Definition
less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction
Synonyms
decreased circulating ASAT level,
decreased circulating AAT level,
decreased circulating serum glutamic oxaloacetic transaminase level,
decreased circulating SGOT level,
reduced circulating aspartate aminotransferase level,
reduced circulating SGOT level,
decreased circulating aspartate aminotransferase level,
reduced circulating aspartate transaminase level,
reduced circulating serum glutamic oxaloacetic transaminase level,
reduced circulating AAT level,
reduced circulating ASAT level
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased circulating aspartate transaminase level
Total number of significant genotype-phenotype associations: 25
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Phactr1 Phactr1em1(IMPC)Mbp |
HOM | Late adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
UC Davis IMPC |
1.36×10-24 | |
| Fbrs Fbrsem1(IMPC)J |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
1.86×10-19 | |
| Fbxo42 Fbxo42em1(IMPC)J |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
2.20×10-12 | |
| Secisbp2l Secisbp2lem1(IMPC)J |
HOM | Late adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
3.68×10-12 | |
| Zfp532 Zfp532em1(IMPC)J |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
6.79×10-11 | |
| Gmeb2 Gmeb2em1(IMPC)J |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
3.03×10-09 | |
| Ftsj1 Ftsj1tm1b(EUCOMM)Wtsi |
HEM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
BCM IMPC |
1.75×10-08 | |
| Cog2 Cog2tm1a(KOMP)Wtsi |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
WTSI MGP |
1.04×10-07 | |
| Cyp2ab1 Cyp2ab1tm1b(KOMP)Wtsi |
HOM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
BCM IMPC |
1.65×10-06 | |
| Cdkl2 Cdkl2tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
BCM IMPC |
2.06×10-06 | |
| Or1e1c Or1e1cem1(IMPC)Mbp |
HOM | Late adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
UC Davis IMPC |
7.58×10-06 | |
| Emg1 Emg1tm1.1(KOMP)Wtsi |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
BCM IMPC |
1.46×10-05 | |
| Sar1b Sar1btm1a(EUCOMM)Wtsi |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
WTSI MGP |
1.78×10-05 | |
| Npcd Npcdem1(IMPC)J |
HOM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
2.72×10-05 | |
| Arl14 Arl14em1(IMPC)J |
HOM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
3.96×10-05 | |
| Pfas Pfasem1(IMPC)J |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
5.00×10-05 | |
| Psat1 Psat1tm1a(KOMP)Wtsi |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
WTSI MGP |
5.30×10-05 | |
| Cldn23 Cldn23em1(IMPC)J |
HOM | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
JAX IMPC |
6.06×10-05 | |
| Hsd17b4 Hsd17b4em1(IMPC)Tcp |
HET | Late adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
TCP IMPC |
6.54×10-05 | |
| Fbxl5 Fbxl5em1(IMPC)Marc |
HET | Early adult | decreased circulating aspartate transaminase level | Aspartate aminotransferase Clinical Chemistry |
MARC IMPC |
8.98×10-05 |