MP:0005571 (decreased lactate dehydrogenase level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: decreased lactate dehydrogenase level

Definition

reduced level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate

Synonyms

reduced lactate dehydrogenase level, reduced LDH level, decreased LDH level

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 5

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Amfr Amfr^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased lactate dehydrogenase level	Lactate dehydrogenase Clinical Chemistry	WTSI MGP	1.31×10^-06
Epc2 Epc2^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased lactate dehydrogenase level	Lactate dehydrogenase Clinical Chemistry	HMGU EuroPhenome	3.01×10^-06
Cdipt Cdipt^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased circulating lactate dehydrogenase level	Lactate dehydrogenase Clinical Chemistry	BCM IMPC	4.55×10^-06
Kdm4c Kdm4c^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased lactate dehydrogenase level	Lactate dehydrogenase Clinical Chemistry	WTSI EuroPhenome	5.51×10^-06
Xylb Xylb^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	decreased lactate dehydrogenase level	Lactate dehydrogenase Clinical Chemistry	MRC Harwell EuroPhenome	1.88×10^-05

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0.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased lactate dehydrogenase level (5/898)

0.12% females (1/862) 0.35% males (3/863)

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