Definition
greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli
Synonyms
increased DC2 cell number,
increased plasmacytoid T cell number,
increased T-associated plasma cells cell number,
increased plasmacytoid monocytes cell number,
increased lymphoid dendritic cell number,
increased PDC cell number,
increased pDC cell number
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with increased plasmacytoid dendritic cell number
Total number of significant genotype-phenotype associations: 5
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Arhgef1 Arhgef1tm1a(EUCOMM)Wtsi |
HOM | Early adult | increased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | increased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | increased plasmacytoid dendritic cell number | Plasmacytoid DC - % of DC Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | increased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Alkbh1 Alkbh1tm1b(EUCOMM)Hmgu |
HET | Late adult | increased plasmacytoid dendritic cell number | pDCs Immunophenotyping |
HMGU IMPC |
9.18×10-05 |