Phenotype: increased mean corpuscular hemoglobin concentration

Definition greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices

Synonyms
  • high mean corpuscular hemoglobin concentration
  • high mean corpuscular hemoglobin concentration
  • increased MCHC
  • increased MCHC
  • increased mean corpuscular haemoglobin concentration
  • high MCHC
  • high mean corpuscular haemoglobin concentration
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Phenotype associations stats

1.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean corpuscular hemoglobin concentration (34/3416)

0.88% females (30/3394) 0.85% males (29/3404)

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Gene variants with increased mean corpuscular hemoglobin concentration

Total number of significant genotype-phenotype associations: 61

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | EuroPhenome 0.0
Prdm2
Prdm2em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 6.88E-40
Skida1
Skida1tm1(KOMP)Wtsi
HET Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration WTSI | IMPC 1.68E-10
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 3.61E-10
Bbc3
Bbc3em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 4.58E-9
Tmem94
Tmem94tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | EuroPhenome 3.68E-8
Zfp536
Zfp536tm1.1(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 5.87E-8
Cops4
Cops4tm1a(EUCOMM)Hmgu
HET Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | EuroPhenome 6.55E-7
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 7.77E-7
Atp8a1
Atp8a1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 9.74E-7
Diaph3
Diaph3tm1b(KOMP)Mbp
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 1.59E-6
Usp31
Usp31em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 2.48E-6
Fbxw2
Fbxw2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 4.12E-6
Rad18
Rad18tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | MGP 1.06E-5
Apoe
Apoetm1Unc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | EuroPhenome 1.07E-5
Sox13
Sox13tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | EuroPhenome 1.64E-5
Rab36
Rab36tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 1.79E-5
Usp45
Usp45em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 1.88E-5
Dnajc10
Dnajc10tm1a(EUCOMM)Hmgu
HOM Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 1.96E-5
Fndc4
Fndc4tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 2.66E-5
Tfr2
Tfr2em1(IMPC)Rbrc
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration RBRC | IMPC 2.68E-5
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration WTSI | IMPC 2.84E-5
Hint1
Hint1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 2.98E-5
Crlf3
Crlf3tm1a(KOMP)Wtsi
HOM Female postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | MGP 3.15E-5
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 3.64E-5
Sirt6
Sirt6tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 3.79E-5
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | EuroPhenome 3.86E-5
Snap23
Snap23tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MRC Harwell | IMPC 4.08E-5
Ahrr
Ahrrtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 4.6E-5
Rprd1b
Rprd1btm1a(EUCOMM)Hmgu
HET Female postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 6.06E-5
Fpr3
Fpr3tm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration ICS | IMPC 6.46E-5
Ifitm1
Ifitm1not yet assigned
HOM Female postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 7.07E-5
Emp3
Emp3
HOM Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 8.76E-5
Fgf9
Fgf9tm1b(KOMP)Wtsi
HET Male postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MRC Harwell | IMPC 9.8E-5
Hdac1
Hdac1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 9.81E-5

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