Phenotype: increased circulating sodium level

Definition greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume

Synonyms
  • hypernatremia
  • hypernatremia
  • hypernatraemia
  • hypernatraemia
Related
Synonyms
increased erythrocyte sodium level

MP browserMP:0005633

Phenotype associations stats

2.50% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating sodium level (75/3003)

2.29% females (68/2969) 2.32% males (69/2968)

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Gene variants with increased circulating sodium level

Total number of significant genotype-phenotype associations: 139

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 6.74E-23
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 2.99E-17
Myo7b
Myo7btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.72E-11
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 1.59E-10
Kif1b
Kif1btm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.69E-10
Slc6a3
Slc6a3tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.2E-10
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 3.74E-9
Slc8a3
Slc8a3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.2E-9
Pnmt
Pnmttm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 6.99E-9
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.13E-9
Ajap1
Ajap1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.37E-8
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 2.05E-8
Rab40c
Rab40ctm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 5.66E-8
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 5.84E-8
Gar1
Gar1tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | MGP 5.92E-8
Hsf2
Hsf2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.81E-8
C9
C9tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.27E-7
Pcsk4
Pcsk4tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.34E-7
Chek2
Chek2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.41E-7
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 3.99E-7
Coq6
Coq6tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.59E-7
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 7.35E-7
Tmem151b
Tmem151btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 8.44E-7
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 9.29E-7
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.06E-6
Ncald
Ncaldtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.34E-6
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 1.43E-6
Cd84
Cd84tm1b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.51E-6
Atrip
Atriptm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.19E-6
Sesn3
Sesn3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 2.43E-6
Fdxacb1
Fdxacb1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.75E-6
Nacad
Nacadtm1(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 3.54E-6
Chn1
Chn1em1(IMPC)J
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.83E-6
C3
C3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.15E-6
Cers5
Cers5tm2b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.4E-6
Dnaaf2
Dnaaf2tm1.1(KOMP)Vlcg
HET Female postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 4.67E-6
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 6.14E-6
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 7.3E-6
Baz2a
Baz2aem1(IMPC)Tcp
HOM Male postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 9.72E-6
Cyb5d1
Cyb5d1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 9.99E-6
Nr1i2
Nr1i2
HOM Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | EuroPhenome 1.14E-5
Brms1
Brms1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.2E-5
Car4
Car4tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 1.23E-5
Adck2
Adck2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.38E-5
Htr1f
Htr1ftm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.39E-5
Fam186b
Fam186btm1b(KOMP)Mbp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.52E-5
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.59E-5
Sdha
Sdhatm2b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.69E-5
Sptssa
Sptssatm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 1.78E-5
Ing4
Ing4em2(IMPC)Tcp
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 1.79E-5
Dusp4
Dusp4tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 1.9E-5
Espnl
Espnltm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.14E-5
Htr7
Htr7tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.2E-5
H1fx
H1fxtm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.29E-5
BC017643
BC017643tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 2.55E-5
Ydjc
Ydjctm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.78E-5
Bach1
Bach1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 2.93E-5
Cacna2d3
Cacna2d3tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.13E-5
Rab5a
Rab5atm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.23E-5
Slc25a20
Slc25a20tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 3.32E-5
Chn1
Chn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.35E-5
Itga8
Itga8tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 3.42E-5
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium HMGU | IMPC 3.59E-5
Zfp341
Zfp341tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 4.14E-5
Anxa6
Anxa6tm1(NCOM)Cmhd
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium CMHD | EuroPhenome 4.57E-5
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Female postnatal increased circulating sodium level Clinical Chemistry | Sodium TCP | IMPC 4.68E-5
Nom1
Nom1tm1a(KOMP)Wtsi
HET Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 4.97E-5
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 5.58E-5
Myo7a
Myo7atm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 5.95E-5
Elof1
Elof1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 6.09E-5
Pla2g4f
Pla2g4ftm1a(EUCOMM)Hmgu
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | MGP 7.15E-5
Gmfg
Gmfgtm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium ICS | MGP 7.46E-5
Ceacam16
Ceacam16tm1.1(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium JAX | IMPC 7.71E-5
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | IMPC 7.98E-5
Cfap36
Cfap36tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 8.95E-5
Gsk3a
Gsk3atm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating sodium level Clinical Chemistry | Sodium WTSI | EuroPhenome 9.14E-5

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