Phenotype: increased circulating iron level

Phenotype associations stats

1.27% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating iron level (30/2371)

1.06% females (25/2363) 0.77% males (18/2352)

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Gene variants with increased circulating iron level

Total number of significant genotype-phenotype associations: 43

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.37E-18
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.52E-12
Tfr2
Tfr2em1Rbrc
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron RBRC | IMPC 3.85E-10
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.45E-8
Sst
Ssttm1b(KOMP)Wtsi
HOM Male postnatal increased circulating iron level Clinical Chemistry | Iron RBRC | IMPC 2.96E-8
Myl4
Myl4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | EuroPhenome 8.03E-8
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | IMPC 1.22E-7
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | EuroPhenome 1.85E-7
Ddhd1
Ddhd1tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.53E-7
Dll1
Dll1m1Mhda
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | EuroPhenome 2.58E-7
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | IMPC 5.83E-7
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 7.53E-7
Zfyve28
Zfyve28tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.5E-6
Sema3f
Sema3ftm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 3.4E-6
Evl
Evltm1b(KOMP)Wtsi
HOM Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 4.28E-6
Slc1a1
Slc1a1tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron JAX | IMPC 8.67E-6
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.33E-5
Mapkapk2
Mapkapk2tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.45E-5
Daam1
Daam1tm1b(EUCOMM)Hmgu
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.63E-5
Fnip2
Fnip2tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.03E-5
Nek9
Nek9tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.71E-5
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 3.52E-5
Prrg2
Prrg2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.46E-5
Fam122c
Fam122ctm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.75E-5
Exoc3l2
Exoc3l2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 5.43E-5
Prkcz
Prkcztm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | MGP 6.29E-5
Polr3f
Polr3ftm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 6.43E-5
Tamm41
Tamm41tm1(NCOM)Cmhd
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron CMHD | EuroPhenome 6.63E-5
L3mbtl2
L3mbtl2tm2a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 8.5E-5
Lyplal1
Lyplal1tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 8.61E-5

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