Definition
reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells
Synonyms
reduced B-2 cell number,
decreased number of B-2 cells
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased B-2 B cell number
Total number of significant genotype-phenotype associations: 6
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | Total B2 cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | Total B2 cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
HMGU IMPC |
2.22×10-11 | |
| Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
CCP-IMG IMPC |
9.67×10-11 | |
| Pepd Pepdtm1b(KOMP)Wtsi |
HOM | Late adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
HMGU IMPC |
1.91×10-05 |