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Phenotype: decreased marginal zone B cell number

Definition
reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
Synonyms
reduced marginal zone B cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased marginal zone B cell number

Total number of significant genotype-phenotype associations: 5

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased marginal zone B cell number Marginal zone B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased marginal zone B cell number Marginal zone B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gm5544
Gm5544tm1a(KOMP)Wtsi 		HET   Early adult decreased marginal zone B cell number Marginal zone B cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased marginal zone B cell number MZB (CD21/35 high)
Immunophenotyping		 HMGU
IMPC		 9.79×10-08

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

0.97% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased marginal zone B cell number (4/411)

2.56% females (1/39) 2.63% males (1/38)

Select a parameter    



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