T cell number

Definition increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative

Synonyms
  • increased effector CD8-positive, alpha-beta memory T lymphocyte number
  • increased effector CD8-positive, alpha-beta memory T lymphocyte number
  • increased effector CD8-positive, alpha-beta memory T-cell number
  • increased effector CD8-positive, alpha-beta memory T-cell number
  • increased effector memory CD8-positive, alpha-beta T-cell number
  • increased effector memory CD8-positive, alpha-beta T-lymphocyte number
  • increased effector CD8-positive, alpha-beta memory T-lymphocyte number
  • increased effector CD8-positive, alpha-beta memory T cell number
  • increased effector memory CD8-positive, alpha-beta T lymphocyte number
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Phenotype associations stats

1.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased effector memory CD8-positive, alpha-beta T cell number (22/1328)

1.23% females (16/1301) 1.16% males (15/1298)

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Gene variants with increased effector memory CD8-positive, alpha-beta T cell number

Total number of significant genotype-phenotype associations: 41

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Arhgap30
Arhgap30tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 0.0
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Effector CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Effector CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Pepd
Pepdtm1a(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 5.82E-24
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 1.93E-20
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 1.24E-9
Hmgb1
Hmgb1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 4.3E-9
Mlec
Mlectm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 1.03E-8
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 9.0E-7
Mpg
Mpgtm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 9.0E-7
Ccdc106
Ccdc106tm1a(EUCOMM)Wtsi
HOM Female postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 3.6E-6
Reg3g
Reg3gtm1a(KOMP)Wtsi
HOM Female postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 5.95E-6
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 2.12E-5
Naga
Nagatm1a(EUCOMM)Wtsi
HOM Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 4.57E-5
Dusp3
Dusp3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 6.57E-5
Sytl1
Sytl1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 6.8E-5
Prss53
Prss53em3(IMPC)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 7.67E-5
Arhgap25
Arhgap25tm1a(KOMP)Wtsi
HOM Female Male postnatal increased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 9.65E-5

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