Phenotype: increased circulating sodium level

Definition greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume

Synonyms hypernatremia
Related
Synonyms
increased erythrocyte sodium level

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Phenotype associations stats

2.95% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating sodium level (75/2545)

2.76% females (70/2535) 2.78% males (70/2515)

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Gene variants with increased circulating sodium level

Total number of significant genotype-phenotype associations: 146

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 1.99E-17
Myo7b
Myo7btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.0E-11
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 1.8E-10
Kif1b
Kif1btm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.96E-10
Slc6a3
Slc6a3tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.5E-10
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 8.32E-10
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | MGP 1.38E-9
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium MRC Harwell | IMPC 1.76E-9
Slc8a3
Slc8a3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.42E-9
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.4E-9
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.4E-9
Pnmt
Pnmttm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.23E-8
Ajap1
Ajap1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.52E-8
Chn1
Chn1em1J
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.27E-8
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 4.87E-8
Rab40c
Rab40ctm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 5.41E-8
Gar1
Gar1tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | EuroPhenome 5.92E-8
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 1.01E-7
C9
C9tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.28E-7
Pcsk4
Pcsk4tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.43E-7
Chek2
Chek2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.49E-7
Hsf2
Hsf2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.53E-7
Coq6
Coq6tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.82E-7
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium MRC Harwell | IMPC 6.23E-7
Tmem151b
Tmem151btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.5E-7
Pla2g4f
Pla2g4ftm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | EuroPhenome 1.01E-6
Gpr68
Gpr68em2Bay
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium BCM | IMPC 1.07E-6
Cd84
Cd84tm1b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.57E-6
Sesn3
Sesn3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 1.8E-6
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.93E-6
Nacad
Nacadtm1(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 2.56E-6
Atrip
Atriptm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.63E-6
Fdxacb1
Fdxacb1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.88E-6
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 3.73E-6
BC017643
BC017643tm1a(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 3.97E-6
BC017643
BC017643tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 3.97E-6
C3
C3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.35E-6
Dnaaf2
Dnaaf2tm1.1(KOMP)Vlcg
HET Female postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 5.12E-6
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 6.43E-6
Gmfg
Gmfgtm1a(EUCOMM)Hmgu
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | EuroPhenome 8.59E-6
Ncald
Ncaldtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 8.61E-6
Cers5
Cers5tm2b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 9.06E-6
Cyb5d1
Cyb5d1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.04E-5
Brms1
Brms1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.07E-5
Fam186b
Fam186btm1b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.1E-5
Nr1i2
Nr1i2
HOM Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | EuroPhenome 1.14E-5
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium MRC Harwell | IMPC 1.17E-5
Htr1f
Htr1ftm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.38E-5
Adck2
Adck2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.39E-5
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.64E-5
Ulk3
Ulk3em2Tcp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 1.67E-5
Sdha
Sdhatm2b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.73E-5
Sptssa
Sptssatm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.84E-5
H1fx
H1fxtm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.89E-5
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 1.95E-5
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 2.07E-5
Espnl
Espnltm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.25E-5
Bach1
Bach1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.26E-5
Htr7
Htr7tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.28E-5
Ing4
Ing4em2Tcp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 2.61E-5
Ydjc
Ydjctm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.88E-5
Cacna2d3
Cacna2d3tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.25E-5
Cacna2d3
Cacna2d3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.25E-5
Rab5a
Rab5atm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.37E-5
Itga8
Itga8tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.63E-5
Anxa6
Anxa6tm1(NCOM)Cmhd
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium CMHD | EuroPhenome 4.57E-5
Nom1
Nom1tm1a(KOMP)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 4.75E-5
Myo7a
Myo7atm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 4.8E-5
Slc25a20
Slc25a20tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 5.42E-5
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 5.58E-5
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 5.87E-5
Elof1
Elof1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 6.27E-5
Ccdc57
Ccdc57tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 7.12E-5
Cfap36
Cfap36tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 7.76E-5
Nubp2
Nubp2tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 8.0E-5
Dusp4
Dusp4tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 8.02E-5
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 9.24E-5
Ceacam16
Ceacam16tm1.1(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 9.32E-5

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