Phenotype: increased red blood cell distribution width

Definition higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism

Synonyms
  • high RDW
  • high RDW
  • high red blood cell distribution width
  • high red blood cell distribution width
  • increased red blood cell size variability
  • increased erythrocyte distribution width
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Related
Synonyms
  • Anisocytosis
  • Anisocytosis
  • anisocytosis
  • anisocytosis

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Phenotype associations stats

1.78% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased red blood cell distribution width (47/2636)

1.06% females (27/2558) 1.78% males (46/2587)



Gene variants with increased red blood cell distribution width

Total number of significant genotype-phenotype associations: 75

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width RBRC | IMPC 0.0
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.02E-30
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 6.8E-20
Fbxo38
Fbxo38em2(IMPC)Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 9.28E-16
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.33E-15
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.83E-13
Pdzd8
Pdzd8tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.0E-12
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 4.13E-12
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.9E-10
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.1E-9
Etaa1
Etaa1em1(IMPC)Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 1.31E-9
Crlf3
Crlf3em1(IMPC)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.66E-9
Becn1
Becn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 5.74E-9
Hpf1
Hpf1em1(IMPC)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.14E-8
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.27E-8
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width RBRC | IMPC 1.48E-8
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.37E-8
Prkab1
Prkab1em2(IMPC)Mbp
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width UC Davis | IMPC 2.87E-8
Kat2b
Kat2bem1(IMPC)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.38E-7
Galnt18
Galnt18tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.8E-7
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.06E-7
Atp5e
Atp5etm1b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.36E-7
3830406C13Rik
3830406C13Riktm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.4E-7
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.63E-6
Sgsm1
Sgsm1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.32E-6
Sdc4
Sdc4tm2b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 4.76E-6
Lpin2
Lpin2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 5.37E-6
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 5.81E-6
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 7.63E-6
Fbxo11
Fbxo11tm2b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.02E-5
Vps13c
Vps13ctm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 1.25E-5
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 1.58E-5
Slc25a30
Slc25a30tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.63E-5
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.8E-5
Trappc10
Trappc10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.82E-5
Dact3
Dact3tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.07E-5
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.2E-5
Cand2
Cand2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.49E-5
4930591A17Rik
4930591A17Riktm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.55E-5
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.6E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.67E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 2.73E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.15E-5
Retreg3
Retreg3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.66E-5
Notch3
Notch3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width UC Davis | IMPC 5.82E-5
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 6.99E-5
Stx5a
Stx5atm1b(EUCOMM)Hmgu
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 8.98E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 9.81E-5

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