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Phenotype: increased NK cell number

Definition
greater number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
Synonyms
increased natural killer cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased NK cell number

Total number of significant genotype-phenotype associations: 55

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Adap1
Adap1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker NK cell number Effector NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased NK cell number Total NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Fbxw26
Fbxw26tm1b(KOMP)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Fbxw26
Fbxw26tm1b(KOMP)Wtsi 		HOM   Early adult increased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Galnt18
Galnt18tm1b(KOMP)Wtsi 		HOM   Early adult increased NK cell number Total NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Ncf2
Ncf2tm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased memory-marker NK cell number Effector NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased NK cell number Total NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult increased memory-marker NK cell number Resting NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Xpnpep1
Xpnpep1tm1a(KOMP)Wtsi 		HOM Early adult increased NK cell number NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult increased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 KMPC
IMPC		 8.51×10-26
Rras2
Rras2em1(IMPC)Ccpcz 		HOM Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.41×10-10
Emsy
Emsyem1(IMPC)Ccpcz 		HET Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.88×10-07
Jmjd6
Jmjd6tm1a(EUCOMM)Wtsi 		HET Early adult increased NK cell number NK cell percentage
FACs Analysis		 HMGU
EuroPhenome		 1.42×10-06
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.56×10-06
Tmprss6
Tmprss6tm1b(EUCOMM)Wtsi 		HOM Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 ICS
IMPC		 2.61×10-06
Uhrf1
Uhrf1tm1a(EUCOMM)Wtsi 		HET Early adult increased NK cell number NK cell percentage
FACs Analysis		 HMGU
EuroPhenome		 5.54×10-06
Cluh
Cluhem1(IMPC)Ccpcz 		HET Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 CCP-IMG
IMPC		 1.14×10-05
Tnfrsf1a
Tnfrsf1aem1(IMPC)Ccpcz 		HOM   Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.47×10-05
Setx
Setxtm1b(EUCOMM)Wtsi 		HOM   Early adult increased NK cell number NK Cells (panel B)
Immunophenotyping		 ICS
IMPC		 2.36×10-05
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 KMPC
IMPC		 2.36×10-05
Asb2
Asb2tm2b(KOMP)Wtsi 		HET   Early adult increased NK cell number NK Cells (panel B)
Immunophenotyping		 KMPC
IMPC		 3.37×10-05
Nfkbid
Nfkbidtm1a(EUCOMM)Wtsi 		HET Early adult increased NK cell number NK cell percentage
FACs Analysis		 HMGU
EuroPhenome		 3.89×10-05
Bahd1
Bahd1tm2b(KOMP)Wtsi 		HET   Early adult increased NK cell number NK Cells (panel B)
Immunophenotyping		 ICS
IMPC		 4.53×10-05
Spink6
Spink6em1(IMPC)Ccpcz 		HOM Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 CCP-IMG
IMPC		 6.34×10-05
Crx
Crxem1(IMPC)Ccpcz 		HOM Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.75×10-05
Hdac4
Hdac4em1(IMPC)Ccpcz 		HET Early adult increased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 8.09×10-05
Secisbp2
Secisbp2tm1a(EUCOMM)Wtsi 		HET Early adult increased NK cell number NK cell percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 9.29×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

3.21% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased NK cell number (33/1029)

2.43% females (13/535) 2.26% males (13/574)

Select a parameter    



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