Phenotype: increased circulating total protein level

Definition total serum protein level above the normal range

Synonyms
  • hyperproteinemia
  • hyperproteinemia
  • increased plasma total protein level
  • increased plasma total protein level
  • increased total protein level
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Related
Synonyms
  • increased circulating interleukin-1 alpha level
  • increased circulating interleukin-1 alpha level
  • increased circulating renin level
  • increased circulating renin level
  • Elevated alkaline phosphatase of bone origin
  • increased circulating interferon-beta level
  • increased circulating interleukin-21 level
  • increased circulating insulin-like growth factor I level
  • increased circulating interleukin-17 level
  • increased circulating thyroid-stimulating hormone level
  • increased circulating interleukin-13 level
  • increased circulating tumor necrosis factor level
  • Hyperinsulinemia
  • Elevated alkaline phosphatase of hepatic origin
  • increased circulating interleukin-2 level
  • increased circulating interleukin-9 level
  • increased circulating interleukin-12b level
  • Fasting hyperinsulinemia
  • increased circulating interleukin-8 level
  • increased circulating atrial natriuretic factor
  • increased circulating erythropoietin level
  • increased circulating corticotropin-releasing hormone level
  • increased circulating glucagon level
  • increased circulating interleukin-3 level
  • increased circulating interleukin-7 level
  • Hyperinsulinemic hypoglycemia
  • increased circulating glutamate dehydrogenase level
  • increased circulating aspartate transaminase level
  • Fasting hyperinsulinemia
  • Hyperalbuminemia
  • increased circulating leptin level
  • Elevated alkaline phosphatase of hepatic origin
  • increased circulating interleukin-16 level
  • increased circulating parathyroid hormone level
  • Elevated alkaline phosphatase of bone origin
  • increased circulating interleukin-1 level
  • increased hemoglobin content
  • increased circulating serum albumin level
  • Elevated tissue non-specific alkaline phosphatase
  • Elevated alkaline phosphatase of renal origin
  • Elevated alkaline phosphatase of renal origin
  • increased circulating interleukin-5 level
  • increased circulating prolactin level
  • increased circulating interferon-gamma level
  • Elevated calcitonin
  • Increased circulating renin level
  • increased circulating interleukin-10 level
  • Hyperinsulinemic hypoglycemia
  • increased circulating interleukin-1 beta level
  • increased circulating interleukin-12a level
  • increased circulating insulin level
  • increased circulating interleukin-4 level
  • increased circulating alkaline phosphatase level
  • increased circulating interleukin-15 level
  • hemoglobinemia
  • increased circulating interleukin-6 level
  • Elevated circulating parathyroid hormone level
  • increased circulating interleukin-18 level
  • increased circulating gastrin level
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Phenotype associations stats

0.86% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating total protein level (33/3831)

0.79% females (30/3795) 0.63% males (24/3805)

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Gene variants with increased circulating total protein level

Total number of significant genotype-phenotype associations: 54

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 8.98E-16
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.78E-10
Hsd17b11
Hsd17b11tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein JAX | IMPC 1.7E-8
Lrba
Lrbaem1(IMPC)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 5.23E-8
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.46E-8
Cav2
Cav2em1(IMPC)KMPC
HOM Male postnatal increased circulating total protein level Clinical Chemistry | Total protein KMPC | IMPC 3.3E-7
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 6.0E-7
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein HMGU | EuroPhenome 7.34E-7
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.13E-6
Gse1
Gse1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | EuroPhenome 1.29E-6
Rab5c
Rab5ctm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 1.58E-6
Sirt4
Sirt4tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.59E-6
Pax4
Pax4tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 1.79E-6
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 2.92E-6
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein JAX | IMPC 6.4E-6
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 8.07E-6
Fam163a
Fam163atm2b(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 9.45E-6
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 1.25E-5
Kptn
Kptntm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 1.3E-5
Cacybp
Cacybptm1b(EUCOMM)Wtsi
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.86E-5
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 3.05E-5
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 3.13E-5
Casq1
Casq1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 3.14E-5
BC030499
BC030499tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein JAX | IMPC 4.05E-5
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 4.25E-5
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 4.46E-5
Cd276
Cd276tm2b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 4.74E-5
Saxo1
Saxo1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 6.43E-5
Dbil5
Dbil5tm1(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MARC | IMPC 7.37E-5
Ppbp
Ppbptm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 8.02E-5
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.22E-5
Rasd1
Rasd1tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 8.34E-5
Vgf
Vgfem1(IMPC)H
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.88E-5

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