Phenotype: prolonged ST segment

Definition increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized

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Phenotype associations stats

1.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged ST segment (38/2441)

1.44% females (35/2435) 1.52% males (37/2439)



Gene variants with prolonged ST segment

Total number of significant genotype-phenotype associations: 74

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Gal
Galtm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.2E-19
Vps39
Vps39tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 3.13E-19
Tfr2
Tfr2em1Rbrc
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 7.7E-19
Uts2
Uts2tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 8.84E-19
Psmf1
Psmf1tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.05E-18
Atp13a2
Atp13a2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.66E-18
Ddrgk1
Ddrgk1tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 6.0E-18
Pdyn
Pdynem1Rbrc
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.19E-17
Dctn2
Dctn2tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 2.99E-17
Ube2g1
Ube2g1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 4.06E-17
Slc2a2
Slc2a2tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 7.44E-17
Ppp4r1
Ppp4r1em1Rbrc
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.22E-16
Kif2c
Kif2ctm1.1(KOMP)Vlcg
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 4.85E-16
Tgm3
Tgm3tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 5.76E-16
Gucy2c
Gucy2cem1Rbrc
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 6.72E-16
Edn2
Edn2tm1b(KOMP)Mbp
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 7.52E-16
Npsr1
Npsr1tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 9.19E-16
Nin
Nintm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 9.25E-16
Adcyap1r1
Adcyap1r1tm1e.1(KOMP)Wtsi
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 9.79E-16
Trpc5
Trpc5tm1b(KOMP)Wtsi
HEM Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.03E-14
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 2.79E-12
Cck
Ccktm2b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 9.59E-12
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.61E-11
Sept5
Sept5tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 2.57E-11
Trpc5
Trpc5tm1b(KOMP)Wtsi
HOM Female postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 5.71E-11
Tyms
Tymstm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 1.39E-9
Apln
Aplntm1b(KOMP)Wtsi
HEM Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 7.15E-9
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 1.71E-8
Apln
Aplntm1b(KOMP)Wtsi
HOM Female postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 2.18E-8
Dnase1
Dnase1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 5.75E-6
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 5.89E-6
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 9.24E-6
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 9.24E-6
Carf
Carftm1.1(KOMP)Vlcg
HOM Female postnatal prolonged ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.2E-5
Hbq1a
Hbq1atm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 2.78E-5
Clspn
Clspntm1(KOMP)Vlcg
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 3.14E-5
Ptprm
Ptprmem1Rbrc
HOM Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST RBRC | IMPC 3.35E-5
Rwdd3
Rwdd3tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 3.56E-5
Ace
Acetm1.1(KOMP)Vlcg
HET Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 4.58E-5
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 6.62E-5
Klk4
Klk4tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 8.87E-5

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