Phenotype: increased red blood cell distribution width

Definition higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism

Synonyms
  • high RDW
  • high RDW
  • high red blood cell distribution width
  • high red blood cell distribution width
  • increased red blood cell size variability
  • increased erythrocyte distribution width
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Phenotype associations stats

1.69% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased red blood cell distribution width (37/2194)

0.97% females (21/2165) 1.55% males (34/2190)



Gene variants with increased red blood cell distribution width

Total number of significant genotype-phenotype associations: 57

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 0.0
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.92E-30
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 6.8E-20
Fbxo38
Fbxo38em2Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 9.28E-16
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.19E-15
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.83E-13
Prkab1
Prkab1em2Mbp
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width UC Davis | IMPC 4.53E-13
Etaa1
Etaa1em1Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 1.31E-9
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.03E-8
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.19E-8
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width RBRC | IMPC 1.47E-8
Galnt18
Galnt18tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.25E-7
Atp5e
Atp5etm1b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.74E-7
Rft1
Rft1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.82E-7
3830406C13Rik
3830406C13Riktm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.16E-7
Sgsm1
Sgsm1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.45E-6
Becn1
Becn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 2.74E-6
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.22E-6
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 5.51E-6
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 6.05E-6
Vps13c
Vps13ctm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 7.11E-6
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 7.63E-6
Trappc10
Trappc10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 8.3E-6
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.06E-5
Slc25a30
Slc25a30tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.15E-5
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.35E-5
Cand2
Cand2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.56E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 1.64E-5
4930591A17Rik
4930591A17Riktm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.73E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.95E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.13E-5
Xkr5
Xkr5tm1b(KOMP)Mbp
HOM Female postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 3.47E-5
Retreg3
Retreg3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.59E-5
Dact3
Dact3tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.96E-5
Lpin2
Lpin2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 5.01E-5
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 5.6E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 5.88E-5
Natd1
Natd1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 7.15E-5

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