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Phenotype: prolonged RR interval

Definition
increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate
Synonyms
widened RR interval,  increased RR interval
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged RR interval

Total number of significant genotype-phenotype associations: 129

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 6.29×10-26
Slc29a3
Slc29a3em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.58×10-20
Mmaa
Mmaaem1(IMPC)J 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.39×10-15
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 3.52×10-14
Ndufa8
Ndufa8tm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 8.71×10-14
Maged1
Maged1em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.18×10-13
Dmp1
Dmp1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.24×10-13
Hcn1
Hcn1em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.89×10-13
Trim55
Trim55tm2b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.63×10-13
Selenot
Selenotem1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.47×10-13
Ndufa7
Ndufa7em1(IMPC)Bay 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.00×10-12
Tmem203
Tmem203em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.60×10-12
Six1
Six1em1(IMPC)Mbp 		HET Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.91×10-10
Lcorl
Lcorlem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 5.14×10-10
Slc6a6
Slc6a6em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.51×10-10
Psors1c2
Psors1c2em1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 1.37×10-09
Anapc7
Anapc7em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.39×10-09
Mmab
Mmabem1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 3.88×10-09
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 4.12×10-09
Nadsyn1
Nadsyn1tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 5.40×10-09
Nav1
Nav1em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 7.77×10-09
Myo6
Myo6em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 8.41×10-09
Rab4a
Rab4atm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.51×10-08
Dpp8
Dpp8em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.76×10-08
Cpa5
Cpa5em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.24×10-08
Tfap4
Tfap4tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.95×10-08
Hipk3
Hipk3tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.49×10-08
Ctsa
Ctsatm2b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 8.37×10-08
Cap2
Cap2tm1b(EUCOMM)Wtsi 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 8.90×10-08
Zdhhc22
Zdhhc22em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.20×10-07
Mindy2
Mindy2em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.23×10-07
Try10
Try10em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.47×10-07
Lamtor3
Lamtor3em1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 1.76×10-07
Zbed6
Zbed6em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.82×10-07
Slfn1
Slfn1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.11×10-07
Spa17
Spa17em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.33×10-07
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 2.46×10-07
Hcrt
Hcrttm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.76×10-07
Zfp280d
Zfp280dem1(IMPC)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 2.89×10-07
Smo
Smotm1b(KOMP)Wtsi 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.51×10-07
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 4.13×10-07
Maged1
Maged1em1(IMPC)Mbp 		HEM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 5.77×10-07
Ndufa6
Ndufa6em1(IMPC)Bay 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 6.91×10-07
Pepd
Pepdtm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 7.45×10-07
Smarcc2
Smarcc2em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 8.23×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.76×10-07
Lmtk2
Lmtk2em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.19×10-07
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.03×10-06
Gabre
Gabreem1(IMPC)H 		HEM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.06×10-06
Scoc
Scocem1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.20×10-06
Kcna7
Kcna7em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.24×10-06
Tat
Tatem1(IMPC)J 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.27×10-06
Gbp2
Gbp2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 2.54×10-06
Zfp541
Zfp541em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.95×10-06
Ubl7
Ubl7em1(IMPC)Tcp 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 2.97×10-06
Wbp1l
Wbp1ltm2b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.80×10-06
Afap1l2
Afap1l2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 5.55×10-06
Gabra2
Gabra2em1(IMPC)H 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.65×10-06
Il18r1
Il18r1em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 7.58×10-06
Chmp2b
Chmp2bem1(IMPC)Mbp 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.10×10-06
Pak2
Pak2em1(IMPC)H 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 8.48×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 8.67×10-06
Dgkb
Dgkbem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 8.89×10-06
Got1
Got1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.29×10-06
Spg11
Spg11em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.77×10-06
Btnl4
Btnl4em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 9.88×10-06
Fkbp4
Fkbp4em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.06×10-05
Efhb
Efhbem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.10×10-05
Pygm
Pygmem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.12×10-05
Il33
Il33tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.26×10-05
Ap4e1
Ap4e1em2(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.27×10-05
P3h1
P3h1tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.34×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.35×10-05
Tnip1
Tnip1tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.50×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 1.67×10-05
Agpat1
Agpat1tm1.1(KOMP)Vlcg 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.76×10-05
Brd3
Brd3em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.00×10-05
Scarb2
Scarb2em2(IMPC)Tcp 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 2.11×10-05
Poli
Politm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.31×10-05
Arl5a
Arl5aem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.39×10-05
Ubap2l
Ubap2lem1(IMPC)Bay 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 2.58×10-05
Rfc5
Rfc5em1(IMPC)J 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.62×10-05
Arv1
Arv1em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.80×10-05
Spty2d1
Spty2d1em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.95×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.16×10-05
Rnd2
Rnd2em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.20×10-05
Ptpn18
Ptpn18em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.34×10-05
Ogn
Ogntm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.55×10-05
Trip13
Trip13tm1.1(KOMP)Vlcg 		HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.70×10-05
Ehhadh
Ehhadhtm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.82×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.17×10-05
Sppl3
Sppl3em1(IMPC)Bay 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 4.23×10-05
Ndrg1
Ndrg1tm2b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.36×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.42×10-05
Cox7a2l
Cox7a2lem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.56×10-05
Masp1
Masp1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.59×10-05
Rnf166
Rnf166em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.71×10-05
Eif3k
Eif3kem1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.95×10-05
1700030J22Rik
1700030J22Rikem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.02×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.09×10-05
Tg
Tgem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.21×10-05
Spock1
Spock1em1(IMPC)H 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.29×10-05
Atp8b1
Atp8b1em1(IMPC)Tcp 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 6.29×10-05
Blcap
Blcapem1(IMPC)J 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.42×10-05
Dcps
Dcpstm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.51×10-05
Tor1a
Tor1aem1(IMPC)H 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 7.19×10-05
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 7.81×10-05
Smpdl3a
Smpdl3aem1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 8.50×10-05
Fam118a
Fam118aem1(IMPC)J 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 8.72×10-05
Tex21
Tex21em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 8.74×10-05
Tox
Toxtm1b(KOMP)Wtsi 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.87×10-05
Pcm1
Pcm1em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 9.08×10-05
Ist1
Ist1em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.13×10-05
Spock1
Spock1em1(IMPC)H 		HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.28×10-05
Tbcc
Tbccem1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.41×10-05
Tex2
Tex2em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.59×10-05
Usp38
Usp38tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.60×10-05
Gcsh
Gcshem1(IMPC)H 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.66×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

1.93% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged RR interval (116/6012)

0.82% females (49/5989) 1.10% males (66/5981)

Select a parameter    



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