Phenotype: increased circulating total protein level

Definition total serum protein level above the normal range

Synonyms
  • hyperproteinemia
  • hyperproteinemia
  • increased plasma total protein level
  • increased plasma total protein level
  • increased total protein level
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Related
Synonyms
  • Elevated alkaline phosphatase of hepatic origin
  • Elevated alkaline phosphatase of hepatic origin
  • Fasting hyperinsulinemia
  • Fasting hyperinsulinemia
  • increased circulating insulin level
  • Hyperinsulinemic hypoglycemia
  • Fasting hyperinsulinemia
  • increased circulating renin level
  • Hyperinsulinemic hypoglycemia
  • increased circulating thyroid-stimulating hormone level
  • increased circulating gastrin level
  • increased circulating interleukin-13 level
  • increased circulating interleukin-15 level
  • increased circulating prolactin level
  • increased circulating interleukin-8 level
  • Increased circulating renin level
  • increased circulating interleukin-18 level
  • increased circulating interferon-gamma level
  • increased circulating parathyroid hormone level
  • Elevated tissue non-specific alkaline phosphatase
  • Elevated calcitonin
  • increased circulating corticotropin-releasing hormone level
  • increased circulating aspartate transaminase level
  • increased circulating glutamate dehydrogenase level
  • Elevated circulating parathyroid hormone level
  • increased circulating interleukin-10 level
  • Elevated alkaline phosphatase of renal origin
  • increased circulating interleukin-5 level
  • increased circulating interleukin-3 level
  • increased circulating interleukin-6 level
  • Elevated alkaline phosphatase of bone origin
  • increased circulating erythropoietin level
  • Elevated alkaline phosphatase of renal origin
  • increased circulating interleukin-21 level
  • increased circulating serum albumin level
  • increased circulating interleukin-16 level
  • increased hemoglobin content
  • increased circulating interleukin-4 level
  • Hyperalbuminemia
  • increased circulating alkaline phosphatase level
  • increased circulating interleukin-12b level
  • Elevated alkaline phosphatase of bone origin
  • increased circulating interleukin-7 level
  • increased circulating interleukin-1 level
  • increased circulating interferon-beta level
  • increased circulating glucagon level
  • increased circulating interleukin-12a level
  • increased circulating interleukin-2 level
  • increased circulating interleukin-17 level
  • increased circulating insulin-like growth factor I level
  • increased circulating tumor necrosis factor level
  • Hyperinsulinemia
  • increased circulating interleukin-1 alpha level
  • hemoglobinemia
  • increased circulating interleukin-9 level
  • Elevated alkaline phosphatase of hepatic origin
  • increased circulating interleukin-1 beta level
  • increased circulating atrial natriuretic factor
  • increased circulating leptin level
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Phenotype associations stats

0.83% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating total protein level (30/3601)

0.78% females (28/3583) 0.59% males (21/3585)

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Gene variants with increased circulating total protein level

Total number of significant genotype-phenotype associations: 49

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 4.05E-17
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 1.48E-9
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 2.51E-9
Hsd17b11
Hsd17b11tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein JAX | IMPC 2.18E-8
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.41E-8
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 1.04E-7
Rab5c
Rab5ctm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 4.69E-7
Dcaf7
Dcaf7tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 5.88E-7
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein HMGU | EuroPhenome 7.34E-7
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.26E-6
Kptn
Kptntm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 1.29E-6
Gse1
Gse1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | EuroPhenome 1.29E-6
Casq1
Casq1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 1.54E-6
Sirt4
Sirt4tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.55E-6
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 2.93E-6
Pax4
Pax4tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 5.21E-6
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 1.27E-5
Fam20c
Fam20ctm1b(KOMP)Wtsi
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.32E-5
Cacybp
Cacybptm1b(EUCOMM)Wtsi
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.66E-5
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.75E-5
Derl2
Derl2tm1b(EUCOMM)Hmgu
HET Female postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 2.74E-5
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 3.03E-5
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 3.4E-5
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 3.96E-5
BC030499
BC030499tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein JAX | IMPC 5.39E-5
Dbil5
Dbil5tm1(KOMP)Wtsi
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MARC | IMPC 6.11E-5
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 7.82E-5
Cd276
Cd276tm2b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 8.01E-5
Vgf
Vgfem1(IMPC)H
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.81E-5
Esr2
Esr2em1(IMPC)Marc
HOM Female Male postnatal increased circulating total protein level Clinical Chemistry | Total protein MARC | IMPC 9.87E-5

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