Phenotype: decreased mature B cell number

Definition reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex

Synonyms
  • decreased number of mature B-lymphocytes
  • decreased number of mature B-lymphocytes
  • decreased number of mature B cells
  • decreased number of mature B cells
  • reduced mature B cell number
  • decreased number of mature B lymphocytes
  • decreased number of mature B-cells
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Related
Synonyms
  • absent B-1 B cells
  • absent B-1 B cells
  • absent B-1a cells
  • absent B-1a cells
  • absent B-1b cells
  • absent B-2 B cells
  • absent follicular B cells
  • absent germinal center B cells
  • absent marginal zone B cells
  • absent mature B cells
  • absent memory B cells
  • absent plasma cells
  • decreased B-1 B cell number
  • decreased B-1a cell number
  • decreased B-1b cell number
  • decreased B-2 B cell number
  • decreased early germinal center B cell number
  • decreased follicular B cell number
  • decreased germinal center B cell number
  • decreased late germinal center B cell number
  • decreased marginal zone B cell number
  • decreased marginal zone precursor B cell number
  • decreased memory B cell number
  • decreased naive B cell number
  • decreased plasma cell number
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MP browserMP:0008211

Phenotype associations stats

1.87% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased mature B cell number (29/1553)

1.28% females (19/1481) 1.19% males (18/1517)

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Gene variants with decreased mature B cell number

Total number of significant genotype-phenotype associations: 60

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Aicda
Aicdatm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased follicular B cell number Mesenteric Lymph Node Immunophenotyping | Follicular B cells - % of B2 cells WTSI | 3i 0.0
Aicda
Aicdatm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased late germinal center B cell number Mesenteric Lymph Node Immunophenotyping | Late germinal centre B cells - % of CD45+ WTSI | 3i 0.0
Arhgap17
Arhgap17tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased B-1a cell number Spleen Immunophenotyping | B1a cells - % of CD45+ WTSI | 3i 0.0
Arhgap17
Arhgap17tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased follicular B cell number Spleen Immunophenotyping | Follicular B cells - % of B2 cells WTSI | 3i 0.0
Arhgap17
Arhgap17tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 0.0
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased marginal zone B cell number Spleen Immunophenotyping | Marginal zone B cells - % of B2 cells WTSI | 3i 0.0
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased marginal zone precursor B cell number Spleen Immunophenotyping | Marginal zone precursor B cells - % of CD45+ WTSI | 3i 0.0
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Bone marrow immunophenotyping | Mature B cells (Hardy fraction F) - % of CD45+ WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased follicular B cell number Spleen Immunophenotyping | Follicular B cells - % of B2 cells WTSI | 3i 0.0
Brd2
Brd2em1(IMPC)Wtsi
HET Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 0.0
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell number WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased marginal zone B cell number Spleen Immunophenotyping | Marginal zone B cells - % of B2 cells WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Bone marrow immunophenotyping | Mature B cells (Hardy fraction F) - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased follicular B cell number Spleen Immunophenotyping | Follicular B cells - % of CD45+ WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased B-2 B cell number Spleen Immunophenotyping | Total B2 cells - % of CD45+ WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell number WTSI | 3i 0.0
Gm5544
Gm5544tm1a(KOMP)Wtsi
HET Female Male postnatal decreased marginal zone B cell number Spleen Immunophenotyping | Marginal zone B cells - % of B2 cells WTSI | 3i 0.0
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mature B cell number Bone marrow immunophenotyping | Mature B cells (Hardy fraction F) - % of B220+ WTSI | 3i 0.0
Irgm1
Irgm1em1(IMPC)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell number WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased early germinal center B cell number Mesenteric Lymph Node Immunophenotyping | Early germinal centre B cells - % of CD45+ WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased germinal center B cell number Mesenteric Lymph Node Immunophenotyping | Germinal centre B cells - % of B2 cells WTSI | 3i 0.0
Tmem127
Tmem127tm1(KOMP)Wtsi
HOM Female Male postnatal decreased B-2 B cell number Mesenteric Lymph Node Immunophenotyping | Total B2 cells - % of CD45+ WTSI | 3i 0.0
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 3.68E-12
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage MRC Harwell | EuroPhenome 1.62E-9
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage MRC Harwell | EuroPhenome 4.05E-9
Plcg2
Plcg2Ali14
HET Female Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 2.09E-7
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 4.0E-7
Ncf2
Ncf2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 4.0E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | MGP 1.8E-5
Far1
Far1em1(IMPC)Wtsi
HET Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell number WTSI | 3i 1.82E-5
Elmo1
Elmo1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 1.87E-5
Arid1b
Arid1btm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mature B cell number Whole blood peripheral blood leukocyte immunophenotyping | IgD+ mature B cell percentage WTSI | 3i 3.11E-5
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 4.09E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | MGP 4.45E-5
Fam110b
Fam110btm1e(EUCOMM)Wtsi
HET Female Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 4.84E-5
Spns2
Spns2tm1a(KOMP)Wtsi
HOM Female postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 4.95E-5

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