Phenotype: decreased CD8-positive, alpha-beta T cell number

Definition reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions

Synonyms
  • reduced CD8+ T cell number
  • reduced CD8+ T cell number
  • decreased CD8+ T cell number
  • decreased CD8+ T cell number
  • reduced CD8-positive T cell number
  • decreased CD8-positive T cell number
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Related
Synonyms
  • Absence of CD8-positive T cells
  • Absence of CD8-positive T cells
  • absent CD8-positive, alpha-beta T cells
  • absent CD8-positive, alpha-beta T cells
  • decreased CD8-positive, CD25-positive alpha-beta T cell number
  • decreased CD8-positive, alpha-beta memory T cell number
  • decreased CD8-positive, naive alpha-beta T cell number
  • decreased KLRG1+ CD8 alpha beta T cell number
  • decreased Tc17 cell number
  • decreased central memory CD8 positive, alpha-beta T cell number
  • decreased effector memory CD8-positive, alpha-beta T cell number
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MP browserMP:0008079

Phenotype associations stats

3.80% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased CD8-positive, alpha-beta T cell number (59/1554)

2.49% females (37/1485) 2.30% males (35/1520)

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Gene variants with decreased CD8-positive, alpha-beta T cell number

Total number of significant genotype-phenotype associations: 109

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Arhgap30
Arhgap30tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage WTSI | 3i 0.0
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 0.0
Brd2
Brd2em1(IMPC)Wtsi
HET Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Effector CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal decreased KLRG1+ CD8 alpha beta T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Irgm1
Irgm1em1(IMPC)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 0.0
Ncf2
Ncf2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 0.0
Rwdd1
Rwdd1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of ab T cells WTSI | 3i 0.0
Tmem127
Tmem127tm1(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Mesenteric Lymph Node Immunophenotyping | Resting CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Traf2
Traf2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased CD8-positive, alpha-beta T cell number Spleen Immunophenotyping | Total CD8+ T cells - % of CD45+ WTSI | 3i 0.0
Zc3h14
Zc3h14tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage WTSI | 3i 0.0
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.15E-25
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 3.46E-13
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 6.01E-13
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 2.32E-10
Acp2
Acp2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 4.26E-9
Spns2
Spns2tm1a(KOMP)Wtsi
HOM Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 9.28E-9
Usp12
Usp12tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | MGP 2.3E-8
Kdm7a
Kdm7atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.5E-7
Mcf2l
Mcf2ltm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 7.89E-7
Cpgi5563
Cpgi5563tm1.1(NCC)WCS
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 9.0E-7
Etv3
Etv3em1(IMPC)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 9.0E-7
Tapbpl
Tapbplem1(IMPC)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 9.0E-7
Nbeal1
Nbeal1tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage WTSI | 3i 1.0E-6
Psg26
Psg26em1(IMPC)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 1.0E-6
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell number WTSI | 3i 1.4E-6
Arhgap22
Arhgap22tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.7E-6
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 2.09E-6
Smc3
Smc3tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 3.95E-6
Abhd16a
Abhd16atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 4.1E-6
Irgm1
Irgm1em1(IMPC)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 4.1E-6
Tram2
Tram2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 5.85E-6
Prss50
Prss50tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 6.54E-6
Efcab3
Efcab3em1(IMPC)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 7.3E-6
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 1.82E-5
Cnot4
Cnot4tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased KLRG1+ CD8 alpha beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number WTSI | 3i 2.09E-5
Hmgb1
Hmgb1tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 2.12E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage WTSI | 3i 2.26E-5
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ alpha beta T cell percentage WTSI | 3i 2.26E-5
Rreb1
Rreb1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 2.75E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 2.85E-5
Ciao2a
Ciao2atm2a(EUCOMM)Wtsi
HOM Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 3.1E-5
Brd2
Brd2em1(IMPC)Wtsi
HET Female Male postnatal decreased KLRG1+ CD8 alpha beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number WTSI | 3i 3.5E-5
Osbpl3
Osbpl3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased KLRG1+ CD8 alpha beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ KLRG1+ alpha beta T cell number WTSI | 3i 3.5E-5
Zfp748
Zfp748em1(IMPC)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 3.63E-5
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 3.85E-5
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 4.87E-5
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 6.04E-5
Tapbpl
Tapbplem1(IMPC)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell number WTSI | 3i 6.04E-5
Esco1
Esco1tm1(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 6.52E-5
Gper1
Gper1tm1Dgen
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 7.78E-5
Il27
Il27tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD8+ CD44+ CD62L- alpha beta effector T cell percentage WTSI | 3i 7.89E-5
Sec1
Sec1tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 8.21E-5
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 8.29E-5
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 8.78E-5
Dnmt3a
Dnmt3atm1a(KOMP)Wtsi
HOM Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 8.9E-5
Ezh2
Ezh2tm1a(EUCOMM)Wtsi
HET Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 9.72E-5

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Images

  • Spns2tm1b(KOMP)Wtsi
    decreased CD8-positive T cell number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    decreased CD8-positive T cell number, HOM, Female, WTSI