Definition
reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli
Synonyms
reduced plasmacytoid monocytes cell number,
decreased T-associated plasma cells cell number,
decreased lymphoid dendritic cell number,
decreased DC2 cell number,
reduced PDC cell number,
decreased plasmacytoid monocytes cell number,
reduced lymphoid dendritic cell number,
decreased PDC cell number,
reduced DC2 cell number,
reduced T-associated plasma cells cell number,
decreased pDC cell number,
reduced pDC cell number,
decreased plasmacytoid T cell number,
reduced plasmacytoid dendritic cell number,
reduced plasmacytoid T cell number
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased plasmacytoid dendritic cell number
Total number of significant genotype-phenotype associations: 5
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Pclaf Pclaftm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased plasmacytoid dendritic cell number | Plasmacytoid DC - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Vps13a Vps13atm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased plasmacytoid dendritic cell number | Plasmacytoid DC - % of DC Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Tyk2 Tyk2tm2b(EUCOMM)Hmgu |
HOM | Late adult | decreased plasmacytoid dendritic cell number | pDCs Immunophenotyping |
HMGU IMPC |
2.53×10-05 |