Definition
reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Synonyms
decreased CD8+ T cell number,
reduced CD8+ T cell number,
reduced CD8-positive T cell number,
decreased CD8-positive T cell number
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased CD8-positive, alpha-beta T cell number
Total number of significant genotype-phenotype associations: 42
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Arhgef1 Arhgef1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Brd2 Brd2em1(IMPC)Wtsi |
HET | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Clpp Clpptm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Effector CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD8+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased KLRG1+ CD8 alpha-beta T cell number | KLRG1+ CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD8+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Hbs1l Hbs1ltm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Rwdd1 Rwdd1tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
| Traf2 Traf2tm1a(EUCOMM)Wtsi |
HET | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Psmb11 Psmb11em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
8.65×10-21 | |
| Elk4 Elk4tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
6.47×10-10 | |
| Card11 Card11em1(IMPC)Ccpcz |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Naïve CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
1.12×10-09 | |
| Usp12 Usp12tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
1.75×10-09 | |
| Nr1d2 Nr1d2tm1Dgen |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
4.92×10-09 | |
| Apbb1ip Apbb1ipem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
5.40×10-08 | |
| Acp2 Acp2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
1.26×10-07 | |
| Fam234b Fam234btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
3.98×10-07 | |
| Cpm Cpmem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
8.07×10-07 | |
| Nub1 Nub1tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
CCP-IMG IMPC |
1.08×10-06 | |
| Tmprss6 Tmprss6tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
ICS IMPC |
3.88×10-06 | |
| Asb7 Asb7em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
7.21×10-06 | |
| Aldh2 Aldh2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
7.68×10-06 | |
| Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
CCP-IMG IMPC |
1.71×10-05 | |
| Bahd1 Bahd1tm2b(KOMP)Wtsi |
HET | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | CD8 CD44+CD62L+ T cells Immunophenotyping |
ICS IMPC |
1.91×10-05 | |
| Serf1 Serf1tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
2.30×10-05 | |
| Rnase10 Rnase10tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
3.07×10-05 | |
| Prss50 Prss50tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
3.89×10-05 | |
| Gper1 Gper1tm1Dgen |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
4.19×10-05 | |
| Prpsap2 Prpsap2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
4.23×10-05 | |
| Rnf169 Rnf169tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
5.08×10-05 | |
| Pank2 Pank2em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
8.60×10-05 |