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Phenotype: increased CD4-positive, alpha-beta T cell number

Definition
greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Synonyms
increased CD4-positive T cell number,  increased CD4+ T cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased CD4-positive, alpha-beta T cell number

Total number of significant genotype-phenotype associations: 68

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1+ CD4 alpha-beta T cell number CD4+ KLRG1+ alpha beta T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1+ CD4 alpha-beta T cell number CD4+ KLRG1+ alpha beta T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Brd2
Brd2em1(IMPC)Wtsi 		HET   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1+ CD4 alpha-beta T cell number CD4+ KLRG1+ alpha beta T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1+ CD4 alpha-beta T cell number CD4+ KLRG1+ alpha beta T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Il27
Il27tm1b(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Rwdd1
Rwdd1tm1b(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta T cell number CD4+ alpha beta T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 HMGU
EuroPhenome		 6.64×10-14
Btk
Btktm1a(EUCOMM)Hmgu 		HEM Early adult increased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 ICS
EuroPhenome		 5.04×10-09
Fam83h
Fam83hem1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.22×10-08
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.23×10-08
Clock
Clockem1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.23×10-08
Cd28
Cd28tm1a(EUCOMM)Hmgu 		HOM Early adult increased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 5.46×10-07
Setdb1
Setdb1tm1a(EUCOMM)Wtsi 		HET Early adult increased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 HMGU
EuroPhenome		 6.09×10-07
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 1.34×10-06
Mmp20
Mmp20em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.39×10-06
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.20×10-06
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult increased CD4-positive, alpha-beta T cell number CD4 T cells
Immunophenotyping		 KMPC
IMPC		 7.71×10-06
Spred1
Spred1em1(IMPC)Ccpcz 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.48×10-06
Pstpip1
Pstpip1em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.18×10-05
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.87×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

3.02% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased CD4-positive, alpha-beta T cell number (31/1028)

3.31% females (18/544) 2.24% males (13/581)

Select a parameter    



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