Phenotype: decreased prepulse inhibition

Definition decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus

Synonyms
  • decreased PPI
  • decreased PPI
  • reduced PPI
  • reduced PPI
  • reduced prepulse inhibition
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MP browserMP:0009142

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Phenotype associations stats

2.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased prepulse inhibition (85/3048)

2.56% females (78/3043) 2.43% males (74/3046)

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Gene variants with decreased prepulse inhibition

Total number of significant genotype-phenotype associations: 156

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 MRC Harwell | IMPC 7.86E-33
Tmtc4
Tmtc4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 3.24E-19
Vgf
Vgfem1H
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 4.22E-18
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - Global MRC Harwell | IMPC 7.03E-18
Nin
Nintm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 RBRC | IMPC 5.03E-17
Nedd4l
Nedd4ltm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 2.68E-13
Mecom
MecomJbo
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 MRC Harwell | EuroPhenome 5.42E-13
Mat2a
Mat2atm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 1.05E-11
Fbxo11
Fbxo11Jf
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 MRC Harwell | EuroPhenome 1.75E-11
Crybg1
Crybg1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 7.7E-11
Slc4a10
Slc4a10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 4.43E-10
Nsd3
Nsd3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 1.39E-9
Retreg3
Retreg3tm2b(EUCOMM)Wtsi
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 3.95E-9
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 4.61E-9
Caskin1
Caskin1em1Mbp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 1.45E-8
Setd3
Setd3tm1.1(NCOM)Mfgc
HOM Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 2.3E-8
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP4 MRC Harwell | MGP 7.58E-8
Adnp2
Adnp2em1Tcp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 TCP | IMPC 1.07E-7
Ctsk
Ctsktm1b(EUCOMM)Hmgu
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 1.14E-7
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 1.81E-7
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi
HET Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 HMGU | IMPC 2.12E-7
Mipol1
Mipol1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI1 HMGU | IMPC 2.84E-7
Arrb1
Arrb1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 3.32E-7
Tulp3
Tulp3tm1b(EUCOMM)Hmgu
HET Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 3.39E-7
Laptm4b
Laptm4btm1e.1(KOMP)Wtsi
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 TCP | IMPC 3.5E-7
Tox
Toxtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 4.76E-7
Slc24a5
Slc24a5tm1b(KOMP)Mbp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 6.35E-7
Tprn
Tprntm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 7.1E-7
Camk1
Camk1tm2b(EUCOMM)Hmgu
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 BCM | IMPC 7.5E-7
Ifi44
Ifi44tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 1.22E-6
Lef1
Lef1tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 1.58E-6
Flot2
Flot2tm2e(EUCOMM)Wtsi
HOM Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 1.63E-6
Hunk
Hunktm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 1.77E-6
Patl1
Patl1tm1b(EUCOMM)Wtsi
HET Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 BCM | IMPC 1.9E-6
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 2.07E-6
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 2.1E-6
Cops7a
Cops7atm1b(KOMP)Mbp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 2.87E-6
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 JAX | IMPC 2.98E-6
Ntrk2
Ntrk2tm1b(EUCOMM)Wtsi
HET Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 3.24E-6
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 3.56E-6
Doxl2
Doxl2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 3.58E-6
Bend3
Bend3tm1b(KOMP)Mbp
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MARC | IMPC 4.5E-6
Atp6v1c1
Atp6v1c1tm1b(NCOM)Mfgc
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 4.54E-6
Stim2
Stim2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 4.97E-6
Spin1
Spin1tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 5.26E-6
Fkbp10
Fkbp10tm2a(EUCOMM)Wtsi
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 5.51E-6
Marveld2
Marveld2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - Global MRC Harwell | IMPC 5.62E-6
Otoa
Otoatm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 5.85E-6
Lonp1
Lonp1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - Global HMGU | IMPC 7.66E-6
Ostes
Ostes
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP3 MRC Harwell | EuroPhenome 8.09E-6
Nmb
Nmbtm1.1(KOMP)Vlcg
HOM Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 JAX | IMPC 1.13E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 1.17E-5
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 HMGU | IMPC 1.24E-5
Pdik1l
Pdik1lem1Mbp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 1.27E-5
Marc2
Marc2tm2a(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 1.35E-5
Hmx3
Hmx3tm1Ebo
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP3 WTSI | EuroPhenome 1.64E-5
Nisch
Nischtm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 1.65E-5
Celsr1
Celsr1Scy
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP3 MRC Harwell | EuroPhenome 1.68E-5
Dennd2d
Dennd2dtm2b(KOMP)Mbp
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 JAX | IMPC 1.73E-5
Fam162a
Fam162atm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 1.96E-5
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 2.03E-5
Atg4b
Atg4bem1Marc
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MARC | IMPC 2.06E-5
C9
C9tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 JAX | IMPC 2.24E-5
Myh1
Myh1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 JAX | IMPC 2.25E-5
Colca2
Colca2tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 3.02E-5
Atp2a2
Atp2a2tm1b(EUCOMM)Hmgu
HET Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI1 MRC Harwell | IMPC 3.18E-5
Gh
Ghtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 3.42E-5
Gh
Ghtm1.1(KOMP)Vlcg
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 3.42E-5
Notch3
Notch3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 3.68E-5
Fcgr3
Fcgr3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 4.03E-5
Ctc1
Ctc1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 4.27E-5
Clvs1
Clvs1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 4.33E-5
Stbd1
Stbd1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 TCP | IMPC 4.39E-5
Hnf4a
Hnf4atm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 HMGU | IMPC 4.49E-5
Adra2a
Adra2atm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 UC Davis | IMPC 4.5E-5
Mib2
Mib2tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 5.86E-5
Trpc3
Trpc3Mwk
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Global prepulse inhibition MRC Harwell | EuroPhenome 6.09E-5
Ermp1
Ermp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 6.83E-5
Abcc5
Abcc5em1H
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 MRC Harwell | IMPC 7.0E-5
Crtc1
Crtc1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased prepulse inhibition Acoustic Startle&PPI | Prepulse inhibition - PP2 ICS | EuroPhenome 7.57E-5
Gipc3
Gipc3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 JAX | IMPC 7.82E-5
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MRC Harwell | IMPC 8.39E-5
Stard10
Stard10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI4 MRC Harwell | IMPC 8.52E-5
Nme6
Nme6tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI3 JAX | IMPC 8.82E-5
Adgrv1
Adgrv1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 UC Davis | IMPC 9.18E-5
Ezh1
Ezh1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 MARC | IMPC 9.2E-5
Slc5a5
Slc5a5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased prepulse inhibition Acoustic Startle and Pre-pulse Inhibition (PPI) | % Pre-pulse inhibition - PPI2 JAX | IMPC 9.88E-5

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