Phenotype: increased circulating iron level

Definition elevation in the concentration of iron in the blood

Synonyms
  • hyperferremia
  • hyperferremia
  • hyperferraemia
  • hyperferraemia
Related
Synonyms
Increased serum iron

MP browserMP:0008810

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Phenotype associations stats

1.21% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating iron level (35/2881)

1.13% females (32/2824) 0.67% males (19/2821)

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Gene variants with increased circulating iron level

Total number of significant genotype-phenotype associations: 51

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 5.3E-19
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.85E-12
Tfr2
Tfr2em1(IMPC)Rbrc
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron RBRC | IMPC 2.25E-9
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.02E-8
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | IMPC 6.5E-8
Myl4
Myl4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | EuroPhenome 8.03E-8
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | EuroPhenome 1.85E-7
Ddhd1
Ddhd1tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.02E-7
Dll1
Dll1m1Mhda
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | EuroPhenome 2.58E-7
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 7.69E-7
Otud7b
Otud7btm1b(EUCOMM)Wtsi
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.24E-6
Zfyve28
Zfyve28tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.73E-6
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron HMGU | EuroPhenome 2.86E-6
Sema3f
Sema3ftm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 3.0E-6
Slc1a1
Slc1a1tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron JAX | IMPC 3.01E-6
Evl
Evltm1b(KOMP)Wtsi
HOM Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 4.31E-6
Boc
Boctm1b(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 5.36E-6
Ptprd
Ptprdtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 1.05E-5
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.3E-5
Mapkapk2
Mapkapk2tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.39E-5
Daam1
Daam1tm1b(EUCOMM)Hmgu
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 1.72E-5
Fnip2
Fnip2tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 2.41E-5
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 3.58E-5
Exoc3l2
Exoc3l2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.14E-5
Fam122c
Fam122ctm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.25E-5
Prrg2
Prrg2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.71E-5
Nek9
Nek9tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 4.91E-5
Prkcz
Prkcztm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | EuroPhenome 6.29E-5
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | EuroPhenome 6.59E-5
Tamm41
Tamm41tm1(NCOM)Cmhd
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron CMHD | EuroPhenome 6.63E-5
Lyplal1
Lyplal1tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron MRC Harwell | IMPC 8.2E-5
Fam213a
Fam213aem1(IMPC)Marc
HOM Female Male postnatal increased circulating iron level Clinical Chemistry | Iron MARC | IMPC 8.6E-5
Leprot
Leprottm2a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 8.91E-5
Mast2
Mast2tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 9.19E-5
Ift140
Ift140tm1a(KOMP)Wtsi
HET Male postnatal increased circulating iron level Clinical Chemistry | Iron WTSI | IMPC 9.22E-5

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