Definition
reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative
Synonyms
reduced transitional one stage B-cell number,
reduced transitional one stage B-lymphocyte number,
reduced T1 stage B cell number,
decreased transitional one stage B lymphocyte number,
decreased transitional one stage B-cell number,
decreased T1 stage B cell number,
decreased transitional one stage B-lymphocyte number,
reduced transitional one stage B lymphocyte number
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased transitional stage T1 B cell number
Total number of significant genotype-phenotype associations: 3
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Cttnbp2 Cttnbp2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Pepd Pepdtm1a(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 |