MP:0005586 (decreased tidal volume) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: decreased tidal volume

Definition

less than the normal volume of air inspired or expired during each normal respiratory cycle

Synonyms

reduced tidal volume

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 6

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Dll1 Dll1^tm1Gos	HET	Early adult	decreased tidal volume	TV-active Spontaneous breathing (GMC)	HMGU EuroPhenome	9.08×10^-09
Pnck Pnck^{tm1b(KOMP)Wtsi}	HEM	Early adult	decreased tidal volume	PBS Tidal volume Challenge Whole Body Plethysmography	TCP IMPC	2.69×10^-07
Unc119b Unc119b^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased tidal volume	50 Mch Tidal volume Challenge Whole Body Plethysmography	TCP IMPC	8.36×10^-07
Pnck Pnck^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased tidal volume	PBS Tidal volume Challenge Whole Body Plethysmography	TCP IMPC	4.79×10^-06
Cdh26 Cdh26^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased tidal volume	25 Mch Tidal volume Challenge Whole Body Plethysmography	TCP IMPC	6.53×10^-05

Download data as: TSV XLS

Procedure
Challenge Whole Body Plethysmography
Spontaneous breathing (GMC)

5.13% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased tidal volume (4/78)

5.06% females (4/79) 2.47% males (2/81)

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