Phenotype: increased red blood cell distribution width

Definition higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism

Synonyms
  • high RDW
  • high RDW
  • high red blood cell distribution width
  • high red blood cell distribution width
  • increased red blood cell size variability
  • increased erythrocyte distribution width
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Related
Synonyms
  • anisocytosis
  • anisocytosis
  • Anisocytosis
  • Anisocytosis

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Phenotype associations stats

1.78% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased red blood cell distribution width (51/2870)

1.04% females (29/2784) 1.78% males (50/2816)



Gene variants with increased red blood cell distribution width

Total number of significant genotype-phenotype associations: 81

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 0.0
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.0E-30
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 6.8E-20
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.42E-15
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 6.16E-14
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 2.83E-13
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.77E-12
Pdzd8
Pdzd8tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 4.55E-12
Fbxo38
Fbxo38em2(IMPC)Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 7.81E-11
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.91E-10
Etaa1
Etaa1em1(IMPC)Marc
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 1.5E-9
Crlf3
Crlf3em1(IMPC)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.66E-9
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.94E-9
Becn1
Becn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 5.68E-9
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width RBRC | IMPC 9.13E-9
Hpf1
Hpf1em1(IMPC)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.13E-8
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.27E-8
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.36E-8
Prkab1
Prkab1em2(IMPC)Mbp
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width UC Davis | IMPC 2.4E-8
Kat2b
Kat2bem1(IMPC)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.4E-7
Galnt18
Galnt18tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.79E-7
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.81E-7
Atp5e
Atp5etm1b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.43E-7
3830406C13Rik
3830406C13Riktm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 3.45E-7
Klhl42
Klhl42tm1b(EUCOMM)Hmgu
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 8.2E-7
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 1.52E-6
Sgsm1
Sgsm1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.3E-6
Micu2
Micu2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 4.01E-6
Sdc4
Sdc4tm2b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 4.44E-6
Lpin2
Lpin2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 5.26E-6
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 5.61E-6
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 5.73E-6
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 7.63E-6
Fbxo11
Fbxo11tm2b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 9.68E-6
Vps13c
Vps13ctm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 1.24E-5
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 1.58E-5
Slc25a30
Slc25a30tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.67E-5
Trappc10
Trappc10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 1.93E-5
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.03E-5
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.21E-5
Nutm1
Nutm1tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.5E-5
Cand2
Cand2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.55E-5
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.62E-5
4930591A17Rik
4930591A17Riktm1a(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 2.62E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.22E-5
Retreg3
Retreg3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MRC Harwell | IMPC 3.81E-5
Dact3
Dact3tm1b(KOMP)Wtsi
HOM Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width WTSI | IMPC 4.88E-5
Notch3
Notch3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width UC Davis | IMPC 5.36E-5
Phf5a
Phf5aem2(IMPC)Marc
HET Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width MARC | IMPC 5.87E-5
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width TCP | IMPC 7.12E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 8.63E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Male postnatal increased red blood cell distribution width Hematology | Red blood cell distribution width HMGU | IMPC 9.95E-5

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