Phenotype: decreased CD8-positive, alpha-beta T cell number
Definition reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Synonyms
- reduced CD8+ T cell number
- reduced CD8+ T cell number
- decreased CD8+ T cell number
- decreased CD8+ T cell number
- reduced CD8-positive T cell number
- decreased CD8-positive T cell number
Related
Synonyms
Synonyms
- Absence of CD8-positive T cells
- Absence of CD8-positive T cells
- absent CD8-positive, alpha-beta T cells
- absent CD8-positive, alpha-beta T cells
- decreased CD8-positive, CD25-positive alpha-beta T cell number
- decreased CD8-positive, alpha-beta memory T cell number
- decreased CD8-positive, naive alpha-beta T cell number
- decreased KLRG1+ CD8 alpha beta T cell number
- decreased Tc17 cell number
- decreased central memory CD8 positive, alpha-beta T cell number
- decreased effector memory CD8-positive, alpha-beta T cell number
Procedure
- Immunophenotyping (IMPC, v1)
- Buffy coat peripheral blood leukocyte immunophenotyping (MGP, v1)
- FACS (ICS, v1)
- FACs Analysis (ESLIM, v1)
- FACs Analysis (M-G-P, v1)
- Immunophenotyping (ICS, v2)
- Immunophenotyping (TCPLA, v1)
- Immunophenotyping (UCDLA, v1)
- Immunophenotyping (HMGULA, v1)
- Immunophenotyping (RBRCLA, v1)
- Mesenteric Lymph Node Immunophenotyping (MGP, v1)
- Spleen Immunophenotyping (MGP, v1)
- Whole blood peripheral blood leukocyte immunophenotyping (SLM, v1)
- Whole blood peripheral blood leukocyte immunophenotyping (MGP, v1)
MP browserMP:0008079
Phenotype associations stats
3.80% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased CD8-positive, alpha-beta T cell number (59/1554)
2.49% females (37/1485) 2.30% males (35/1520)
Select a parameter
Gene variants with decreased CD8-positive, alpha-beta T cell number
Total number of significant genotype-phenotype associations: 109
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Procedure | Parameter | Phenotyping Center | Source | P Value | Data |
---|---|---|---|---|---|---|---|---|
Arhgap30 Arhgap30^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage | WTSI | 3i | 0.0 | ||
Arhgef1 Arhgef1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Bach2 Bach2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Bhlhe40 Bhlhe40^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 0.0 | ||
Brd2 Brd2^{em1(IMPC)Wtsi} |
HET | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Clpp Clpp^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Effector CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Cog6 Cog6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Cog6 Cog6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Cxcr2 Cxcr2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Dlg4 Dlg4^{tm1e(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 0.0 | ||
Dph6 Dph6^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Dph6 Dph6^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Duoxa2 Duoxa2^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Gmds Gmds^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased KLRG1+ CD8 alpha beta T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Gmds Gmds^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Gmds Gmds^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Hbs1l Hbs1l^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Irgm1 Irgm1^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 0.0 | ||
Ncf2 Ncf2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 0.0 | ||
Rwdd1 Rwdd1^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells | WTSI | 3i | 0.0 | ||
Tmem127 Tmem127^{tm1(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Traf2 Traf2^{tm1a(EUCOMM)Wtsi} |
HET | postnatal | decreased CD8-positive, alpha-beta T cell number | Spleen Immunophenotyping | Total CD8+ T cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Zc3h14 Zc3h14^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage | WTSI | 3i | 0.0 | ||
Spns2 Spns2^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 1.15E-25 | ||
Tmem189 Tmem189^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 3.46E-13 | ||
Elk4 Elk4^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | HMGU | EuroPhenome | 6.01E-13 | ||
Sgms1 Sgms1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 2.32E-10 | ||
Acp2 Acp2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | MRC Harwell | EuroPhenome | 4.26E-9 | ||
Spns2 Spns2^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 9.28E-9 | ||
Usp12 Usp12^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | HMGU | MGP | 2.3E-8 | ||
Kdm7a Kdm7a^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 1.5E-7 | ||
Mcf2l Mcf2l^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 7.89E-7 | ||
Cpgi5563 Cpgi5563^{tm1.1(NCC)WCS} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 9.0E-7 | ||
Etv3 Etv3^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 9.0E-7 | ||
Tapbpl Tapbpl^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 9.0E-7 | ||
Nbeal1 Nbeal1^{tm2b(EUCOMM)Hmgu} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage | WTSI | 3i | 1.0E-6 | ||
Psg26 Psg26^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 1.0E-6 | ||
Bhlhe40 Bhlhe40^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number | WTSI | 3i | 1.4E-6 | ||
Arhgap22 Arhgap22^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 1.7E-6 | ||
Fbxo7 Fbxo7^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 2.09E-6 | ||
Smc3 Smc3^{tm1a(EUCOMM)Wtsi} |
HET | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 3.95E-6 | ||
Abhd16a Abhd16a^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 4.1E-6 | ||
Irgm1 Irgm1^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 4.1E-6 | ||
Tram2 Tram2^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 5.85E-6 | ||
Prss50 Prss50^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | MRC Harwell | EuroPhenome | 6.54E-6 | ||
Efcab3 Efcab3^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 7.3E-6 | ||
Fam234b Fam234b^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | HMGU | EuroPhenome | 1.82E-5 | ||
Cnot4 Cnot4^{tm1b(EUCOMM)Wtsi} |
HET | postnatal | decreased KLRG1+ CD8 alpha beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number | WTSI | 3i | 2.09E-5 | ||
Hmgb1 Hmgb1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 2.12E-5 | ||
Arpc1b Arpc1b^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage | WTSI | 3i | 2.26E-5 | ||
Zfp84 Zfp84^{tm1b(KOMP)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage | WTSI | 3i | 2.26E-5 | ||
Rreb1 Rreb1^{tm1b(EUCOMM)Wtsi} |
HET | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage | WTSI | 3i | 2.75E-5 | ||
Aldh2 Aldh2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | MRC Harwell | EuroPhenome | 2.85E-5 | ||
Ciao2a Ciao2a^{tm2a(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 3.1E-5 | ||
Brd2 Brd2^{em1(IMPC)Wtsi} |
HET | postnatal | decreased KLRG1+ CD8 alpha beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number | WTSI | 3i | 3.5E-5 | ||
Osbpl3 Osbpl3^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased KLRG1+ CD8 alpha beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number | WTSI | 3i | 3.5E-5 | ||
Zfp748 Zfp748^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 3.63E-5 | ||
Cbx6 Cbx6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 3.85E-5 | ||
Serf1 Serf1^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | MRC Harwell | EuroPhenome | 4.87E-5 | ||
Dlg4 Dlg4^{tm1e(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 6.04E-5 | ||
Tapbpl Tapbpl^{em1(IMPC)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number | WTSI | 3i | 6.04E-5 | ||
Esco1 Esco1^{tm1(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 6.52E-5 | ||
Gper1 Gper1^{tm1Dgen} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | FACs Analysis | T cell CD8+ percentage | HMGU | EuroPhenome | 7.78E-5 | ||
Il27 Il27^{tm1b(EUCOMM)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage | WTSI | 3i | 7.89E-5 | ||
Sec1 Sec1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 8.21E-5 | ||
Slc25a21 Slc25a21^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 8.29E-5 | ||
Dbn1 Dbn1^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 8.78E-5 | ||
Dnmt3a Dnmt3a^{tm1a(KOMP)Wtsi} |
HOM | postnatal | decreased effector memory CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage | WTSI | 3i | 8.9E-5 | ||
Ezh2 Ezh2^{tm1a(EUCOMM)Wtsi} |
HET | postnatal | decreased CD8-positive, alpha-beta T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage | WTSI | 3i | 9.72E-5 |