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Phenotype: decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Definition
a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms
reduced CD4-positive, CD25-positive, alpha-beta regulatory T-cell number,  decreased CD4-positive, CD25-positive, alpha-beta Treg number,  decreased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number,  reduced CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number,  reduced CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number,  reduced CD4-positive, CD25-positive, alpha-beta Treg number,  decreased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number,  reduced CD4-positive, CD25-positive, alpha-beta regulatory T cell number,  decreased CD4-positive, CD25-positive, alpha-beta regulatory T-cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Total number of significant genotype-phenotype associations: 8

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.18×10-36
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.30×10-20
Cd27
Cd27em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.16×10-07

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

0.63% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number (5/796)

0.61% females (2/330) 0.91% males (3/330)

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